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Product Info Summary
| SKU: | A08274-1 |
|---|---|
| Size: | 0.1 mg |
| Reactive Species: | Human, Mouse, Rat |
| Host: | Rabbit |
| Application: | ELISA, IF, IHC-P, WB |
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Product info
Product Name
Anti-Cell death regulator Aven Aven Antibody
SKU/Catalog Number
A08274-1
Size
0.1 mg
Form
Liquid
Description
Boster Bio Anti-Cell death regulator Aven Aven Antibody (Catalog # A08274-1). Tested in ELISA, WB, IHC-P, IF applications. This antibody reacts with Human, Mouse, Rat.
Storage & Handling
Aven antibody can be stored at 4°C for three months and -20°C, stable for up to one year. Avoid repeated freeze-thaw cycles. Antibodies should not be exposed to prolonged high temperatures.
Cite This Product
Anti-Cell death regulator Aven Aven Antibody (Boster Biological Technology, Pleasanton CA, USA, Catalog # A08274-1)
Host
Rabbit
Contents
Aven Antibody is supplied in PBS containing 0.02% sodium azide.
Clonality
Polyclonal
Isotype
IgG
Immunogen
Aven antibody was raised against a 14 amino acid synthetic peptide from near the carboxy terminus of human Aven. The immunogen is located within the last 50 amino acids of Aven.
*Blocking peptide can be purchased. Costs vary based on immunogen length. Contact us for pricing.
Cross-reactivity
SPRYD2 antibody is predicted to not cross-react with other SPRYD protein family members. At least four isoforms of SPRYD2 are known to exist.
Reactive Species
A08274-1 is reactive to AVEN in Human, Mouse, Rat
Applications
A08274-1 is guaranteed for ELISA, IF, IHC-P, WB Boster Guarantee
Observed Molecular Weight
68 kDa
Calculated molecular weight
38.506kDa
Background of AVEN
Apoptosis plays a major role in normal organism development, tissue homeostasis, and removal of damaged cells. Disruption of this process has been implicated in a variety of diseases such as cancer. Aven is a recently discovered protein that blocks apoptosis induced by Apaf-1 and caspase-9. It is thought that Aven functions by binding to Bcl-xL, an antiapoptotic member of the Bcl-2 family, and to Apaf-1, possibly interfering with the ability of Apaf-1 to self-associate, suggesting that Aven impedes Apaf-1-mediated caspase activation. Higher levels of Aven mRNA are seen in patients with acute leukemia than in control patients, suggesting that Aven may be useful as a prognostic indicator in leukemia patients.
Antibody Validation
Boster validates all antibodies on WB, IHC, ICC, Immunofluorescence, and ELISA with known positive control and negative samples to ensure specificity and high affinity, including thorough antibody incubations.
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Assay dilution & Images
Assay Dilutions Recommendation
The recommendations below provide a starting point for assay optimization. The actual working concentration varies and should be decided by the user.
Aven antibody can be used for detection of Aven by Western blot at 1 μg/mL. Despite its predicted molecular weight, Aven often migrates at 55 kDa in SDS-PAGE. Antibody can also be used for immunohistochemistry starting at 5 μg/mL. For immunofluorescence start at 20 μg/mL.
Antibody validated: Western Blot in human samples; Immunohistochemistry in human samples and Immunofluorescence in human samples. All other applications and species not yet tested. Optimal dilutions for each application should be determined by the researcher.
Validation Images & Assay Conditions
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Western blot analysis of Aven in Raji cell lysate with Aven antibody at 1 μg/mL in (A) the presence and (B) the absence of blocking peptide.
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Immunohistochemistry of Aven in human spleen tissue with Aven antibody at 5 μg/mL.
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Immunofluorescence of AVEN in Human Spleen cells with AVEN antibody at 20 μg/mL.
Protein Target Info & Infographic
Gene/Protein Information For AVEN (Source: Uniprot.org, NCBI)
Gene Name
AVEN
Full Name
Cell death regulator Aven
Weight
38.506kDa
Alternative Names
apoptosis, caspase activation inhibitor; cell death regulator Aven; PDCD12; programmed cell death 12 AVEN PDCD12 apoptosis and caspase activation inhibitor cell death regulator Aven|apoptosis, caspase activation inhibitor|programmed cell death 12
*If product is indicated to react with multiple species, protein info is based on the gene entry specified above in "Species".For more info on AVEN, check out the AVEN Infographic
We have 30,000+ of these available, one for each gene! Check them out.
In this infographic, you will see the following information for AVEN: database IDs, superfamily, protein function, synonyms, molecular weight, chromosomal locations, tissues of expression, subcellular locations, post-translational modifications, and related diseases, research areas & pathways. If you want to see more information included, or would like to contribute to it and be acknowledged, please contact [email protected].
Specific Publications For Anti-Cell death regulator Aven Aven Antibody (A08274-1)
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No publications found for A08274-1
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