Product Info Summary
SKU: | M10789 |
---|---|
Size: | 0.1 mg |
Reactive Species: | Human, Mouse |
Host: | Mouse |
Application: | Flow Cytometry, WB |
Customers Who Bought This Also Bought
Product info
Product Name
Anti-RLTPR Purified CARMIL2 Monoclonal Antibody
SKU/Catalog Number
M10789
Size
0.1 mg
Form
Liquid
Description
Boster Bio Anti-RLTPR Purified CARMIL2 Monoclonal Antibody (Catalog# M10789). Tested in Flow Cytometry, WB application(s). This antibody reacts with Mouse, Human.
Storage & Handling
Store at 2-8°C. Do not freeze.
Cite This Product
Anti-RLTPR Purified CARMIL2 Monoclonal Antibody (Boster Biological Technology, Pleasanton CA, USA, Catalog # M10789)
Host
Mouse
Contents
Phosphate buffered saline (PBS), pH 7.4, 15 mM sodium azide
Clonality
Monoclonal
Clone Number
EM-53
Isotype
Mouse IgG1 kappa
Immunogen
Murine RLTPR. The mouse monoclonal antibody EM-53 recognizes RLTPR / CARMIL2, an intracellular protein playing a role in actin filament elongation.
*Blocking peptide can be purchased. Costs vary based on immunogen length. Contact us for pricing.
Cross-reactivity
As in case with other anti-CD170 antibodies, this antibody cross-reacts with Siglec-14, whose first two Ig domains are almost identical to those of CD170.
Reactive Species
M10789 is reactive to CARMIL2 in Human, Mouse
Applications
M10789 is guaranteed for Flow Cytometry, WB Boster Guarantee
Observed Molecular Weight
42 kDa
Calculated molecular weight
154.689kDa
Background of CARMIL2
RLTPR / CARMIL2 (RGD motif, leucine rich repeats, tropomodulin domain and proline-rich containing; capping protein regulator and myosin 1 linker 2), also known as LRRC16C, is a cytosolic protein, which with high affinity binds CAPZA2 (capping protein muscle actin Z-line alpha 2) and decreases CAPZA2 affinity for actin barbed ends. RLTPR / CARMIL2 increases the rate of actin filament elongation from seeds in the presence of CAPZA2, however, seems unable to nucleate filaments. Its interaction with CAPZA2 is essential for lamellipodial protrusion and cell translocation. RLTPR / CARMIL2 is crutial for T cell costimulation via CD28 and this property seems to be independent on its actin-uncapping function. The lack of functional RLTPR / CARMIL2 molecules impeded the differentiation toward Th1 and Th17 fates of both human and murine CD4+ T cells and leads to combined immunodeficiency. Expression of RLTPR / CARMIL2 was also detected in human and murine B cells, but it seems not to be involved in BCR-mediated signaling.
Antibody Validation
Boster validates all antibodies on WB, IHC, ICC, Immunofluorescence, and ELISA with known positive control and negative samples to ensure specificity and high affinity, including thorough antibody incubations.
Innovating Scientists Reward
If you are the first to review this product, or if you have results for a special sample, species or application this product is not validated in, share your results with us and receive product credits you can use towards any Boster products! Applicable to all scientists worldwide.
Submit A Review
Assay dilution & Images
Assay Dilutions Recommendation
The recommendations below provide a starting point for assay optimization. The actual working concentration varies and should be decided by the user.
Flow cytometry: 1-4 µg/ml. Intracellular staining.
Validation Images & Assay Conditions
There are currently no images for this product. We are working on uploading them please check back shortly or contact us to expedite our upload process for this antibody.
Protein Target Info & Infographic
Gene/Protein Information For CARMIL2 (Source: Uniprot.org, NCBI)
Gene Name
CARMIL2
Full Name
Capping protein, Arp2/3 and myosin-I linker protein 2
Weight
154.689kDa
Superfamily
CARMIL family
Alternative Names
Capping protein, Arp2/3 and myosin-I linker protein 2 CARMIL2 CARMIL2b, IMD58, LRRC16C, RLTPR capping protein regulator and myosin 1 linker 2 capping protein, Arp2/3 and myosin-I linker protein 2|F-actin-uncapping protein RLTPR|RGD motif, leucine rich repeats, tropomodulin domain and proline-rich containing|RGD, leucine-rich repeat, tropomodulin and proline-rich containing protein|leucine rich repeat containing 16C|leucine-rich repeat-containing protein 16C
*If product is indicated to react with multiple species, protein info is based on the gene entry specified above in "Species".For more info on CARMIL2, check out the CARMIL2 Infographic
We have 30,000+ of these available, one for each gene! Check them out.
In this infographic, you will see the following information for CARMIL2: database IDs, superfamily, protein function, synonyms, molecular weight, chromosomal locations, tissues of expression, subcellular locations, post-translational modifications, and related diseases, research areas & pathways. If you want to see more information included, or would like to contribute to it and be acknowledged, please contact [email protected].
Specific Publications For Anti-RLTPR Purified CARMIL2 Monoclonal Antibody (M10789)
Hello CJ!
No publications found for M10789
*Do you have publications using this product? Share with us and receive a reward. Ask us for more details.
Recommended Resources
Here are featured tools and databases that you might find useful.
- Boster's Pathways Library
- Protein Databases
- Bioscience Research Protocol Resources
- Data Processing & Analysis Software
- Photo Editing Software
- Scientific Literature Resources
- Research Paper Management Tools
- Molecular Biology Software
- Primer Design Tools
- Bioinformatics Tools
- Phylogenetic Tree Analysis
Customer Reviews
Have you used Anti-RLTPR Purified CARMIL2 Monoclonal Antibody?
Submit a review and receive an Amazon gift card.
- $30 for a review with an image
Be the first to review Anti-RLTPR Purified CARMIL2 Monoclonal Antibody
*The first user to submit a review for a product is eligible for Boster's Innovating Scientists Reward, which gives product credits. This is in addition to the gift card reward.
Customer Q&As
Have a question?
Find answers in Q&As, reviews.
Can't find your answer?
Submit your question