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Boster Bio Life Science Blog
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Welcome to the latest issue of Research Spotlight! We're excited to dive into biomedical breakthroughs that are impacting health and disease research.
In the field of neuroscience, research revealed how stress affects the brain, particularly the red nucleus, and its link to anxiety and immune responses. This insight has implications for treating mental health disorders. In respiratory research, a new study advanced our understanding of how the lungs detect allergens, opening up possibilities...
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Welcome to this month’s Research Spotlight! In this issue, we are excited to showcase our customers’ new studies that are shaping the future of biomedicine.
In the field of neurology, researchers investigated a critical pathway, p300/NF-κB/NLRP3, impacted by disruptions in chaperone-mediated autophagy, which holds promise for treatments in neurodegenerative diseases. For regenerative medicine, scientists introduced a metal-organic framework-incorporated hydrogel that...
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As autumn leaves turn golden, Boster Bio is excited to present a medley of pioneering studies that have recently been published. This month’s issue covers a spectrum from novel therapeutic interventions to insightful multi-omics analyses.
In the therapeutic domain, we spotlight a novel implantable hydrogel-based sensor that allows for real-time drug monitoring in rats. We also observe a shift in cancer treatments with a new cocktail nanovaccine. Additionally, fresh approaches are introduced for targeting lung fibrosis using mitochondrial transfer and enhancing liver cancer treatments with artesunate.
On a molecular scale, studies revealed how indoor air pollutants impact liver health and blood lipid levels. Scientists also investigated the protective role of gut fungi against intestinal issues and the potential of mung bean sprout nanoparticles in diabetes management. Moreover, recent findings linked a compound in the colon, phosphocholine, with a specific fungus Candida tropicalis, highlighting mycobiota’s importance for our digestive health.
Scroll down to learn more about these discoveries!
Implantable Hydrogel-Protective DNA Aptamer-Based Sensor Supports Accurate, Continuous Electrochemical Analysis of Drugs at Multiple Sites in Living Rats
Authors: Li, S., Dai, J., Zhu, M., Currás, N.A., Li, H., Wang, Y., Wang, Q…
Journal: ACS NanoThe ability to track the levels of specific molecules, such as drugs, metabolites, and biomarkers, in the living body, in real time and for long durations, would improve our understanding of health and our ability to diagnose, treat, and monitor disease. To this end, we are developing electrochemical aptamer-based (EAB) biosensors...
Cited Boster Product(s): Rat IL-12(P70) ELISA Kit PicoKine® (EK1652); Rat Endothelin 1/EDN1 ELISA Kit PicoKine® (EK0952)
Efficient Intervention for Pulmonary Fibrosis via Mitochondrial Transfer Promoted by Mitochondrial Biogenesis
Authors: Huang, T., Lin, R., Su, Y., Sun, H., Zheng, X., Zhang, J., Lu, X…
Journal: Nature CommunicationsThe use of exogenous mitochondria to replenish damaged mitochondria has been proposed as a strategy for the treatment of pulmonary fibrosis. However, the success of this strategy is partially restricted by the difficulty of supplying sufficient mitochondria to diseased cells. Herein, we report the generation of high-powered mesenchymal...
Cited Boster Product(s): Mouse MMP-9 ELISA Kit PicoKine® (EK0466); Mouse TGF Beta 1 ELISA Kit PicoKine® (EK0515); 4% Paraformaldehyde (PFA) Solution In PBS (AR1068); Anti-Ki67/MKI67 Antibody Picoband™ (PB9026); Goat Anti-Rabbit IgG (H+L) Secondary Antibody, FITC Conjugated (BA1105)
In Situ Cocktail Nanovaccine for Cancer Immunotherapy
Authors: Liu, M., Xie, D., Hu, D., Zhang, R., Wang Y., Tang, L., Zhou, B…
Journal: Advanced ScienceIn situ vaccination is a desirable strategy for cancer immunotherapy due to its convenience and capacity to target tumor antigens. Here, an in situ nanovaccine based on a cationic peptide with cholesterol-modified, DP7-C, for cancer immunotherapy is rationally designed, and developed a cancer nanovaccine that is easy to preparate...
Cited Boster Product(s): Mouse TNF Alpha/Tumor Necrosis Factor ELISA Kit PicoKine® (EK0527)
Artesunate Sensitizes Human Hepatocellular Carcinoma to Sorafenib via Exacerbating AFAP1L2-SRC-FUNDC1 Axis-Dependent Mitophagy
Authors: Ma, Z., Chen, W., Liu, Y., Yu, L., Mao, X., Guo, X., Jiang, F., Guo, Q…
Journal: AutophagySorafenib is the most widely used first-line drug for the treatment of the advanced hepatocellular carcinoma (HCC). Unfortunately, sorafenib resistance often limits its therapeutic efficacy. To evaluate the efficacy of artesunate against sorafenib-resistant HCC and to investigate its underlying pharmacological mechanisms...
Cited Boster Product(s): Citrate Buffer Powder (AR0024)
Global Analysis of HLA-A2 Restricted MAGE-A3 Tumor Antigen Epitopes and Corresponding TCRs in Non-Small Cell Lung Cancer
Authors: Zhang, B., Ren, Z., Zhao, J., Zhu, Y., Huang, B., Xiao, C., Zhang, Y…
Journal : TheranosticsBackground: Advanced non-small cell lung cancer (NSCLC) is the most common type of lung cancer with poor prognosis. Adoptive cell therapy using engineered T-cell receptors (TCRs) targeting cancer-testis antigens, such as Melanoma-associated antigen 3 (MAGE-A3), is a potential approach for the treatment of NSCLC. However, systematic...
Cited Boster Product(s): HRP Conjugated AffiniPure Goat Anti-Rabbit IgG (H+L) (BA1054)
...Multi-Omics Analysis Reveals Hepatic Lipid Metabolism Profiles and Serum Lipid Biomarkers Upon Indoor Relevant VOC Exposure
Authors: Miao, G., Wang, Y., Wang, B., Yu, H., Liu, J., Pan, R., Zhou, C…
Journal: Environment InternationalAs a widespread indoor air pollutant, volatile organic compound (VOC) caused various adverse health effects, especial the damage to liver, which has become a growing public concern. However, the current toxic data are intrinsically restricted in the single or major VOC species. Limited knowledge is available regarding toxic effects...
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Welcome to this month's Research Spotlight where we delve into an array of exciting scientific discoveries!
For the field of neuroscience, scientists examined the significance of G3BP2-Tau interaction for Tau aggregation as well as the role of SMN for neurodegeneration. In gastroenterology, researchers presented modified prebiotic-based probiotics as a novel approach for treating colitis. Furthermore, another study offered insights into the connections between gut microbiota and diabetic...
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We're delighted to bring you another issue of our Research Spotlight newsletter, showcasing the most recent papers our customers have published. These studies widen biological understanding and pave pathways for innovative therapies.
This month, we delve into a broad spectrum of biomedical research studies. We highlight research examining the intricate roles of the PD-L1/PD-1 pathway in neuroscience and the use of 3D bioprinting for biomimetic hydrogel scaffolds. Scientists demonstrate...
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Welcome to the June issue of Research Spotlight! We are happy to feature 10 selected publications from scientists whom Boster has served.
Recent neurological research has uncovered the impact of glioblastoma on human neural circuits, providing insights into decreased survival. In oncology, researchers revealed the role of hepatic stellate cell stearoyl co-A desaturase in promoting liver tumorigenesis through the leukotriene B4 receptor 2 - β-catenin cascade.
Exciting advancements...
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We're delighted to present this month's research roundup, featuring studies from scientists we have served.
In this issue, dive into innovative cancer immunotherapy techniques using lipid rewiring nanoparticles to revitalize tumor-associated dendritic cells, uncover new mechanisms of antibiotic resistance in S. aureus, explore the potential of gut microbial b-galactosidase for alleviating liver damage, and examine the role of matrix stiffness in determining osteoclast fate...
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For our April issue of Research Spotlight, we’re happy to feature 10 recent publications from scientists whom Boster has served.
In one study, to prevent cardiac fibrosis after myocardial infarction (MI), researchers developed a reduced glutathione (GSH)-responsive nanoparticle platform for targeted drug delivery to activated cardiac fibroblasts (CFs) within the infarct area of a post-MI heart, which demonstrated higher therapeutic efficacy and lower systemic toxicity than systemic drug administration.
Another study investigated the osteo-immunomodulatory effects of bicalcium phosphate (BCP) ceramics coupled with micro-vibration stimulation (MVS). Our selected papers also include studies on bacterial outer membrane vesicles (OMVs) for intestinal homeostasis regulation, 3TC for protection against age-related cognitive dysfunction, and several more.
Scroll down to learn about exciting discoveries from top scientific journals!
Cysteine-Based Redox-Responsive Nanoparticles for Fibroblast-Targeted Drug Delivery in the Treatment of Myocardial Infarction
Authors: Ji, X., Meng, Y., Wang, Q., Tong, T., Liu, Z., Lin, J., Li, B., Wei, Y…
Journal: ACS NanoUpon myocardial infarction (MI), activated cardiac fibroblasts (CFs) begin to remodel the myocardium, leading to cardiac fibrosis and even heart failure. No therapeutic approaches are currently available to prevent the development of MI-induced pathological fibrosis. Most pharmacological trials fail from poor local drug activity...
Cited Boster Product(s): Anti-ACTA2/Alpha Smooth Muscle Actin Monoclonal Antibody (A01072)
Versatility of Bacterial Outer Membrane Vesicles in Regulating Intestinal Homeostasis
Authors: Wang, X., Lin, X., Wang, L., Cao, Z., Zhang, M., Zhang, Y., Liu, R...
Journal: Science AdvancesOuter membrane vesicles (OMVs) play vital roles in bacterial communication both intraspecifically and interspecifically. However, extracellular mechanisms of gut microbiota–derived OMVs in the intestine remain poorly understood. Here, we report that OMVs released from Akkermansia muciniphila are able to (i) restore disturbed...
Cited Boster Product(s): Mouse ACE2 ELISA Kit PicoKine® (EK1188)
Coupling BCP Ceramics with Micro-Vibration Stimulation Field for Cascade Amplification from Immune Activation to Bone Regeneration
Authors: Wu, J., Wang, M., Wu, Y., Liu, J., Zhi, W., Chen, X., Zhu, X., Zhang, X.
Journal: Advanced Functional MaterialsThe osteoimmunology has revealed that immune system plays an important role in maintaining bone metabolism and remodeling. As long-term physiological factor in bone, mechanical stimulation such as micro-vibration stimulation (MVS) exerts effects on regulating osteogenesis and immune response. In this study, the osteo-immunodulatory...
Cited Boster Product(s): RIPA Lysis Buffer (AR0105-100)
The Rhythmic Coupling of Egr-1 and Cidea Regulates Age-Related Metabolic Dysfunction in the Liver of Male Mice
Authors: Wu, J., Bu, D., Wang, H., Shen, D., Chong, D., Zhang, T., Tao, W…
Journal: Nature CommunicationsThe liver lipid metabolism of older individuals canbecome impaired and the circadian rhythm of genes involved in lipid metabolism is also disturbed. Although the link between metabolism and circadian rhythms is already recognized, how these processes are decoupled in liver during aging is still largely unknown...
Cited Boster Product(s): HRP Conjugated AffiniPure Goat Anti-Rabbit IgG (H+L) (BA1054); HRP Conjugated AffiniPure Goat Anti-Mouse IgG (H+L) (BA1050)
The Reverse Transcriptase Inhibitor 3TC Protects Against Age-Related Cognitive Dysfunction
Authors: Wahl, D., Smith, M.E., McEntee, C.M., Cavalier, A.N., Osburn, S.C…
Journal: Aging CellAging is the primary risk factor for most neurodegenerative diseases, including Alzheimer's disease. Major hallmarks of brain aging include neuroinflammation/immune activation and reduced neuronal health/function. These processes contribute to cognitive dysfunction (a key risk factor for Alzheimer's disease)...
Cited Boster Product(s): Multiplex ELISA Kit For Mouse Cytokine Panel 2 (4-Plex) (MEK1016)
...Sphingosine-1-Phosphate Receptor 4 Attenuates Neutrophilic Airway Inflammation in Experimental
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Welcome to the March issue of Research Spotlight! This month, we present an array of research papers offering new insights for cutting-edge biomedical technologies.
One research study describes a novel nanostructure with magnetocaloric oscillation and catalytic effects for pyroptosis-triggered tumor immunotherapy. Another study investigates a brain-targeted peptide-functionalized chitosan nanoparticle for resveratrol delivery, showing promise in combating obesity-related Alzheimer's...
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In our February issue of Research Spotlight, we feature 10 recent publications from scientists whom Boster has served.
This month, several studies highlight the potential of nanotechnology innovations such as EPC-secreted exosomes, NIR-responsive hollow germanium nanospheres, berberin-enriched PLGA nanoparticles, and nanofiber-based meshes for improving the therapeutic output of nanomedicines.
Scientists also investigated how different groups of bioactive compounds, such as polyamine, vimentin, and dietary genistein exhibit immunomodulatory effects on the molecular pathways involved in the immune response against various disease conditions. In addition, novel roles for components of the SP3/PAD4 and miR-139-5p/ECE1 pathways in disease progression are discussed.
Scroll down to learn more about the research studies!
...Manipulating Bioactivities of Endothelial Progenitor Cell-derived Exosomes for Promoting Angiogenesis in Ischemic Vascular Diseases
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