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- Table of Contents
PTPRC Antibodies
AND PTPRC ELISA kits, PTPRC Proteins
Many biological assays use antibodies to detect PTPRC, such as Western Blot (WB), ELISA, Flow Cytometry, Immunocytochemistry (IHC). These antibodies can be polyclonal or monoclonal, and react with PTPRC in Human, Mouse, Rat, and many other animal samples. Boster Bio use mainly mouse and rabbit to develop PTPRC antibodies...
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PTPRC Infographic by Boster Bio
All PTPRC Products
Product
Figures
Specificity
Applications
Price
Anti-CD45/PTPRC Antibody Picoband®
1 Citations 16 Q&As
Human
Flow Cytometry, IF, IHC, WB
$370
Cat # PB9785
100 μg/vial
Cat # PB9785
100 μg/vial
Anti-CD45/PTPRC Antibody Picoband®
1 Citations 5 Q&As
Human
IF, IHC, ICC, WB
$370
Cat # PA1596
100 μg/vial
Cat # PA1596
100 μg/vial
Anti-CD45/PTPRC Antibody Picoband®
1 Citations 5 Q&As
Human
Flow Cytometry, IF, IHC, WB
$370
Cat # PB9096
100 μg/vial
Cat # PB9096
100 μg/vial
Anti-CD45 PTPRC Antibody
1 Citations 15 Q&As
Human, Mouse, Rat
ELISA, IF, IHC, WB
$399
Cat # A00555
100μl
Cat # A00555
100μl
Human
Flow Cytometry, IF, IHC, ICC, WB
$370
Cat # M00555-1
100 μl
Cat # M00555-1
100 μl
Human
IHC, WB
$449
Cat # M00555-2
100uL
Cat # M00555-2
100uL
Human
Flow Cytometry, IP, IHC-P, ICC, WB
$299
Cat # M00555-3
0.1 mg
Cat # M00555-3
0.1 mg
Mouse
Flow Cytometry, IP, ICC, WB
$299
Cat # M00555-4
0.1 mg
Cat # M00555-4
0.1 mg
Anti-CD45/PTPRC Antibody Picoband®
4 Citations
Human
ELISA, Flow Cytometry, IF, IHC, WB
$370
Cat # A00555-3
100 μg/vial
Cat # A00555-3
100 μg/vial
Human
Flow Cytometry, IF, IHC, WB
$370
Cat # M00555-5
100 μg/vial
Cat # M00555-5
100 μg/vial
Human
Flow Cytometry, IF, IHC, WB
$370
Cat # M00555-6
100 μg/vial
Cat # M00555-6
100 μg/vial
Anti-CD45/Ptprc Antibody Picoband®
10 Citations
Mouse, Rat
ELISA, IF, IHC, ICC, WB
$370
Cat # A00555-4
100 μg/vial
Cat # A00555-4
100 μg/vial
Human
ELISA, Flow Cytometry, Functional Assay, Kinetics
$486
Cat # M00555-8
100 μg
Cat # M00555-8
100 μg
Human
ELISA, Flow Cytometry, Functional Assay, Kinetics
$486
Cat # M00555-9
100 μg
Cat # M00555-9
100 μg
Human
ELISA, IP, IF, IHC, WB
$146
Cat # M00555-10
20μL, 40μL, 100μL, 200μL
Cat # M00555-10
20μL, 40μL, 100μL, 200μL
PTPRC Overview
Facts about Receptor-type tyrosine-protein phosphatase C.
Receptor-type tyrosine-protein phosphatase C (PTPRC)
Protein tyrosine-protein phosphatase required for T-cell activation through the antigen receptor. Acts as a positive regulator of T-cell coactivation upon binding to DPP4.
The first PTPase domain has enzymatic activity, while the second one seems to affect the substrate specificity of the initial one. Upon T-cell activation, recruits and dephosphorylates SKAP1 and FYN.
Gene Information
| Human | |
|---|---|
| Gene Name: | PTPRC |
| Uniprot: | P08575 |
| Entrez: | 5788 |
Family
| Belongs to: |
|---|
| protein-tyrosine phosphatase family |
Alternative Names
B220; CD45 antigen; CD45; CD45R; EC 3.1.3.48; LCA; L-CA; LY5; protein tyrosine phosphatase, receptor type, C; PTPRC; receptor-type tyrosine-protein phosphatase C; T200 Glycoprotein; T200 leukocyte common antigen; T200receptor type, c polypeptide
Molecular Weight
Mass (kDA):
147.486 kDA
Genomic Context
| Human | |
|---|---|
| Location: | 1q31.3-q32.1 |
| Sequence: | 1; NC_000001.11 (198638968..198757476) |
Tissue Specificity
Isoform 1: Detected in thymocytes. Isoform 2: Detected in thymocytes. Isoform 3: Detected in thymocytes. Isoform 4: Not detected in thymocytes. Isoform 5: Detected in thymocytes. Isoform 6: Not detected in thymocytes. Isoform 7: Detected in thymocytes. Isoform 8: Not detected in thymocytes.
Subcellular Localizations
Cell membrane; Single-pass type I membrane protein. Membrane raft. Colocalized with DPP4 in membrane rafts.
Diseases
- Neoplasms
- Inflammation
- Malignant Neoplasms
- Tissue Adhesions
- Autoimmune Reaction
- Leukemia
- Fibrosis
- Carcinoma
- Pathologic Neovascularization
- Multiple Sclerosis
- Sclerosis
- Lymphoma
- Tumor Angiogenesis
Interacting Proteins
- CSK
- CTNNB1
- ERBB2
- ITGAL
- LCK
- Lck
- LGALS1
- TEK
Pathways
- Pathogenesis
- Secretion
- Angiogenesis
- Regeneration
- Localization
- Cell Adhesion
- Cell Activation
- Immune Response
- Cell Proliferation
- T Cell Activation
- Cell Differentiation
- Cell Cycle
- Cell Development
PTMs
- Phosphorylation
- Dephosphorylation
- Cleavage
- Reduction
Research Areas
- Mesenchymal Stem Cell Markers
- Stem Cell Markers
For details, visit:
bosterbio.com/bosterbio-gene-info-cards/PTPRC
bosterbio.com/bosterbio-gene-info-cards/PTPRC
References
PMID: 2824653 by Streuli M., et al. Differential usage of three exons generates at least five different mRNAs encoding human leukocyte common antigens.
PMID: 2956090 by Ralph S.J., et al. Structural variants of human T200 glycoprotein (leukocyte-common antigen).
15 Publications of Boster PTPRC Antibodies & ELISA Kits
- PubMed ID: 10.1371/journal.pone.0148536, Zinc Prevents Abdominal Aortic Aneurysm Formation by Induction of A20-Mediated S...
- PubMed ID: 10.1111/1440-1681.13059, MicroRNA let‐7c‐5p promotes osteogenic differentiation of dental pulp stem c...
- PubMed ID: 10.1039/C5AN00799B, Deformability and size-based cancer cell separation using an integrated microflu...
- PubMed ID: 10.1007/s10616-018-0188-6, Co-cultured the MSCs and cardiomyocytes can promote the growth of cardiomyocytes
- PubMed ID: 10.1002/cbf.1701, Mesenchymal stem cells protect islets from hypoxia/reoxygenation‐induced injur...
- PubMed ID: 10.1002/cbf.1523, Inhibitory effect of mesenchymal stem cells on lymphocyte proliferation
- PubMed ID: 26681001, Effect of human umbilical cord mesenchymal stem cells on endometriotic cell prol...
- PubMed ID: 20682645, Lipoxin A4 and its analogue suppress the tumor growth of transplanted H22 in mic...
- PubMed ID: 26109430, Detecting cell-in-cell structures in human tumor samples by E-cadherin/CD68/CD45...
- PubMed ID: 26526388, CD11b deficiency suppresses intestinal tumor growth by reducing myeloid cell rec...
- PubMed ID: 12133481, Fas counterattack in cholangiocarcinoma: A mechanism for immune evasion in human...
- PubMed ID: 26616638, Isolation and morphological characterization of ovine amniotic fluid mesenchymal...
- PubMed ID: 21167388, Huang Y, Jia X, Bai K, Gong X, Fan Y. Arch Med Res. 2010 Oct;41(7):497-505. Doi:...
- PubMed ID: 24681515, Liu D, Wang Y, Ye Y, Yin G, Chen L. Cell Immunol. 2014 May-Jun;289(1-2):7-14. Do...
- PubMed ID: 23630099, Li X, Huang Y, Zheng L, Liu H, Niu X, Huang J, Zhao F, Fan Y. J Biomed Mater Res...
*More publications can be found for each product on its corresponding product page