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Product Info Summary
| SKU: | A07774 |
|---|---|
| Size: | 0.1 mg |
| Reactive Species: | Human, Mouse, Rat |
| Host: | Rabbit |
| Application: | ELISA, IHC-P, WB |
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Product info
Product Name
Anti-Protein atonal homolog 8 ATOH8 Antibody
SKU/Catalog Number
A07774
Size
0.1 mg
Form
Liquid
Description
Boster Bio Anti-Protein atonal homolog 8 ATOH8 Antibody (Catalog # A07774). Tested in ELISA, WB, IHC-P applications. This antibody reacts with Human, Mouse, Rat.
Storage & Handling
ATOH8 antibody can be stored at 4°C for three months and -20°C, stable for up to one year. Avoid repeated freeze-thaw cycles. Antibodies should not be exposed to prolonged high temperatures.
Cite This Product
Anti-Protein atonal homolog 8 ATOH8 Antibody (Boster Biological Technology, Pleasanton CA, USA, Catalog # A07774)
Host
Rabbit
Contents
ATOH8 Antibody is supplied in PBS containing 0.02% sodium azide.
Clonality
Polyclonal
Isotype
IgG
Immunogen
ATOH8 antibody was raised against a 15 amino acid synthetic peptide near the carboxy terminus of human ATOH8. The immunogen is located within the last 50 amino acids of ATOH8.
*Blocking peptide can be purchased. Costs vary based on immunogen length. Contact us for pricing.
Cross-reactivity
DIS3L2 antibody is human, mouse and rat reactive. At least three isoforms of DIS3L2 are known to exist; this antibody will only detect the longest isoform. DIS3L2 is predicted to not cross-react with DIS3 or DIS3L.
Reactive Species
A07774 is reactive to Atoh8 in Human, Mouse, Rat
Applications
A07774 is guaranteed for ELISA, IHC-P, WB Boster Guarantee
Observed Molecular Weight
68 kDa
Calculated molecular weight
34.785kDa
Background of Atoh8
Basic helix-loop-helix (bHLH) transcription factors play important roles in differentiation processes during embryonic development of vertebrates. ATOH8 (MATH6) is a tissue-restricted member of the atonal superfamily of bHLH transcription factors that exhibits 43-57% identity in the bHLH domain with other mammalian atonal paralogs including the NeuroD and Neurogenin factors. In the mouse, ATOH8 has been implicated in the specification and differentiation of neuronal cell lineages in the brain and may also participate in kidney development. Recent studies show that ATOH8 is a novel component of the pancreatic transcriptional network during embryonic development and suggest a potential role as a modulator of the differentiation program initiated by the pro-endocrine factor Neurog3. It is indispensable for early embryonic development, suggesting a more widespread function for this factor in tissue-specific differentiation processes that are dependent on class II bHLH genes.
Antibody Validation
Boster validates all antibodies on WB, IHC, ICC, Immunofluorescence, and ELISA with known positive control and negative samples to ensure specificity and high affinity, including thorough antibody incubations.
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Assay dilution & Images
Assay Dilutions Recommendation
The recommendations below provide a starting point for assay optimization. The actual working concentration varies and should be decided by the user.
ATOH8 antibody can be used for detection of ATOH8 by Western blot at 1 - 2 μg/mL. Antibody can also be used for immunohistochemistry starting at 5 μg/mL.
Antibody validated: Western Blot in mouse samples and Immunohistochemistry in mouse samples. All other applications and species not yet tested. Optimal dilutions for each application should be determined by the researcher.
Validation Images & Assay Conditions
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Western blot analysis of ATOH8 in A-20 cell lysate with ATOH8 antibody at (A) 1 and (B) 2 μg/mL.
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Immunohistochemistry of ATOH8 in mouse brain tissue with ATOH8 antibody at 5 μg/mL.
Protein Target Info & Infographic
Gene/Protein Information For Atoh8 (Source: Uniprot.org, NCBI)
Gene Name
Atoh8
Full Name
Protein atonal homolog 8
Weight
34.785kDa
Alternative Names
ATH6; atonal homolog 6; atonal homolog 8 (Drosophila); basic helix-loop-helix transcription factor 6; BHLHA21; bHLHa21basic helix loop helix transcription factor 6; Class A basic helix-loop-helix protein 21; FLJ14708; FLJ38730; HATH6; Helix-loop-helix protein hATH-6; protein atonal homolog 8 Atoh8|4933425C05Rik, Hath6, Math, Math6, bHLHa, bHLHa21, ok, okadin|atonal bHLH transcription factor 8|protein atonal homolog 8|atonal homolog 8|basic helix-loop-helix transcription factor 6|helix-loop-helix protein mATH-6
*If product is indicated to react with multiple species, protein info is based on the gene entry specified above in "Species".For more info on Atoh8, check out the Atoh8 Infographic
We have 30,000+ of these available, one for each gene! Check them out.
In this infographic, you will see the following information for Atoh8: database IDs, superfamily, protein function, synonyms, molecular weight, chromosomal locations, tissues of expression, subcellular locations, post-translational modifications, and related diseases, research areas & pathways. If you want to see more information included, or would like to contribute to it and be acknowledged, please contact [email protected].
Specific Publications For Anti-Protein atonal homolog 8 ATOH8 Antibody (A07774)
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No publications found for A07774
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