Product Info Summary
SKU: | PA1920 |
---|---|
Size: | 100 μg/vial |
Reactive Species: | Human |
Host: | Rabbit |
Application: | WB |
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Product info
Product Name
Anti-MALT1 Antibody
SKU/Catalog Number
PA1920
Size
100 μg/vial
Form
Lyophilized
Description
Boster Bio Anti-MALT1 Antibody catalog # PA1920. Tested in WB applications. This antibody reacts with Human.
Storage & Handling
Store at -20˚C for one year from date of receipt. After reconstitution, at 4˚C for one month. It can also be aliquotted and stored frozen at -20˚C for six months. Avoid repeated freeze-thaw cycles.
Cite This Product
Anti-MALT1 Antibody (Boster Biological Technology, Pleasanton CA, USA, Catalog # PA1920)
Host
Rabbit
Contents
Each vial contains 5mg BSA, 0.9mg NaCl, 0.2mg Na2HPO4, 0.05mg Thimerosal, 0.05mg NaN3.
Clonality
Polyclonal
Isotype
Rabbit IgG
Immunogen
A synthetic peptide corresponding to a sequence at the C-terminus of human MALT1.
*Blocking peptide can be purchased. Costs vary based on immunogen length. Contact us for pricing.
Cross-reactivity
No cross-reactivity with other proteins
Reactive Species
PA1920 is reactive to MALT1 in Human
Applications
PA1920 is guaranteed for WB Boster Guarantee
Observed Molecular Weight
22-24 kDa
Calculated molecular weight
92.272kDa
Background of MALT1
MALT1 (Mucosa-associated lymphoid tissue lymphoma translocation protein 1), also called MLT or PARACASPASE, is a protein that in humans is encoded by the MALT1 gene. This gene has been found to be recurrently rearranged in chromosomal translocation with two other genes - baculoviral IAP repeat-containing protein 3 (also known as apoptosis inhibitor 2) and immunoglobulin heavy chain locus - in mucosa-associated lymphoid tissue lymphomas. Dierlamm et al. (1999) and Akagi et al. (1999) mapped the MALT1 gene to chromosome 18q21. Using mouse models, Ruland et al. (2003) demonstrated that MALT1 is essential for T-cell activation, proliferation, and IL2 production in response to T-cell receptor ligation and strictly required for signal-specific NF-kappa-B (NFKB) activation induced by the T-cell receptor but not TNF-alpha or IL1 signaling. MALT1 operates downstream of BCL10, controls the catalytic activity of the canonical I-kappa-B kinase complex, and regulates the signaling of JNK and p38 MAP kinases.
Antibody Validation
Boster validates all antibodies on WB, IHC, ICC, Immunofluorescence, and ELISA with known positive control and negative samples to ensure specificity and high affinity, including thorough antibody incubations.
Innovating Scientists Reward
If you are the first to review this product, or if you have results for a special sample, species or application this product is not validated in, share your results with us and receive product credits you can use towards any Boster products! Applicable to all scientists worldwide.
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Assay dilution & Images
Reconsitution
Add 0.2ml of distilled water will yield a concentration of 500ug/ml.
Assay Dilutions Recommendation
The recommendations below provide a starting point for assay optimization. The actual working concentration varies and should be decided by the user.
Western blot, 0.1-0.5μg/ml, Human
Validation Images & Assay Conditions
Click image to see more details
Anti-MALT1 antibody, PA1920, Western blotting
Lane 1: MCF-7 Cell Lysate
Lane 2: HELA Cell Lysate
Protein Target Info & Infographic
Gene/Protein Information For MALT1 (Source: Uniprot.org, NCBI)
Gene Name
MALT1
Full Name
Mucosa-associated lymphoid tissue lymphoma translocation protein 1
Weight
92.272kDa
Superfamily
peptidase C14B family
Alternative Names
caspase-like protein; DKFZp434L132; EC 3.4.22.-; MALT associated translocation; MALT lymphoma-associated translocation; MALT1; MLT1; MLTMALT-lymphoma associated translocation; mucosa associated lymphoid tissue lymphoma translocation gene 1; mucosa-associated lymphoid tissue lymphoma translocation protein 1; Paracaspase MALT1 IMD12, MLT, MLT1, PCASP1 MALT1 paracaspase mucosa-associated lymphoid tissue lymphoma translocation protein 1|MALT1 protease|caspase-like protein|mucosa associated lymphoid tissue lymphoma translocation gene 1|paracaspase-1
*If product is indicated to react with multiple species, protein info is based on the gene entry specified above in "Species".For more info on MALT1, check out the MALT1 Infographic
We have 30,000+ of these available, one for each gene! Check them out.
In this infographic, you will see the following information for MALT1: database IDs, superfamily, protein function, synonyms, molecular weight, chromosomal locations, tissues of expression, subcellular locations, post-translational modifications, and related diseases, research areas & pathways. If you want to see more information included, or would like to contribute to it and be acknowledged, please contact [email protected].
Specific Publications For Anti-MALT1 Antibody (PA1920)
Hello CJ!
No publications found for PA1920
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Customer Reviews
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Customer Q&As
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1 Customer Q&As for Anti-MALT1 Antibody
Question
We are currently using anti-MALT1 antibody PA1920 for human tissue, and we are content with the WB results. The species of reactivity given in the datasheet says human. Is it possible that the antibody can work on canine tissues as well?
Verified Customer
Verified customer
Asked: 2019-12-26
Answer
The anti-MALT1 antibody (PA1920) has not been validated for cross reactivity specifically with canine tissues, but there is a good chance of cross reactivity. We have an innovator award program that if you test this antibody and show it works in canine you can get your next antibody for free. Please contact me if I can help you with anything.
Boster Scientific Support
Answered: 2019-12-26