Anti-CD45/Ptprc Antibody Picoband™

Ptprc antibody

Boster Bio Anti-CD45/Ptprc Antibody Picoband™ catalog # A00555-4. Tested in ELISA, IHC, WB applications. This antibody reacts with Mouse, Rat. Cited in 4 publication(s).

Product Info Summary

SKU: A00555-4
Size: 100 μg/vial
Reactive Species: Mouse, Rat
Host: Rabbit
Application: ELISA, IHC, WB

Product Name

Anti-CD45/Ptprc Antibody Picoband™

View all Ptprc Antibodies

SKU/Catalog Number

A00555-4

Size

100 μg/vial

Form

Lyophilized

Description

Boster Bio Anti-CD45/Ptprc Antibody Picoband™ catalog # A00555-4. Tested in ELISA, IHC, WB applications. This antibody reacts with Mouse, Rat.

Storage & Handling

At -20°C for one year from date of receipt. After reconstitution, at 4°C for one month. It can also be aliquotted and stored frozen at -20°C for six months. Avoid repeated freezing and thawing.

Cite This Product

Anti-CD45/Ptprc Antibody Picoband™ (Boster Biological Technology, Pleasanton CA, USA, Catalog # A00555-4)

Host

Rabbit

Contents

Each vial contains 4 mg Trehalose, 0.9 mg NaCl, 0.2 mg Na2HPO4.

Clonality

Polyclonal

Immunogen

E.coli-derived mouse CD45/Ptprc recombinant protein (Position: N209-E1269).

*Blocking peptide can be purchased. Costs vary based on immunogen length. Contact us for pricing.

Reactive Species

A00555-4 is reactive to Ptprc in Mouse, Rat

Applications

A00555-4 is guaranteed for ELISA, IHC, WB Boster Guarantee

Background of Ptprc

CD45(Cluster of Differentiation 45), also known as PTPRC, LCA or CD45R, is an enzyme that, in humans, is encoded by the PTPRC gene. CD45 is a member of the protein tyrosine phosphatase (PTP) family. CD45 is a major high molecular mass leukocyte cell surface molecule which is also an integral membrane protein tyrosine phosphatase. The cytogenetic location of CD45 is 1q31.3-q32.1. CD45 is especially a prototype for transmembrane protein-tyrosine phosphatase (PTP). Targeted disruption of the CD45 gene leads to enhanced cytokine and interferon receptor-mediated activation of JAKs and STAT proteins. In vitro, CD45 directly dephosphorylates and binds to JAKs. Functionally, CD45 negatively regulates interleukin-3-mediated cellular proliferation, erythropoietin-dependent hematopoiesis, and antiviral responses in vitro and in vivo. CD45 has been best studied in T cells, where it determines T cell receptor signaling thresholds. CD45 is moved into or out of the immunological synapse (IS) membrane microdomain depending on the relative influence of interaction with the extracellular galectin lattice or the intracellular actin cytoskeleton. Galectin interaction can be finetuned by varying usage of the heavily Oglycosylated spliced regions and sialylation of Nlinked carbohydrates.

Antibody Validation

Boster validates all antibodies on WB, IHC, ICC, Immunofluorescence and ELISA with known positive and negative samples to ensure specificity and high affinity.

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Reconsitution

Adding 0.2 ml of distilled water will yield a concentration of 500 μg/ml.

Assay Dilutions Recommendation

The recommendations below provide a starting point for assay optimization. Actual working concentration varies and should be decided by the user.

Western blot, 0.25-0.5 μg/ml, Mouse
Immunohistochemistry(Paraffin-embedded Section), 2-5 μg/ml, Mouse, Rat
Direct ELISA, 0.1-0.5 μg/ml, Mouse

Validation Images & Assay Conditions

Gene/Protein Information For Ptprc (Source: Uniprot.Org, NCBI)

Uniprot ID

P06800

Gene ID

19264

Gene Name

Ptprc

Full Name

Receptor-type tyrosine-protein phosphatase C

Weight

144.837kDa

Superfamily

protein-tyrosine phosphatase family

Alternative Names

B220; CD45 antigen; CD45; CD45R; EC 3.1.3.48; LCA; L-CA; LY5; protein tyrosine phosphatase, receptor type, C; PTPRC; receptor-type tyrosine-protein phosphatase C; T200 Glycoprotein; T200 leukocyte common antigen; T200receptor type, c polypeptide Ptprc|B220, CD45R, Cd45, L-CA, Ly-, Ly-5, Lyt-, Lyt-4, T200, loc|protein tyrosine phosphatase, receptor type, C|receptor-type tyrosine-protein phosphatase C|leukocyte common antigen|lymphocyte antigen 5|lymphocyte common antigen

*if product is indicated to react with multiple species, protein info is based on the gene entry specified above in "species".

For more info on Ptprc, check out the Ptprc Infographic

Ptprc infographic

We have 30,000+ of these available, one for each gene! check them out.

In this infographic you will see the following information for Ptprc: database IDs, super-family, protein function, synonyms, molecular weight, chromosomal locations, tissues of expression, subcellular locations, post translational modifications, and related diseases, research areas & pathways. If you want to see more information included, or would like to contribute to it and be acknowledged, please contact us [email protected]

A00555-4 has been cited in 4 publications:

*The publications in this section are manually curated by our staff scientists. They may differ from Bioz's machine gathered results. Both are accurate. If you find a publication citing this product but is missing from this list, please let us know we will issue you a thank-you coupon.

Zinc Prevents Abdominal Aortic Aneurysm Formation by Induction of A20-Mediated Suppression of NF-κB Pathway

Co-cultured the MSCs and cardiomyocytes can promote the growth of cardiomyocytes

Mesenchymal stem cells protect islets from hypoxia/reoxygenation‐induced injury

Inhibitory effect of mesenchymal stem cells on lymphocyte proliferation

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Conjugation

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Size

Total: $315

Size:100 μg

SKU:A00555-4

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A00555-4
Buy one primary antibody get one 0.5ml HRP or Biotin secondary antibody for free.
*Sample sizes are prepared on demand and will take extra lead time. (cannot be conjugated)
$315.00

$50 fee for conjugation. Antibody size is reduced to 50ug.

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