Product Info Summary
SKU: | A00559 |
---|---|
Size: | 100ul |
Reactive Species: | Human, Mouse, Rat |
Host: | Rabbit |
Application: | IHC |
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Product info
Product Name
Anti-FBN1 (N2843) Antibody
View all Fibrillin 1 Antibodies
SKU/Catalog Number
A00559
Size
100ul
Form
Liquid
Description
Boster Bio Anti-FBN1 (N2843) Antibody catalog # A00559. Tested in IHC applications. This antibody reacts with Human,Mouse,Rat.
Storage & Handling
Store at -20°C for one year. For short term storage and frequent use, store at 4°C for up to one month. Avoid repeated freeze-thaw cycles.
Cite This Product
Anti-FBN1 (N2843) Antibody (Boster Biological Technology, Pleasanton CA, USA, Catalog # A00559)
Host
Rabbit
Contents
Rabbit IgG, 1mg/ml in PBS with 0.02% sodium azide, 50% glycerol, pH7.2
Clonality
Polyclonal
Isotype
IgG
Immunogen
Synthesized peptide derived from human AIRE-1 around the phosphorylation site of S156.
*Blocking peptide can be purchased. Costs vary based on immunogen length. Contact us for pricing.
Reactive Species
A00559 is reactive to FBN1 in Human, Mouse, Rat
Applications
A00559 is guaranteed for IHC Boster Guarantee
Observed Molecular Weight
Calculated molecular weight
312.298kDa
Background of Fibrillin 1
Transcriptional regulator that binds to DNA as a dimer or as a tetramer, but not as a monomer. Binds to G-doublets in an A/T-rich environment; the preferred motif is a tandem repeat of 5'-. ATTGGTTA-3' combined with a 5'-TTATTA-3' box. Binds to nucleosomes By similarity. Binds to chromatin and interacts selectively with histone H3 that is not methylated at 'Lys-4', not phosphorylated at 'Thr-3' and not methylated at 'Arg-2'. Functions as a sensor of histone H3 modifications that are important for the epigenetic regulation of gene expression. Functions as a transcriptional activator and promotes the expression of otherwise tissue-specific self-antigens in the thymus, which is important for self tolerance and the avoidance of autoimmune reactions.
Nagamine K., Nat. Genet. 17:393-398(1997).
Aaltonen J., Nat. Genet. 17:399-403(1997).
Hattori M., Nature 405:311-319(2000).
Antibody Validation
Boster validates all antibodies on WB, IHC, ICC, Immunofluorescence, and ELISA with known positive control and negative samples to ensure specificity and high affinity, including thorough antibody incubations.
Innovating Scientists Reward
If you are the first to review this product, or if you have results for a special sample, species or application this product is not validated in, share your results with us and receive product credits you can use towards any Boster products! Applicable to all scientists worldwide.
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Assay dilution & Images
Assay Dilutions Recommendation
The recommendations below provide a starting point for assay optimization. The actual working concentration varies and should be decided by the user.
IHC: 1:50-1:200
Validation Images & Assay Conditions
Click image to see more details
Figure 1. Immunohistochemistry validation of FBN1 using Anti-FBN1 (N2843) Antibody (A00559).
Immunohistochemistry (IHC) analyzes of FBN1 (N2843) pAb in paraffin-embedded human breast carcinoma tissue at 1:100.For more protocol information of IHC
Protein Target Info & Infographic
Gene/Protein Information For FBN1 (Source: Uniprot.org, NCBI)
Gene Name
FBN1
Full Name
Fibrillin-1
Weight
312.298kDa
Superfamily
fibrillin family
Alternative Names
ACMICD; Asprosin; FBN; FBN1; fibrillin 1 (Marfan syndrome); Fibrillin 1; fibrillin 15; fibrillin-1; GPHYSD2; MASS; MFS1; OCTD; SGS; SSKS; WMS; WMS2 FBN1 ACMICD, ECTOL1, FBN, GPHYSD2, MASS, MFLS, MFS1, OCTD, SGS, SSKS, WMS, WMS2 fibrillin 1 fibrillin-1|asprosin|epididymis secretory sperm binding protein|fibrillin 15|fibrillin-1 preproprotein
*If product is indicated to react with multiple species, protein info is based on the gene entry specified above in "Species".For more info on FBN1, check out the FBN1 Infographic
We have 30,000+ of these available, one for each gene! Check them out.
In this infographic, you will see the following information for FBN1: database IDs, superfamily, protein function, synonyms, molecular weight, chromosomal locations, tissues of expression, subcellular locations, post-translational modifications, and related diseases, research areas & pathways. If you want to see more information included, or would like to contribute to it and be acknowledged, please contact [email protected].
Specific Publications For Anti-FBN1 (N2843) Antibody (A00559)
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No publications found for A00559
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