Anti-SmarcAL1 Antibody

Product Name

Anti-SmarcAL1 Antibody

View all SMARCAL1 Antibodies

SKU/Catalog Number

A03383

Size

100ug

Form

Liquid (sterile filtered)

Description

Boster Bio Anti-SmarcAL1 Antibody (Catalog # A03383). Tested in ELISA, WB applications. This antibody reacts with Human.

Storage & Handling

Store vial at -20°C prior to opening. Aliquot contents and freeze at -20°C or below for extended storage. Avoid cycles of freezing and thawing. Centrifuge product if not completely clear after standing at room temperature. This product is stable for several weeks at 4°C as an undiluted liquid. Dilute only prior to immediate use. Expiration date is one (1) year from date of opening.

Cite This Product

Anti-SmarcAL1 Antibody (Boster Biological Technology, Pleasanton CA, USA, Catalog # A03383)

Host

Rabbit

Contents

0.02 M Potassium Phosphate, 0.15 M Sodium Chloride, pH 7.2, 0.01% (w/v) Sodium Azide

Clonality

Polyclonal

Isotype

IgG

Immunogen

This affinity purified antibody was prepared from whole rabbit serum produced by repeated immunizations with a synthetic peptide corresponding to an internal near aa 75-100 of human SmarcAL1 protein.

*Blocking peptide can be purchased. Costs vary based on immunogen length. Contact us for pricing.

Cross-reactivity

No cross reactivity with other proteins.

Reactive Species

A03383 is reactive to SMARCAL1 in Human

Applications

A03383 is guaranteed for ELISA, WB Boster Guarantee

Observed Molecular Weight

Calculated molecular weight

105.938kDa

Background of SMARCAL1

SmarcAL1 (SWI/SNF-related µatrix-associated actin-dependent regulator of chromatin a-like 1) is also known as HARP, HepA Related Protein, HHARP, SMARCA like Protein 1 and SWI/SNF Related. SmarcAL1 is a member of the SWI/SNF family of proteins. Members of this family have helicase and ATPase activities and are thought to regulate transcription of certain genes by altering the chromatin structure around those genes. The encoded protein shows sequence similarity to the E. coli RNA polymerase-binding protein HepA. Mutations in this gene are a cause of Schimke immunoosseous dysplasia (SIOD), an autosomal recessive disorder with the diagnostic features of spondyloepiphyseal dysplasia, renal dysfunction, and T-cell immunodeficiency.

Antibody Validation

Boster validates all antibodies on WB, IHC, ICC, Immunofluorescence, and ELISA with known positive control and negative samples to ensure specificity and high affinity, including thorough antibody incubations.

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Assay Dilutions Recommendation

The recommendations below provide a starting point for assay optimization. The actual working concentration varies and should be decided by the user.

ELISA: 1:16,000 - 1:64,000
WB: 1:500 - 1:3,000

Validation Images & Assay Conditions

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Western blot analysis of SmarcAL1 expression in HeLa nuclear extract (lane 1), HeLa whole cell lysates (lane 2), A431 whole cell lysates (lane 3), Jurkat whole cell lysates (lane 4) and 293 whole cell lystaes (lane 5). SmarcAL1 at 106KD was detected using rabbit anti-SmarcAL1 Antigen Affinity purified polyclonal antibody (Catalog # A03383) at 1:500. The blot was developed using chemiluminescence (ECL) method (Catalog # EK1002).

Gene/Protein Information For SMARCAL1 (Source: Uniprot.org, NCBI)

Alternative Names

ATP-driven annealing helicase; EC 3.6.1; EC 3.6.4.-; HARPSWI/SNF-related matrix-associated actin-dependent regulator of chromatinsubfamily A-like protein 1; HepA-related protein; HHARP; SIOD; SMARCA-like protein 1; subfamily a-like 1; Sucrose nonfermenting protein 2-like 1; SWI/SNF related, matrix associated, actin dependent regulator of chromatin SMARCAL1 HARP, HHARP SWI/SNF related, matrix associated, actin dependent regulator of chromatin, subfamily a like 1 SWI/SNF-related matrix-associated actin-dependent regulator of chromatin subfamily A-like protein 1|ATP-driven annealing helicase|HepA-related protein|SMARCA-like protein 1|sucrose nonfermenting protein 2-like 1

For more info on SMARCAL1, check out the SMARCAL1 Infographic

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In this infographic, you will see the following information for SMARCAL1: database IDs, superfamily, protein function, synonyms, molecular weight, chromosomal locations, tissues of expression, subcellular locations, post-translational modifications, and related diseases, research areas & pathways. If you want to see more information included, or would like to contribute to it and be acknowledged, please contact [email protected].

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