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Product Info Summary
| SKU: | A03850 |
|---|---|
| Size: | 0.1 mg |
| Reactive Species: | Human, Mouse |
| Host: | Rabbit |
| Application: | ELISA, IF, IHC-P, WB |
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Product info
Product Name
Anti-Bfl-1 BCL2A1 Antibody
View all Bcl-2 related protein A1 Antibodies
SKU/Catalog Number
A03850
Size
0.1 mg
Form
Liquid
Description
Boster Bio Anti-Bfl-1 BCL2A1 Antibody (Catalog # A03850). Tested in ELISA, WB, IHC-P, IF applications. This antibody reacts with Human, Mouse.
Storage & Handling
Bfl-1 antibody can be stored at 4°C for three months and -20°C, stable for up to one year. Avoid repeated freeze-thaw cycles. Antibodies should not be exposed to prolonged high temperatures.
Cite This Product
Anti-Bfl-1 BCL2A1 Antibody (Boster Biological Technology, Pleasanton CA, USA, Catalog # A03850)
Host
Rabbit
Contents
Bfl-1 Antibody is supplied in PBS containing 0.02% sodium azide.
Clonality
Polyclonal
Isotype
IgG
Immunogen
Bfl-1 antibody was raised against a 14 amino acid synthetic peptide from near the carboxy terminus of human Bfl-1. The immunogen is located within the last 50 amino acids of Bfl-1.
*Blocking peptide can be purchased. Costs vary based on immunogen length. Contact us for pricing.
Cross-reactivity
At least two isoforms of Bfl-1 are known to exist; this antibody will only detect the larger isoform.
Reactive Species
A03850 is reactive to BCL2A1 in Human, Mouse
Applications
A03850 is guaranteed for ELISA, IF, IHC-P, WB Boster Guarantee
Observed Molecular Weight
68 kDa
Calculated molecular weight
20.132kDa
Background of Bcl-2 related protein A1
Apoptosis plays a major role in normal organism development, tissue homeostasis, and removal of damaged cells and is caused by caspase activation. Proteins that comprise the Bcl-2 family appear to control the activation of these enzymes. One such member is multi-domain antiapoptotic protein Bfl-1, which is overexpressed in stomach and other cancers. Bfl-1 can interact with Bax and suppress apoptosis by inhibiting the release of cytochrome c and caspase-3 activation. It is upregulated in cisplatin-resistant human bladder tumors, suggesting that its expression may be important for cisplatin resistance and inhibition of apoptosis in cancer cells.
Antibody Validation
Boster validates all antibodies on WB, IHC, ICC, Immunofluorescence, and ELISA with known positive control and negative samples to ensure specificity and high affinity, including thorough antibody incubations.
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Assay dilution & Images
Assay Dilutions Recommendation
The recommendations below provide a starting point for assay optimization. The actual working concentration varies and should be decided by the user.
Bfl-1 antibody can be used for the detection of Bfl-1 by Western blot at 1 μg/mL. Antibody can also be used for immunohistochemistry starting at 10 μg/mL. For immunofluorescence start at 20 μg/mL.
Antibody validated: Western Blot in human samples; Immunohistochemistry in mouse samples and Immunofluorescence in mouse samples. All other applications and species not yet tested. Optimal dilutions for each application should be determined by the researcher.
Validation Images & Assay Conditions
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Western blot analysis of Bfl-1 in (A) human kidney and (B) human lung tissue lysate with Bfl-1 antibody at 1 μg/mL.
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Immunohistochemistry of Bfl-1 in mouse kidney tissue with Bfl-1 antibody at 10 μg/mL.
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Immunofluorescence of Bfl-1 in Mouse Kidney tissue with Bfl-1 antibody at 20 μg/mL.
Protein Target Info & Infographic
Gene/Protein Information For BCL2A1 (Source: Uniprot.org, NCBI)
Gene Name
BCL2A1
Full Name
Bcl-2-related protein A1
Weight
20.132kDa
Superfamily
Bcl-2 family
Alternative Names
ACC-1; ACC-2; Bcl-2 related protein A1; BCL2A1; Bcl2L5; Bcl2-L-5; BCL2L5HBPA1; Bcl-2-like protein 5; BCL2-related protein A1; Bfl-1; BFL1bcl-2-related protein A1; GRS; GRSbcl2-L-5; hematopoietic BCL2-related protein A1; Hemopoietic-specific early response protein; Protein BFL-1; Protein GRS BCL2A1 ACC-1, ACC-2, ACC1, ACC2, BCL2L5, BFL1, GRS, HBPA1 BCL2 related protein A1 bcl-2-related protein A1|bcl-2-like protein 5|bcl2-L-5|hematopoietic BCL2-related protein A1|hemopoietic-specific early response protein|protein BFL-1
*If product is indicated to react with multiple species, protein info is based on the gene entry specified above in "Species".For more info on BCL2A1, check out the BCL2A1 Infographic
We have 30,000+ of these available, one for each gene! Check them out.
In this infographic, you will see the following information for BCL2A1: database IDs, superfamily, protein function, synonyms, molecular weight, chromosomal locations, tissues of expression, subcellular locations, post-translational modifications, and related diseases, research areas & pathways. If you want to see more information included, or would like to contribute to it and be acknowledged, please contact [email protected].
Specific Publications For Anti-Bfl-1 BCL2A1 Antibody (A03850)
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No publications found for A03850
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Customer Reviews
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