Anti-Phospho-NMD epsilon /2 (Y1246/1252) GRIN2A Antibody

Product Name

Anti-Phospho-NMD epsilon /2 (Y1246/1252) GRIN2A Antibody

View all GRIN2A Antibodies

SKU/Catalog Number

A01949Y1246

Size

100ul

Form

Liquid

Description

Boster Bio Anti-Phospho-NMD epsilon /2 (Y1246/1252) GRIN2A Antibody catalog # A01949Y1246. Tested in ELISA, IF, IHC applications. This antibody reacts with Human, Mouse, Rat.

Storage & Handling

Store at -20°C for one year. For short term storage and frequent use, store at 4°C for up to one month. Avoid repeated freeze-thaw cycles.

Cite This Product

Anti-Phospho-NMD epsilon /2 (Y1246/1252) GRIN2A Antibody (Boster Biological Technology, Pleasanton CA, USA, Catalog # A01949Y1246)

Host

Rabbit

Contents

Liquid in PBS containing 50% glycerol, 0.5% BSA and 0.02% sodium azide.

Clonality

Polyclonal

Isotype

IgG

Immunogen

Synthesized peptide derived from human NMDAepsilon1/2 around the phosphorylation site of Y1246/1252.

*Blocking peptide can be purchased. Costs vary based on immunogen length. Contact us for pricing.

Reactive Species

A01949Y1246 is reactive to GRIN2A in Human, Mouse, Rat

Applications

A01949Y1246 is guaranteed for ELISA, IF, IHC Boster Guarantee

Observed Molecular Weight

Calculated molecular weight

165.283kDa

Background of GRIN2A

Cullins assemble a potentially large number of ubiquitin ligases by binding to the RING protein ROC1 to catalyse polyubiquitination, as well as binding to various specificity factors to recruit substrates. Cullin 5 is a component of E3 ubiquitin ligase complexes, which mediate the ubiquitination and subsequent proteasomal degradation of target proteins. Cullin 5 seems to be involved proteosomal degradation of p53/TP53 stimulated by adenovirus E1B-55 kDa protein. Cullin 5 may form a cell surface vasopressin receptor. Cullin 5 is part of a E3 ubiquitin ligase complex with elongin BC complex (TCEB1 and TCEB2), RBX1 and MUF1, complexes with elongin BC complex (TCEB1 and TCEB2), RXB1 and TCEB3 or SOCS1 or WSB1; elongin BC complex (TCEB1 and TCEB2), RBX1 and VHL; elongin BC complex (TCEB1 and TCEB2), RBX1, adenovirus type 5 E1B-55kDa protein and adenovirus type 5 E4-orf6. Cullin 5 Interacts with RBX1 and RNF7.

Antibody Validation

Boster validates all antibodies on WB, IHC, ICC, Immunofluorescence, and ELISA with known positive control and negative samples to ensure specificity and high affinity, including thorough antibody incubations.

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Assay Dilutions Recommendation

The recommendations below provide a starting point for assay optimization. The actual working concentration varies and should be decided by the user.

IHC 1:100-1:300
IF 1:200-1:1000
ELISA 1:10000

Validation Images & Assay Conditions

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Figure 1. Immunohistochemistry validation of GRIN2A using Anti-Phospho-NMD epsilon /2 (Y1246/1252) GRIN2A Antibody (A01949Y1246).

Immunohistochemical analysis of paraffin-embedded Human brain. Antibody was diluted at 1:100 (4°C

Gene/Protein Information For GRIN2A (Source: Uniprot.org, NCBI)

Alternative Names

glutamate receptor, ionotropic, N-methyl D-aspartate 2A; hNR2A; NMDA receptor subtype 2A; N-methyl D-aspartate receptor subtype 2A; N-methyl-D-aspartate receptor subunit 2A; subunit epsilon-1 GRIN2A EPND, FESD, GluN2A, LKS, NMDAR2A, NR2A glutamate ionotropic receptor NMDA type subunit 2A glutamate receptor ionotropic, NMDA 2A|N-methyl D-aspartate receptor subtype 2A|N-methyl-D-aspartate receptor channel, subunit epsilon-1|N-methyl-D-aspartate receptor subunit 2A|glutamate ionotropic receptor NMDA 2A|glutamate receptor, ionotropic, N-methyl D-aspartate 2A

For more info on GRIN2A, check out the GRIN2A Infographic

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In this infographic, you will see the following information for GRIN2A: database IDs, superfamily, protein function, synonyms, molecular weight, chromosomal locations, tissues of expression, subcellular locations, post-translational modifications, and related diseases, research areas & pathways. If you want to see more information included, or would like to contribute to it and be acknowledged, please contact [email protected].

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