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Product Info Summary
| SKU: | A10510 |
|---|---|
| Size: | 0.1 mg |
| Reactive Species: | Human |
| Host: | Rabbit |
| Application: | ELISA, IHC-P, WB |
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Product info
Product Name
Anti-TEM4 ARHGEF17 Antibody
SKU/Catalog Number
A10510
Size
0.1 mg
Form
Liquid
Description
Boster Bio Anti-TEM4 ARHGEF17 Antibody (Catalog # A10510). Tested in ELISA, WB, IHC-P applications. This antibody reacts with Human.
Storage & Handling
TEM4 antibody can be stored at 4°C for three months and -20°C, stable for up to one year. Avoid repeated freeze-thaw cycles. Antibodies should not be exposed to prolonged high temperatures.
Cite This Product
Anti-TEM4 ARHGEF17 Antibody (Boster Biological Technology, Pleasanton CA, USA, Catalog # A10510)
Host
Rabbit
Contents
TEM4 Antibody is supplied in PBS containing 0.02% sodium azide.
Clonality
Polyclonal
Isotype
IgG
Immunogen
TEM4 antibody was raised against a 18 amino acid synthetic peptide near the center of human TEM4. The immunogen is located within amino acids 910 - 960 of TEM4.
*Blocking peptide can be purchased. Costs vary based on immunogen length. Contact us for pricing.
Cross-reactivity
BHLHA15 antibody is human, mouse and rat reactive.
Reactive Species
A10510 is reactive to ARHGEF17 in Human
Applications
A10510 is guaranteed for ELISA, IHC-P, WB Boster Guarantee
Observed Molecular Weight
68 kDa
Calculated molecular weight
221.673kDa
Background of TEM4
Rho GTPases, which are activated by specific guanine-nucleotide exchange factors (GEFs), play pivotal roles in several cellular functions. TEM4, encoding a protein containing 1510 amino acids, contains a RhoGEF-specific Dbl homology (DH) domain but lacks their typical pleckstrin homology domain. TEM4 is a Rho-specific GEF with novel structural and regulatory properties and predominant expression in the heart. It couples tyrosine kinase signals with the activation of the rho/rac GTPases, thus leading to cell differentiation and/or proliferation. Elevated levels of TEM4, TEM5, TEM6, TEM7 and TEM7R were also raised in breast cancer tissues. TEM4 could also prove to be useful targets therapeutically.
Antibody Validation
Boster validates all antibodies on WB, IHC, ICC, Immunofluorescence, and ELISA with known positive control and negative samples to ensure specificity and high affinity, including thorough antibody incubations.
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Assay dilution & Images
Assay Dilutions Recommendation
The recommendations below provide a starting point for assay optimization. The actual working concentration varies and should be decided by the user.
TEM4 antibody can be used for detection of TEM4 by Western blot at 0.5 - 1 μg/mL. Antibody can also be used for immunohistochemistry starting at 2.5 μg/mL. For immunofluorescence start at 20 μg/mL.
Antibody validated: Western Blot in human samples and Immunohistochemistry in human samples. All other applications and species not yet tested. Optimal dilutions for each application should be determined by the researcher.
Validation Images & Assay Conditions
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Western blot analysis of TEM4 in Jurkat cell lysate with TEM4 antibody at (A) 0.5 and (B) 1 μg/mL.
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Immunohistochemistry of TEM4 in human spleen tissue with TEM4 antibody at 2.5 μg/mL.
Protein Target Info & Infographic
Gene/Protein Information For ARHGEF17 (Source: Uniprot.org, NCBI)
Gene Name
ARHGEF17
Full Name
Rho guanine nucleotide exchange factor 17
Weight
221.673kDa
Alternative Names
164 kDa Rho-specific guanine-nucleotide exchange factor; FLJ90019; KIAA0337P164RHOGEF; p164RhoGEF; p164-RhoGEFRho-specific guanine-nucleotide exchange factor 164 kDa; Rho guanine nucleotide exchange factor (GEF) 17; TEM4rho guanine nucleotide exchange factor 17; Tumor endothelial marker 4 ARHGEF17 P164RHOGEF, RHOGEF17, TEM4, p164-RhoGEF Rho guanine nucleotide exchange factor 17 rho guanine nucleotide exchange factor 17|164 kDa Rho-specific guanine-nucleotide exchange factor|Rho guanine nucleotide exchange factor (GEF) 17|Rho-specific guanine-nucleotide exchange factor 164 kDa|tumor endothelial marker 4
*If product is indicated to react with multiple species, protein info is based on the gene entry specified above in "Species".For more info on ARHGEF17, check out the ARHGEF17 Infographic
We have 30,000+ of these available, one for each gene! Check them out.
In this infographic, you will see the following information for ARHGEF17: database IDs, superfamily, protein function, synonyms, molecular weight, chromosomal locations, tissues of expression, subcellular locations, post-translational modifications, and related diseases, research areas & pathways. If you want to see more information included, or would like to contribute to it and be acknowledged, please contact [email protected].
Specific Publications For Anti-TEM4 ARHGEF17 Antibody (A10510)
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No publications found for A10510
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