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Product Info Summary
| SKU: | A02624 |
|---|---|
| Size: | 0.1 mg |
| Reactive Species: | Human, Mouse |
| Host: | Rabbit |
| Application: | ELISA, IF, ICC, WB |
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Product info
Product Name
Anti-APC2 Antibody
SKU/Catalog Number
A02624
Size
0.1 mg
Form
Liquid
Description
Boster Bio Anti-APC2 Antibody (Catalog # A02624). Tested in ELISA, WB, ICC, IF applications. This antibody reacts with Human, Mouse.
Storage & Handling
APC2 antibody can be stored at 4°C for three months and -20°C, stable for up to one year. Avoid repeated freeze-thaw cycles. Antibodies should not be exposed to prolonged high temperatures.
Cite This Product
Anti-APC2 Antibody (Boster Biological Technology, Pleasanton CA, USA, Catalog # A02624)
Host
Rabbit
Contents
APC2 Antibody is supplied in PBS containing 0.02% sodium azide.
Clonality
Polyclonal
Clone Number
Clone: SK7
Isotype
IgG
Immunogen
APC2 antibody was raised against an 18 amino acid synthetic peptide near the center of human APC2. The immunogen is located within amino acids 240 - 290 of APC2.
*Blocking peptide can be purchased. Costs vary based on immunogen length. Contact us for pricing.
Cross-reactivity
Three isoforms of KLOTHO are known to exist.
Reactive Species
A02624 is reactive to APC2 in Human, Mouse
Applications
A02624 is guaranteed for ELISA, IF, ICC, WB Boster Guarantee
Observed Molecular Weight
68 kDa
Calculated molecular weight
243.949kDa
Background of APC2
Cell cycle regulated protein ubiquitination and degradation within subcellular domains is thought to be essential for the normal progression of mitosis. APC2 is a highly conserved component of the anaphase promoting complex/cyclosome (APC/C), a cell cycle-regulated E3 ubiquitin ligase that controls progression through mitosis and the G1 phase of the cell cycle. APC/C is responsible for degrading anaphase inhibitors, mitotic cyclins, and spindle-associated proteins ensuring that events of mitosis take place in proper sequence. The individual APC/C components mRNA and protein levels are expressed at approximately the same levels in most tissues and cell lines, suggesting that they perform their functions as part of a complex. Like APC11, APC2 contains cullin and RING finger domains that are thought to be important in regulating ubiquitination activity.
Antibody Validation
Boster validates all antibodies on WB, IHC, ICC, Immunofluorescence, and ELISA with known positive control and negative samples to ensure specificity and high affinity, including thorough antibody incubations.
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Assay dilution & Images
Assay Dilutions Recommendation
The recommendations below provide a starting point for assay optimization. The actual working concentration varies and should be decided by the user.
APC2 antibody can be used for detection of APC2 by Western blot at 1 - 2 μg/mL. Antibody can also be used for immunocytochemistry starting at 5 μg/mL. For immunofluorescence start at 20 μg/mL.
Antibody validated: Western Blot in human samples; Immunocytochemistry in human samples and Immunofluorescence in human samples. All other applications and species not yet tested. Optimal dilutions for each application should be determined by the researcher.
Validation Images & Assay Conditions
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Western blot analysis of APC2 in HeLa cell lysate with APC2 antibody at (A) 1 and (B) 2 μg/mL.
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Immunocytochemistry of APC2 in HeLa cells with APC2 antibody at 5 μg/mL.
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Immunofluorescence of APC2 in HeLa cells with APC2 antibody at 20 μg/mL.
Protein Target Info & Infographic
Gene/Protein Information For APC2 (Source: Uniprot.org, NCBI)
Gene Name
APC2
Full Name
Adenomatous polyposis coli protein 2
Weight
243.949kDa
Superfamily
adenomatous polyposis coli (APC) family
Alternative Names
adenomatosis polyposis coli 2; adenomatous polyposis coli like; adenomatous polyposis coli protein 2; APCL APC2 APCL APC regulator of WNT signaling pathway 2 adenomatous polyposis coli protein 2|APC2, WNT signaling pathway regulator|adenomatosis polyposis coli 2|adenomatous polyposis coli like
*If product is indicated to react with multiple species, protein info is based on the gene entry specified above in "Species".For more info on APC2, check out the APC2 Infographic
We have 30,000+ of these available, one for each gene! Check them out.
In this infographic, you will see the following information for APC2: database IDs, superfamily, protein function, synonyms, molecular weight, chromosomal locations, tissues of expression, subcellular locations, post-translational modifications, and related diseases, research areas & pathways. If you want to see more information included, or would like to contribute to it and be acknowledged, please contact [email protected].
Specific Publications For Anti-APC2 Antibody (A02624)
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No publications found for A02624
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Customer Reviews
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