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Bile salt export pump Antibodies
AND ABCB11 ELISA kits, Bile salt export pump Proteins
Many biological assays use antibodies to detect Bile salt export pump, such as Western Blot (WB), ELISA, Flow Cytometry, Immunocytochemistry (IHC). These antibodies can be polyclonal or monoclonal, and react with Bile salt export pump in Human, Mouse, Rat, and many other animal samples. Boster Bio use mainly mouse and rabbit to develop Bile salt export pump antibodies...
Designing a Western blot for Bile salt export pump? The guide has the expected band size, antibodies backed by real blot images, the controls to run alongside, and protocols taken from published papers.
Open the ABCB11 Western Blot GuideABCB11 Infographic by Boster Bio
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ABCB11 Overview
Facts about Bile salt export pump.
Bile salt export pump (ABCB11)
Involved from the ATP-dependent secretion of bile salts into the canaliculus of hepatocytes. .
Gene Information
| Human | |
|---|---|
| Gene Name: | ABCB11 |
| Uniprot: | O95342 |
| Entrez: | 8647 |
Family
| Belongs to: |
|---|
| ABC transporter superfamily |
Alternative Names
ABC member 16, MDR/TAP subfamily; ABC16; ATP-binding cassette sub-family B member 11; ATP-binding cassette, sub-family B (MDR/TAP), member 11; bile salt export pump; BSEP; BSEPPFIC2; EC 3.6.3; EC 3.6.3.44; PFIC-2; PGY4; progressive familial intrahepatic cholestasis 2; sister p-glycoprotein; SPGPBRIC2
Molecular Weight
Mass (kDA):
146.407 kDA
Genomic Context
| Human | |
|---|---|
| Location: | 2q31.1 |
| Sequence: | 2; NC_000002.12 (168915468..169031396, complement) |
Tissue Specificity
Expressed predominantly, if not exclusively in the liver, where it was further localized to the canalicular microvilli and to subcanalicular vesicles of the hepatocytes by in situ.
Subcellular Localizations
Membrane; Multi-pass membrane protein.
Diseases
- Cholestasis
- Intrahepatic Cholestasis
- Progressive Intrahepatic Cholestasis (disorder)
- Liver Diseases
- Cholestasis Of Pregnancy
- Pregnancy Complications
- Liver Cirrhosis
- Injury To Liver
- Pruritus
- Cholestasis, Progressive Familial Intrahepatic, 2
- Liver Carcinoma
- Cholecystolithiasis
Pathways
- Transport
- Secretion
- Excretion
- Localization
- Pathogenesis
- Bile Acid Secretion
- Acid Secretion
- Cholesterol Transport
- Gallstone Formation
- Reverse Cholesterol Transport
- Cholesterol Homeostasis
- Drug Resistance
- Cholesterol Efflux
PTMs
- Phosphorylation
- Glycosylation
- Methylation
- Acetylation
- Amidation
- Ubiquitination
For details, visit:
bosterbio.com/bosterbio-gene-info-cards/ABCB11
bosterbio.com/bosterbio-gene-info-cards/ABCB11
References
PMID: 9806540 by Strautnieks S.S., et al. A gene encoding a liver-specific ABC transporter is mutated in progressive familial intrahepatic cholestasis.
PMID: 16332456 by Hayashi H., et al. Transport by vesicles of glycine- and taurine-conjugated bile salts and taurolithocholate 3-sulfate: a comparison of human BSEP with rat Bsep.
2 Publications of Boster Bile salt export pump Antibodies & ELISA Kits
- PubMed ID: 10.1016/j.bbalip.2021.159006, Hypercholesterolemia risk associated Abca6 does not regulate lipoprotein metabol...
- PubMed ID: 10.1016/j.bbadis.2020.165994, The zonula occludens protein family regulates the hepatic barrier system in the ...
*More publications can be found for each product on its corresponding product page