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Product Info Summary
| SKU: | A06261 |
|---|---|
| Size: | 0.1 mg |
| Reactive Species: | Human |
| Host: | Rabbit |
| Application: | ELISA, IF, IHC-P, WB |
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Product info
Product Name
Anti-Fn14 TNFRSF12A Antibody
View all TWEAK R/TNFRSF12 Antibodies
SKU/Catalog Number
A06261
Size
0.1 mg
Form
Liquid
Description
Boster Bio Anti-Fn14 TNFRSF12A Antibody (Catalog # A06261). Tested in ELISA, WB, IHC-P, IF applications. This antibody reacts with Human.
Storage & Handling
Fn14 antibody can be stored at 4°C for three months and -20°C, stable for up to one year. Avoid repeated freeze-thaw cycles. Antibodies should not be exposed to prolonged high temperatures.
Cite This Product
Anti-Fn14 TNFRSF12A Antibody (Boster Biological Technology, Pleasanton CA, USA, Catalog # A06261)
Host
Rabbit
Contents
Fn14 Antibody is supplied in PBS containing 0.02% sodium azide.
Clonality
Polyclonal
Isotype
IgG
Immunogen
Fn14 antibody was raised against a human IgG1 Fc-tagged Fn14 protein.
*Blocking peptide can be purchased. Costs vary based on immunogen length. Contact us for pricing.
Cross-reactivity
DNAJC13 antibody is human and mouse reactive. At least two siforms of DNAJC13 are known to exist; this antibody will detect both isoforms. DNAJC13 antibody is predicted to not cross-react with other DNAJC family members.
Reactive Species
A06261 is reactive to Tnfrsf12a in Human
Applications
A06261 is guaranteed for ELISA, IF, IHC-P, WB Boster Guarantee
Observed Molecular Weight
68 kDa
Calculated molecular weight
13.641kDa
Background of TWEAK R/TNFRSF12
TWEAK is a TNF family member produced by IFN-gamma-stimulated monocytes and induces multiple cell death pathways including caspase-dependent apoptosis and cathepsin B-dependent necrosis. These pathways are mediated by the binding of TWEAK by fibroblast growth factor 14 (Fn14), a member of the TNF receptor superfamily. Yeast two-hybrid experiments have shown that FN14 will bind to the TNFR-associated factors TRAF1, TRAF2, TRAF3, and TRAF5, suggesting that the signaling pathway induced by TWEAK may be mediated by one or more of these adaptor molecules. Fn14 is induced during liver regeneration and is highly expressed in hepatocellular carcinomas. In addition, TWEAK induces liver progenitor cell proliferation, suggesting Fn14 may play a role in hepatocyte growth control and liver neoplasia.
Antibody Validation
Boster validates all antibodies on WB, IHC, ICC, Immunofluorescence, and ELISA with known positive control and negative samples to ensure specificity and high affinity, including thorough antibody incubations.
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Assay dilution & Images
Assay Dilutions Recommendation
The recommendations below provide a starting point for assay optimization. The actual working concentration varies and should be decided by the user.
Predicted: 62kD
Observed: 68kD Optimal dilutions for each application should be determined by the researcher.
Validation Images & Assay Conditions
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Western blot analysis of Fn14 in HepG2 cells with Fn14 antibody at (A) 2 and (B) 4 μg/mL.
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Immunohistochemistry of Fn14 in human liver tissue with Fn14 antibody at 2.5 μg/mL.
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Immunofluorescence of Fn14 in Human Liver cells with Fn14 antibody at 20 μg/mL.
Protein Target Info & Infographic
Gene/Protein Information For Tnfrsf12a (Source: Uniprot.org, NCBI)
Gene Name
Tnfrsf12a
Full Name
Tumor necrosis factor receptor superfamily member 12A
Weight
13.641kDa
Alternative Names
CD266 antigen; CD266; FGF-inducible 14; Fibroblast growth factor-inducible immediate-early response protein 14; Fn14; FN14tumor necrosis factor receptor superfamily member 12A; TNFRSF12; TNFRSF12A; tumor necrosis factor receptor superfamily, member 12A; TWEAK R; TWEAKR; tweak-receptor; type I transmembrane protein Fn14 Tnfrsf12a|AI255180, C87282, Fn1, Fn14, HPIP, TWEAK, TWEAK-R, Twea, TweakR|tumor necrosis factor receptor superfamily, member 12a|tumor necrosis factor receptor superfamily member 12A|FGF-inducible 14|fibroblast growth factor-inducible immediate-early response protein 14|fibroblast growth factor-regulated protein 2|tweak-receptor|type I transmembrane protein Fn14
*If product is indicated to react with multiple species, protein info is based on the gene entry specified above in "Species".For more info on Tnfrsf12a, check out the Tnfrsf12a Infographic
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In this infographic, you will see the following information for Tnfrsf12a: database IDs, superfamily, protein function, synonyms, molecular weight, chromosomal locations, tissues of expression, subcellular locations, post-translational modifications, and related diseases, research areas & pathways. If you want to see more information included, or would like to contribute to it and be acknowledged, please contact [email protected].
Specific Publications For Anti-Fn14 TNFRSF12A Antibody (A06261)
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