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Product Info Summary
| SKU: | A07706 |
|---|---|
| Size: | 0.1 mg |
| Reactive Species: | Human |
| Host: | Rabbit |
| Application: | ELISA, IF, IHC-P, WB |
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Product info
Product Name
Anti-ULK3 Antibody
SKU/Catalog Number
A07706
Size
0.1 mg
Form
Liquid
Description
Boster Bio Anti-ULK3 Antibody (Catalog # A07706). Tested in ELISA, WB, IHC-P, IF applications. This antibody reacts with Human.
Storage & Handling
ULK3 antibody can be stored at 4°C for three months and -20°C, stable for up to one year.
Cite This Product
Anti-ULK3 Antibody (Boster Biological Technology, Pleasanton CA, USA, Catalog # A07706)
Host
Rabbit
Contents
ULK3 antibody is supplied in PBS containing 0.02% sodium azide.
Clonality
Polyclonal
Clone Number
Clone: SK7
Isotype
IgG
Immunogen
ULK3 antibody was raised against a 19 amino acid peptide near the center of human ULK3. The immunogen is located within amino acids 230 - 280 of ULK3.
*Blocking peptide can be purchased. Costs vary based on immunogen length. Contact us for pricing.
Cross-reactivity
ULK3 antibody is human specific. Multiple isoforms of ULK3 are known to exist.
Reactive Species
A07706 is reactive to ULK3 in Human
Applications
A07706 is guaranteed for ELISA, IF, IHC-P, WB Boster Guarantee
Observed Molecular Weight
68 kDa
Calculated molecular weight
53.444kDa
Background of ULK3
ULK3 belongs to the Ser/Thr protein kinase superfamily and plays a role in the ATP-dependent phosphorylation of target proteins (1). Knockout of ULK genes results in a severe defect in the autophagy pathway (2). ULK3, like the other Unc-51-like kinases such as ULK1, ULK2 and ULK4, is highly conserved among eukaryotes (3). ULK3 has been shown to be a positive regulator of the Hedgehog signaling pathway by enhancing GLI1 and GLI2 transcriptional activity (4). Furthermore, ULK3 can also interact with SUFU, a protein required for the negative regulation of GLI proteins; this interaction blocks the autophosphorylation of ULK3 and blocks its ability to regulate the GLI proteins (5).
Antibody Validation
Boster validates all antibodies on WB, IHC, ICC, Immunofluorescence, and ELISA with known positive control and negative samples to ensure specificity and high affinity, including thorough antibody incubations.
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Assay dilution & Images
Assay Dilutions Recommendation
The recommendations below provide a starting point for assay optimization. The actual working concentration varies and should be decided by the user.
ULK3 antibody can be used for detection of ULK3 by Western blot at 0.5 - 1 μg/ml. Antibody can also be used for Immunohistochemistry starting at 5 μg/mL. For immunofluorescence start at 20 μg/mL.
Antibody validated: Western Blot in human samples; Immunohistochemistry in human samples and Immunofluorescence in human samples. All other applications and species not yet tested. Optimal dilutions for each application should be determined by the researcher.
Validation Images & Assay Conditions
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Western blot analysis of ULK3 in human brain tissue lysate with ULK3 antibody at (A) 0.5 and (B) 1 μg/ml.
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Immunohistochemistry of ULK3 in human brain tissue with ULK3 antibody at 5 μg/mL.
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Immunofluorescence of ULK3 in human brain tissue with ULK3 antibody at 20 μg/mL.
Protein Target Info & Infographic
Gene/Protein Information For ULK3 (Source: Uniprot.org, NCBI)
Gene Name
ULK3
Full Name
Serine/threonine-protein kinase ULK3
Weight
53.444kDa
Superfamily
protein kinase superfamily
Alternative Names
DKFZP434C131; EC 2.7.11.1; FLJ90566; serine/threonine-protein kinase ULK3; unc-51-like kinase 3 (C. elegans); Unc-51-like kinase 3 ULK3 unc-51 like kinase 3 serine/threonine-protein kinase ULK3
*If product is indicated to react with multiple species, protein info is based on the gene entry specified above in "Species".For more info on ULK3, check out the ULK3 Infographic
We have 30,000+ of these available, one for each gene! Check them out.
In this infographic, you will see the following information for ULK3: database IDs, superfamily, protein function, synonyms, molecular weight, chromosomal locations, tissues of expression, subcellular locations, post-translational modifications, and related diseases, research areas & pathways. If you want to see more information included, or would like to contribute to it and be acknowledged, please contact [email protected].
Specific Publications For Anti-ULK3 Antibody (A07706)
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No publications found for A07706
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Customer Reviews
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