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Boster Bio Life Science Blog
Discover the latest advances in biomedical research through our monthly spotlight series. Dive into cutting-edge discoveries—from immunotherapies to nanotech innovations—that are redefining life science.
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In our March edition of Research Spotlight, we present 10 latest research papers from scientists whom Boster has served.
Scientists explore the roles of various pathways associated with tumor development, and how they may emerge as new therapeutic targets for tumor metastasis. Several research studies also reveal the active role of gut microbiota in immunity and disease progressions as well as the effect of several compounds on the functionality and ecology of gut microbiome.
Take a look below to learn more about these new research findings.
...Fecal Microbiota Transplantation in HIV: A Pilot Placebo-Controlled Study
Authors: Serrano-Villar, S., Talavera-Rodríguez, A., Gosalbes, M.J., Madrid, N...
Journal: Nature CommunicationsChanges in the microbiota have been linked to persistent inflammation during treated HIV infection. In this pilot double-blind study, we study 30 HIV-infected subjects on antiretroviral therapy (ART) with a CD4/CD8 ratio less than 1 randomized to either weekly fecal microbiota capsules or placebo for 8 weeks. Stool donors were rationally...
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The February edition of Research Spotlight provides 10 recent research discoveries from scientists whom Boster has served, which include new insights on the interactions between nanoparticles and human health as well as the underlying mechanisms.
The pathology-improvement effects of siRNA-based drugs on lung disorders, trichostatin A on Alzheimer’s disease, and propofol on microglial phagocytosis were also explored.
Scroll down to find out more about each featured publication.
...Combined Exposure of Alumina Nanoparticles and Chronic Stress Exacerbates Hippocampal Neuronal Ferroptosis via Activating IFN-γ/ASK1/JNK Signaling Pathway in Rats
Authors: Zhang, H., Jiao, W., Cui, H., Sun, Q., & Fan, H.
Journal : Journal of Hazardous MaterialsAlumina nanoparticles (AlNPs) exposure causes hippocampal-dependent cognitive dysfunction. However, whether chronic stress exacerbates AlNPs-induced hippocampal lesion and its mechanism remains unclear. This study was aimed to investigate the combined effects and mechanisms of AlNPs and chronic stress on the hippocampal lesion. The...
Cited Boster Product(s): Rat TNF Alpha ELISA Kit PicoKine™ (EK0526); Rat IL-1
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Our January edition of Research Spotlight presents an array of 10 interesting developments in the biomedical world. Valuable information about proliferation of cancer cells, immunity, inflammatory bowel diseases, and the body’s responses to oxidative stress and various nutrients are discussed.
In addition, scientists investigate how SLC19A1 as the major transporter of CDNs into cells could serve as a new potential immunotherapeutic treatment of cancer and some inflammatory diseases...
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The December edition of Research Spotlight highlights 10 recent research discoveries from scientists whom Boster has served.
In these studies, the effects of several key proteins and their signaling pathways were explored in correlation to the progression and activation of cancer cells, diabetic nephropathy, inflammation, and brain injury.
The role of polysulfides as potential tumor suppressors and regulators might represent an alternative therapeutic candidate for the management of diabetic nephropathy. Additionally, several promising potential therapeutic strategies for enhanced immunotherapy, such as enhanced drug delivery systems, ultrasound-guided platelet-rich plasma injection, and the role of mechanical cues in vascular biology were also investigated.
Scroll down to find more information about these new scientific discoveries.
Polysulfide-Mediated Sulfhydration of SIRT1 Prevents Diabetic Nephropathy by Suppressing Phosphorylation and Acetylation of p65 NF-κB and STAT3
Authors: Sun, H.J., Xiong, S.P., Cao, X., Cao, L., Zhu, M.Y., Wu, Z.Y., & Bian, J.S.
Journal: Redox BiologyDiabetic kidney disease is known as a major cause of chronic kidney disease and end stage renal disease. Polysulfides, a class of chemical agents with a chain of sulfur atoms, are found to confer renal protective effects in acute kidney injury. However, whether a polysulfide donor, sodium tetrasulfide (Na2S4), confers protective...
Cited Boster Product(s): Mouse TNF Alpha ELISA Kit PicoKine™ (EK0527); Mouse IL-1 Beta ELISA Kit PicoKine™ (EK0394); Mouse VCAM-1 ELISA Kit PicoKine™ (EK0538)
...Development of Thermosensitive Resiquimod-Loaded Liposomes for Enhanced Cancer Immunotherapy
Authors: Zhang, H., Tang, W.L., Kheirolomoom, A., Fite, B.Z., Wu, B., Lau, K...
Journal: Journal of Controlled ReleaseResiquimod (R848) is a toll-like receptor 7 and 8 (TLR7/8) agonist with potent antitumor and immunostimulatory activity. Howeve
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In our November edition of Research Spotlight, we feature 10 recently published research papers from scientists whom Boster has served.
This month’s selected research publications investigate how several cells and mediators regulate the development of fibrotic diseases, cancer, inflammatory responses, diabetes, allergy, endometriosis, and anxiety.
Among the studies, scientists propose the underlying mechanisms of how endothelin receptor antagonists may serve as a therapeutic strategy for fibrotic diseases. The role of PRMT5 in laryngeal tumor carcinogenesis is also explored.
Discover more details about these new scientific discoveries below.
...Second-Strand Synthesis-Based Massively Parallel scRNA-Seq Reveals Cellular States and Molecular Features of Human Inflammatory Skin Pathologies
Authors: Hughes, T.K., Wadsworth, M.H., Gierahn, T.M., Do, T., Weiss, D...
Journal: ImmunityHigh-throughput single-cell RNA-sequencing (scRNA-seq) methodologies enable characterization of complex biological samples by increasing the number of cells that can be profiled contemporaneously. Nevertheless, t
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The October edition of Research Spotlight features 10 recent research discoveries from scientists whom Boster has served.
This month’s research publications examine treatments and mechanisms for cancers such as breast cancer, colitis-associated cancer, and ovarian cancer. Scientists also propose stem cell derived biomimetic vesicles for versatile and effective targeted delivery. In addition, researchers investigate how dihydroartemisinin (DHA) can ameliorate psoriatic skin inflammation.
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...GSH Depletion Liposome Adjuvant for Augmenting the Photothermal Immunotherapy of Breast Cancer
Authors: Zhou, Z., Wu, H., Yang, R., Xu, A., Zhang, Q., Dong, J., Qian, C., & Sun, M.
Journal: Science AdvancesThe high redox level of tumor microenvironment inhibits the oxidation treatment and the immune response. Here, we innovatively develop maleimide liposome (ML) adjuvants to promote immunogenic cell death (ICD) induction and dendritic cells (DCs) maturation by glutathione (GSH) depletion for augmenting the photothermal immunotherapy...
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In our September edition of Research Spotlight, we feature 10 recently published research papers from scientists whom Boster has served.
This month’s selected research publications examine the mechanisms of plaque rupture, ELABELA in DOCA/salt-induced hypertension, BMSC-derived exosomes in peripheral nerve regeneration, TMZ in diabetic nephropathy, and MCL on LPS-induced inflammation.
Among the studies, scientists also investigate nanomicelle’s effect on paclitaxel’s immune-activation ability. In addition, the connection of cancer-associated SNPs in lncRNA for lung cancer and the role of IL-6 for colorectal cancer are explored.
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...Nanomicelle protects the immune activation effects of Paclitaxel and sensitizes tumors to anti-PD-1 Immunotherapy
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The August edition of Research Spotlight features 10 recent research discoveries from scientists whom Boster has served.
This month’s research publications investigate heart regeneration in zebrafish, the protection of adipose-derived stem cells against UVB-induced skin photoaging, the neuroprotective effect of Z. bungeanum pericarps, electroacupuncture treatment of visceral hypersensitivity, etc.
In addition, scientists explore the mechanisms of several disorders, such as intestinal barrier injury, alcohol-associated hepatocellular carcinoma, and activated astrocytes’ roles in chronic post-surgical pain (CPSP).
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p53 soform 113p53 promotes zebrafish heart regeneration by maintaining redox homeostasis
Authors: Ye, S., Zhao, T., Zhang, W., Tang, Z., Gao, C., Ma, Z., Xiong, J.W., Peng, J...
Journal: Cell Death & DiseaseNeonatal mice and adult zebrafish can fully regenerate their hearts through proliferation of pre-existing cardiomyocytes. Previous studies have revealed that p53 signalling is activated during cardiac regeneration in neonatal mice and that hydrogen peroxide (H2O2) generated near the wound site acts as a novel signal to promote...
Cited Boster Product(s): Anti-HIF-1 Alpha/HIF1A Antibody Picoband™ (A00013-1)
...Indoxyl sulfate induces intestinal barrier injury through IRF1-DRP1 axis mediated mitophagy impairment
Authors: Huang, Y., Zhou, J., Wang, S., Xiong, J., Chen, Y., Liu, Y., Xiao, T., Li, Y…
Journal: TheranosticsThe dysfunctional gut-kidney axis forms a vicious circle, which eventually becomes a catalyst for the progression of chronic kidney disease (CKD) and occurrence of related complications. However, the pathogenic factors of CKD-associated intestinal dysfunction and its mechanism remain elusive. We first identified the protein-bound uremic...
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In our July edition of Research Spotlight, we feature 10 recently published research papers from scientists whom Boster has served.
This month’s research publications examine different types of cancers, including ovarian cancer, breast cancer, colorectal cancer, etc. Scientists also delve into other research fields, such as intervertebral disc (IVD) degeneration, wound healing, and type 2 diabetes.
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Accumulation of advanced glycation end products (AGEs) is associated with the severity of aortic stenosis in patients with concomitant type 2 diabetes
Authors: Kopytek, M., Ząbczyk, M., Mazur, P., Undas, A., & Natorska, J.
Journal: Cardiovascular DiabetologyAccumulation of advanced glycation end products (AGEs) leads to chronic glycation of proteins and tissue damage, particularly in patients with diabetes mellitus (DM). We aimed to evaluate whether increased accumulation of AGEs in patients with aortic stenosis (AS) and concomitant type 2 diabetes (DM) is associated with AS severity...
Cited Boster Product(s): Human Rage ELISA Kit PicoKine™ (EK0827)
Antitumor effect of a WEE1 inhibitor and potentiation of olaparib sensitivity by DNA damage response modulation in triple-negative breast cancer
Authors: Ha, D.H., Min, A., Kim, S., Jang, H., Kim, S.H., Kim, H.J., Ryu, H.S, Ku, J.L...
Journal: Scientific ReportsDue to its regulation of CDK1/2 phosphorylation, WEE1 plays essentially roles in the regulations of G2/M checkpoint and DNA damage response (DDR). WEE1 inhibition can increase genomic instability by inducing replication stress and G2/M checkpoint inactivation, which result in increased cellular sensitivity to DNA damaging agents...
Cited Boster Product(s): Anti-Phospho-Cdc2 (Tyr15) CDK1 Antibody (P00209)
...Cortistatin protects against intervertebral disc degeneration through targeting mitochondrial ROS-dependent NLRP3 inflammasome activation
Authors: Zhao, Y., Qiu, C., Wang, W., Peng, J., Cheng, X., Shangguan, Y., Xu, M., Li, J...
Journal: TheranosticsBackground: Intervertebral disc (IVD) degeneration is a common degenerative disease that can lead to collapse or herniation of the nucleus pulposus (NP) and result in radiculopathy in patients. Methods: NP tissue and cells were isolated from patients and mice, and the expression profile of cortistatin (CST) was analysed. In addition...
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The June edition of Research Spotlight features 10 recent research discoveries from scientists whom Boster has served.
This month’s selected research publications investigate several cancers and diseases, including hepatocellular carcinoma, hepatitis B, prostate cancer, ankylosing spondylitis, rheumatoid arthritis, and diabetes.
Among the studies, scientists propose a prodrug for inflammatory diseases as well as a tumor nanovaccine that utilizes electrostatic interactions. The relationship of depression with inflammation and metabolic dysfunction in addition to ketamine’s potential anti-depressive effects are also explored.
Scroll down to learn more about these new scientific discoveries.
A hydrogen peroxide responsive prodrug of Keap1-Nrf2 inhibitor for improving oral absorption and selective activation in inflammatory conditions
Authors: Lu, M., Zhang, X., Zhao, J., You, Q., & Jiang, Z.
Journal: Redox BiologyTranscription factor Nuclear factor erythroid 2-related factor 2 (Nrf2) and its negative regulator, the E3 ligase adaptor Kelch-like ECH-associated protein 1 (Keap1), control the redox and metabolic homeostasis and oxidative stress. Inhibitors of Keap1-Nrf2 interaction are promising in oxidative stress related inflammatory diseases but now hit hurdles. By utilizing...
Cited Boster Product(s): Mouse IL-1 Beta ELISA Kit PicoKine™ (EK0394); Mouse IL-6 ELISA Kit PicoKine™ (EK0411); Mouse TNF Alpha ELISA Kit PicoKine™ (EK0527)
...The immunoglobulin superfamily member 3 (IGSF3) promotes hepatocellular carcinoma progression through activation of the NF-κB pathway
Authors: Sheng, P., Zhu, H., Zhang, W., Xu, Y., Peng, W., Sun, J., Gu, M., & Jiang, H.
Journal: Annals of Translational MedicineBackground: Patients with hepatocellular carcinoma (HCC) suff
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