Anti-PAPP-A Antibody (Monoclonal, ABM4C62)

Product Name

Anti-PAPP-A Antibody (Monoclonal, ABM4C62)

View all Pappalysin-1/PAPP-A Antibodies

SKU/Catalog Number

M06838

Size

100 µg

Form

Liquid

Description

Boster Bio Anti-PAPP-A Antibody (Monoclonal, ABM4C62) (Catalog# M06838). Tested in IHC application(s). This antibody reacts with Human.

Storage & Handling

Store the antibody at 4°C, stable for 6 months. For long-term storage, store at -20°C. Avoid repeated freeze and thaw cycles.

Cite This Product

Anti-PAPP-A Antibody (Monoclonal, ABM4C62) (Boster Biological Technology, Pleasanton CA, USA, Catalog # M06838)

Host

Mouse

Contents

100 μg in 200 μl PBS containing 0.05% BSA and 0.05% sodium azide.

Clonality

Monoclonal

Clone Number

ABM4C62

Isotype

IgG2b Kappa

Immunogen

A partial length recombinant PAPP-A protein (amino acids 332-561)

*Blocking peptide can be purchased. Costs vary based on immunogen length. Contact us for pricing.

Cross-reactivity

Does not cross-react with primate, avian or amphibian GR.

Reactive Species

M06838 is reactive to PAPPA in Human

Applications

M06838 is guaranteed for IHC Boster Guarantee

Observed Molecular Weight

68 kDa

Calculated molecular weight

180.973kDa

Background of Pappalysin-1/PAPP-A

Keratin 15 is a type I keratin which is expressed only in basal keratinocytes in stratified epithelia and does not appear to have a natural type II expression partner. Keratin 15 is down regulated in activated keratinocytes. Cytokeratin 15 is a specific marker of stem cells of the hair-follicle bulge and may be a useful marker for diagnosis between basal cell carcinoma (BCC) and trichoepithelioma. Trichoblastoma are benign neoplasms of follicular differentiation frequently found in nevus sebaceous. Many morphologic features are shared with nodular basal cell carcinoma, sometimes rendering a diagnosis difficult. Trichoblastoma and BCC show variable expression of Cytokeratin 15 and Cytokeratin 19, and absence of hair keratins.

Antibody Validation

Boster validates all antibodies on WB, IHC, ICC, Immunofluorescence, and ELISA with known positive control and negative samples to ensure specificity and high affinity, including thorough antibody incubations.

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Reconsitution

Reconstitute with distilled water.

Assay Dilutions Recommendation

The recommendations below provide a starting point for assay optimization. The actual working concentration varies and should be decided by the user.

IHC: 5-10 µg/ml

Validation Images & Assay Conditions

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Immunohistochemical analysis of PAPP-A in human Placenta tissue using PAPP-A antibody (Clone: ABM4C62) at 5 &mu

Gene/Protein Information For PAPPA (Source: Uniprot.org, NCBI)

Alternative Names

ASBABP2; DIPLA1; EC 3.4.24.79; IGFBP-4ase; IGFBP-4aseaspecific BCL2 ARE-binding protein 2; IGF-dependent IGFBP-4 protease; insulin-like growth factor-dependent IGF binding protein-4 protease; Insulin-like growth factor-dependent IGF-binding protein 4 protease; PAPA; PAPPA; PAPPA1; PAPP-A1; PAPP-Adifferentially placenta 1 expressed protein; Pappalysin1; Pappalysin-1; pregnacy-associated plasma protein A; Pregnancy-associated plasma protein A; pregnancy-associated plasma protein A, pappalysin 1 PAPPA ASBABP2, DIPLA1, IGFBP-4ase, PAPA, PAPP-A1, PAPPA pappalysin 1 pappalysin-1|IGF-dependent IGFBP-4 protease|aspecific BCL2 ARE-binding protein 2|differentially placenta 1 expressed protein|insulin-like growth factor-dependent IGF binding protein-4 protease|pregnancy-associated plasma protein A, pappalysin 1

For more info on PAPPA, check out the PAPPA Infographic

We have 30,000+ of these available, one for each gene! Check them out.

In this infographic, you will see the following information for PAPPA: database IDs, superfamily, protein function, synonyms, molecular weight, chromosomal locations, tissues of expression, subcellular locations, post-translational modifications, and related diseases, research areas & pathways. If you want to see more information included, or would like to contribute to it and be acknowledged, please contact [email protected].

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