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Product Info Summary
| SKU: | A07164 |
|---|---|
| Size: | 0.1 mg |
| Reactive Species: | Human, Mouse, Rat |
| Host: | Rabbit |
| Application: | ELISA, IF, IHC-P, WB |
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Product info
Product Name
Anti-TRESK KCNK18 Antibody
SKU/Catalog Number
A07164
Size
0.1 mg
Form
Liquid
Description
Boster Bio Anti-TRESK KCNK18 Antibody (Catalog # A07164). Tested in ELISA, WB, IHC-P, IF applications. This antibody reacts with Human, Mouse, Rat.
Storage & Handling
TRESK antibody can be stored at 4°C for three months and -20°C, stable for up to one year. Avoid repeated freeze-thaw cycles. Antibodies should not be exposed to prolonged high temperatures.
Cite This Product
Anti-TRESK KCNK18 Antibody (Boster Biological Technology, Pleasanton CA, USA, Catalog # A07164)
Host
Rabbit
Contents
TRESK Antibody is supplied in PBS containing 0.02% sodium azide.
Clonality
Polyclonal
Clone Number
Clone: SK7
Isotype
IgG
Immunogen
TRESK antibody was raised against a 17 amino acid synthetic peptide from near the center of human TRESK. The immunogen is located within amino acids 210 - 260 of TRESK.
*Blocking peptide can be purchased. Costs vary based on immunogen length. Contact us for pricing.
Cross-reactivity
GBP5 antibody is predicted to not cross-react with other GBP family members.
Reactive Species
A07164 is reactive to Kcnk18 in Human, Mouse, Rat
Applications
A07164 is guaranteed for ELISA, IF, IHC-P, WB Boster Guarantee
Observed Molecular Weight
68 kDa
Calculated molecular weight
44.403kDa
Background of Kcnk18
TRESK (TWIK-related spinal cord K+ channel) is a two-pore domain K+ channel that induces outward rectification and functions as a background K+ channel that is abundantly expressed in the spinal cord, thymus, spleen, and leukemic T-lymphocytes. TRESK is activated by increased cytoplasmic calcium concentration through calcineurin as well as by acetylcholine and histamine. It has been suggested that TRESK is linked to acute and chronic pain by activation of calcineurin. Other studies indicate that TRESK may play a role in the regulation of T-cell function and could be an excellent target to treat T-cell originated immune dysfunction.
Antibody Validation
Boster validates all antibodies on WB, IHC, ICC, Immunofluorescence, and ELISA with known positive control and negative samples to ensure specificity and high affinity, including thorough antibody incubations.
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Assay dilution & Images
Assay Dilutions Recommendation
The recommendations below provide a starting point for assay optimization. The actual working concentration varies and should be decided by the user.
TRESK antibody can be used for detection of TRESK by Western blot at 1 - 2 μg/mL. Antibody can also be used for immunohistochemistry starting at 5 μg/mL. For immunofluorescence start at 20 μg/mL.
Antibody validated: Western Blot in rat samples; Immunohistochemistry in rat samples and Immunofluorescence in rat samples. All other applications and species not yet tested. Optimal dilutions for each application should be determined by the researcher.
Validation Images & Assay Conditions
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Western blot analysis of TRESK in rat brain tissue lysate with TRESK antibody at (A) 1 and (B) 2 μg/mL.
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Immunohistochemistry of TRESK in rat brain tissue with TRESK antibody at 5 μg/mL.
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Immunofluorescence of TRESK in Rat Brain cells with TRESK antibody at 20 μg/mL.
Protein Target Info & Infographic
Gene/Protein Information For Kcnk18 (Source: Uniprot.org, NCBI)
Gene Name
Kcnk18
Full Name
Potassium channel subfamily K member 18
Weight
44.403kDa
Superfamily
two pore domain potassium channel (TC 1.A.1.8) family
Alternative Names
K2p18.1; potassium channel subfamily K member 18; potassium channel, subfamily K, member 18; TRESK2; TRESK-2; TRESKTWIK-related spinal cord potassium channel; TRIKMGR13; TWIK-related individual K+ channel; TWIK-related individual potassium channel; TWIK-related spinal cord K+ channel Kcnk18|Gm781, Tre, Tresk, Tresk-2, Trik|potassium channel, subfamily K, member 18|potassium channel subfamily K member 18|2P K ion channel TRESK|TWIK-related individual K+ channel|TWIK-related spinal cord K+ channel|two-pore-domain potassium channel TRESK
*If product is indicated to react with multiple species, protein info is based on the gene entry specified above in "Species".For more info on Kcnk18, check out the Kcnk18 Infographic
We have 30,000+ of these available, one for each gene! Check them out.
In this infographic, you will see the following information for Kcnk18: database IDs, superfamily, protein function, synonyms, molecular weight, chromosomal locations, tissues of expression, subcellular locations, post-translational modifications, and related diseases, research areas & pathways. If you want to see more information included, or would like to contribute to it and be acknowledged, please contact [email protected].
Specific Publications For Anti-TRESK KCNK18 Antibody (A07164)
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No publications found for A07164
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