Anti-Histone H2B H2BFS Antibody

Product Name

Anti-Histone H2B H2BFS Antibody

View all H2BFS Antibodies

SKU/Catalog Number

A12594

Size

100μl

Form

Liquid

Description

Boster Bio Anti-Histone H2B H2BFS Antibody catalog # A12594. Tested in WB applications. This antibody reacts with Human, Monkey, Mouse.

Storage & Handling

Store at -20°C for one year. For short term storage and frequent use, store at 4°C for up to one month. Avoid repeated freeze-thaw cycles.

Cite This Product

Anti-Histone H2B H2BFS Antibody (Boster Biological Technology, Pleasanton CA, USA, Catalog # A12594)

Host

Rabbit

Contents

Liquid in PBS containing 50% glycerol, 0.5% BSA and 0.02% sodium azide.

Clonality

Polyclonal

Clone Number

8D1

Isotype

IgG

Immunogen

Synthesized peptide derived from human Histone H2B around the non-acetylation site of K12. at AA rangle: 10-90

*Blocking peptide can be purchased. Costs vary based on immunogen length. Contact us for pricing.

Reactive Species

A12594 is reactive to H2BFS in Human, Monkey, Mouse

Applications

A12594 is guaranteed for WB Boster Guarantee

Observed Molecular Weight

Calculated molecular weight

13.944kDa

Background of H2BFS

COBRA1 (cofactor of BRCA1) also known as NELF-B, is an essential component of the negative elongation factor (NELF) complex. COBRA1 has been shown to directly bind estrogen receptor alpha (ERα) and repress ERα-mediated transcription (Aiyar SE et al., 2004). COBRA1 has also been demonstrated to interact with c-Jun and c-Fos suggesting a role in modulation of the AP-1 pathway and therefore may be important in cell proliferation, differentiation, apoptosis and oncogenesis (Zhong H et al., 2004)

Antibody Validation

Boster validates all antibodies on WB, IHC, ICC, Immunofluorescence, and ELISA with known positive control and negative samples to ensure specificity and high affinity, including thorough antibody incubations.

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Assay Dilutions Recommendation

The recommendations below provide a starting point for assay optimization. The actual working concentration varies and should be decided by the user.

WB, 1:500-1:2000

Validation Images & Assay Conditions

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Western Blot (WB) analysis of COS7 cells using Histone H2B Polyclonal antibody.

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Western Blot (WB) analysis of specific cells using Histone H2B Polyclonal antibody.

Gene/Protein Information For H2BFS (Source: Uniprot.org, NCBI)

Alternative Names

Histone H2B type F-S

For more info on H2BFS, check out the H2BFS Infographic

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In this infographic, you will see the following information for H2BFS: database IDs, superfamily, protein function, synonyms, molecular weight, chromosomal locations, tissues of expression, subcellular locations, post-translational modifications, and related diseases, research areas & pathways. If you want to see more information included, or would like to contribute to it and be acknowledged, please contact [email protected].

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