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Product Info Summary
| SKU: | M00402 |
|---|---|
| Size: | 100ul |
| Reactive Species: | Human |
| Host: | Mouse |
| Application: | ELISA, IHC, WB |
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Product info
Product Name
Anti-MLL KMT2A Monoclonal Antibody
SKU/Catalog Number
M00402
Size
100ul
Form
Liquid
Description
Boster Bio Anti-MLL KMT2A Monoclonal Antibody catalog # M00402. Tested in ELISA, IHC, WB applications. This antibody reacts with Human.
Storage & Handling
Store at -20°C for one year. For short term storage and frequent use, store at 4°C for up to one month. Avoid repeated freeze-thaw cycles.
Cite This Product
Anti-MLL KMT2A Monoclonal Antibody (Boster Biological Technology, Pleasanton CA, USA, Catalog # M00402)
Host
Mouse
Contents
Ascitic fluid containing 0.03% sodium azide.
Clonality
Monoclonal
Clone Number
10F8D7
Isotype
IgG
Immunogen
Purified recombinant fragment of MLL (aa3751-3968) expressed in E. Coli.
*Blocking peptide can be purchased. Costs vary based on immunogen length. Contact us for pricing.
Reactive Species
M00402 is reactive to KMT2A in Human
Applications
M00402 is guaranteed for ELISA, IHC, WB Boster Guarantee
Observed Molecular Weight
Calculated molecular weight
431.764kDa
Background of KMT2A/MLL
Paired box protein Pax-6 also known as aniridia type II protein (AN2) or oculorhombin is a transcription factor with key functions in the development of the eye, nose, central nervous system and pancreas. Pax6 further seems to be required for the differentiation of pancreatic islet alpha cells. PAX6 has been shown to bind to a promoter element in the glucagon, insulin and somatostatin promoters and regulates the specification of the ventral neuron subtypes by establishing the correct progenitor domains. Isoform 5a appears to function as a molecular switch that specifies target genes. Anti-PAX6 antibody is ideal for researchers interested in developmental biology, stem cell research, cell growth and cancer research.
Antibody Validation
Boster validates all antibodies on WB, IHC, ICC, Immunofluorescence, and ELISA with known positive control and negative samples to ensure specificity and high affinity, including thorough antibody incubations.
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Assay dilution & Images
Assay Dilutions Recommendation
The recommendations below provide a starting point for assay optimization. The actual working concentration varies and should be decided by the user.
WB 1:500-1:2000
IHC 1:200-1:1000
ELISA 1:10000
Validation Images & Assay Conditions
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Figure 2. Immunohistochemistry validation of KMT2A using Anti-MLL KMT2A Monoclonal Antibody (M00402).
Immunohistochemistry (IHC) analysis of paraffin-embedded human lung cancer (left) and esophagus cancer (right)
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Figure 1. Western blotting validation for Anti-MLL KMT2A Monoclonal Antibody M00402
Western Blot (WB) analysis using MLL Monoclonal Antibody against truncated MLL recombinant protein (1) and truncated GFP-MLL(aa3714-3969) transfected Cos7 cell lysate (2).Electrophoresis was performed on a SDS-PAGE gel. To determine SDS-PAGE gel concentration
Protein Target Info & Infographic
Gene/Protein Information For KMT2A (Source: Uniprot.org, NCBI)
Gene Name
KMT2A
Full Name
Histone-lysine N-methyltransferase 2A
Weight
431.764kDa
Superfamily
class V-like SAM-binding methyltransferase superfamily
Alternative Names
ALL1; ALL-1MLL/GAS7; CXXC7TET1-MLL; CXXC-type zinc finger protein 7; EC 2.1.1.43; HRXFLJ11783; HTRX; HTRX1MLL-AF4 der(11) fusion protein; KMT2ACDK6/MLL fusion protein; Lysine N-methyltransferase 2A; MLL/GAS7 fusion protein; MLL/GMPS fusion protein; MLL1; MLL1A; myeloid/lymphoid or mixed-lineage leukemia (trithorax (Drosophila) homolog); myeloid/lymphoid or mixed-lineage leukemia (trithorax homolog, Drosophila); Trithorax-like protein; TRX1histone-lysine N-methyltransferase MLL; Zinc finger protein HRX KMT2A ALL-1, CXXC7, HRX, HTRX1, MLL, MLL1, MLL1A, TRX1, WDSTS lysine methyltransferase 2A histone-lysine N-methyltransferase 2A|CXXC-type zinc finger protein 7|lysine (K)-specific methyltransferase 2A|lysine N-methyltransferase 2A|mixed lineage leukemia 1|myeloid/lymphoid or mixed-lineage leukemia (trithorax homolog, Drosophila)|trithorax-like protein|zinc finger protein HRX
*If product is indicated to react with multiple species, protein info is based on the gene entry specified above in "Species".For more info on KMT2A, check out the KMT2A Infographic
We have 30,000+ of these available, one for each gene! Check them out.
In this infographic, you will see the following information for KMT2A: database IDs, superfamily, protein function, synonyms, molecular weight, chromosomal locations, tissues of expression, subcellular locations, post-translational modifications, and related diseases, research areas & pathways. If you want to see more information included, or would like to contribute to it and be acknowledged, please contact [email protected].
Specific Publications For Anti-MLL KMT2A Monoclonal Antibody (M00402)
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No publications found for M00402
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Customer Reviews
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