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Product Info Summary
| SKU: | A07266 |
|---|---|
| Size: | 0.1 mg |
| Reactive Species: | Human, Mouse, Rat |
| Host: | Rabbit |
| Application: | ELISA, WB |
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Product info
Product Name
Anti-UEV1A UBE2V1 Antibody
View all Uev1a/UBE2V1 Antibodies
SKU/Catalog Number
A07266
Size
0.1 mg
Form
Liquid
Description
Boster Bio Anti-UEV1A UBE2V1 Antibody (Catalog # A07266). Tested in ELISA, WB applications. This antibody reacts with Human, Mouse, Rat.
Storage & Handling
UEV1A antibody can be stored at 4°C for three months and -20°C, stable for up to one year. Avoid repeated freeze-thaw cycles. Antibodies should not be exposed to prolonged high temperatures.
Cite This Product
Anti-UEV1A UBE2V1 Antibody (Boster Biological Technology, Pleasanton CA, USA, Catalog # A07266)
Host
Rabbit
Contents
UEV1A Antibody is supplied in PBS containing 0.02% sodium azide.
Clonality
Polyclonal
Isotype
IgG
Immunogen
UEV1A antibody was raised against a peptide corresponding to 15 amino acids near the C-terminus of human UEV1A. The immunogen is located within the last 50 amino acids of UEV1A.
*Blocking peptide can be purchased. Costs vary based on immunogen length. Contact us for pricing.
Cross-reactivity
Anti-UEV1A may also recognize other isoforms of UEV1A.
Reactive Species
A07266 is reactive to UBE2V1 in Human, Mouse, Rat
Applications
A07266 is guaranteed for ELISA, WB Boster Guarantee
Observed Molecular Weight
68 kDa
Calculated molecular weight
16.495kDa
Background of Uev1a/UBE2V1
Ubiquitin-conjugating enzyme E2 (UEV1) was initially discovered as a protein similar in sequence and structure to the E2 ubiquitin-conjugating enzymes but lacking their enzymatic activity. There are at least two variants and multiple isoforms of UEV1. In particular, UEV1A (Ubiquitin-conjugating enzyme E2 variant 1 isoform A) has recently been shown to be an important component of the Toll-like receptor and IL-1R signaling pathway. Signals from these pathways are relayed by a number of downstream molecules such as MyD88 and tumor necrosis factor receptor associated factor (TRAF6), ultimately activating various kinases and transcription factors. UEV1A is part of a dimeric ubiquitin-conjugating enzyme complex also containing Ubc13 (ubiquitin-conjugating enzyme 13) that together with TRAF6 activates TAK1, a member of the mitogen-activated protein kinase kinase kinase family. The Ubc13-UEV1A complex also mediates the Lys-63 ubiquitination of TRAF-6, and this ubiquitination is essential for TAK1 activation.
Antibody Validation
Boster validates all antibodies on WB, IHC, ICC, Immunofluorescence, and ELISA with known positive control and negative samples to ensure specificity and high affinity, including thorough antibody incubations.
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Assay dilution & Images
Assay Dilutions Recommendation
The recommendations below provide a starting point for assay optimization. The actual working concentration varies and should be decided by the user.
UEV1A antibody can be used for detection of UEV1A by Western blot at 1 to 4 μg/mL.
Antibody validated: Western Blot in human samples. All other applications and species not yet tested. Optimal dilutions for each application should be determined by the researcher.
Validation Images & Assay Conditions
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Western blot analysis of UEV1A in Jurkat cell lysates with UEV1A antibody at (A) 1
Protein Target Info & Infographic
Gene/Protein Information For UBE2V1 (Source: Uniprot.org, NCBI)
Gene Name
UBE2V1
Full Name
Ubiquitin-conjugating enzyme E2 variant 1
Weight
16.495kDa
Superfamily
ubiquitin-conjugating enzyme family
Alternative Names
CIR1; CROC1; CROC1TRAF6-regulated IKK activator 1 beta Uev1A; CROC-1UBE2V; UBE2V1; ubiquitin-conjugating enzyme E2 variant 1; Uev1a; UEV-1CIR1; UEV1DNA-binding protein UBE2V1 CIR1, CROC-1, CROC1, UBE2V, UEV-1, UEV1, UEV1A ubiquitin conjugating enzyme E2 V1 ubiquitin-conjugating enzyme E2 variant 1|DNA-binding protein|TRAF6-regulated IKK activator 1 beta Uev1A
*If product is indicated to react with multiple species, protein info is based on the gene entry specified above in "Species".For more info on UBE2V1, check out the UBE2V1 Infographic
We have 30,000+ of these available, one for each gene! Check them out.
In this infographic, you will see the following information for UBE2V1: database IDs, superfamily, protein function, synonyms, molecular weight, chromosomal locations, tissues of expression, subcellular locations, post-translational modifications, and related diseases, research areas & pathways. If you want to see more information included, or would like to contribute to it and be acknowledged, please contact [email protected].
Specific Publications For Anti-UEV1A UBE2V1 Antibody (A07266)
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