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- Table of Contents
ABCC2 Antibodies
AND ABCC2 ELISA kits, ABCC2 Proteins
Many biological assays use antibodies to detect ABCC2, such as Western Blot (WB), ELISA, Flow Cytometry, Immunocytochemistry (IHC). These antibodies can be polyclonal or monoclonal, and react with ABCC2 in Human, Mouse, Rat, and many other animal samples. Boster Bio use mainly mouse and rabbit to develop ABCC2 antibodies...
Designing a Western blot for ABCC2? The guide has the expected band size, antibodies backed by real blot images, the controls to run alongside, and protocols taken from published papers.
Open the ABCC2 Western Blot GuideDesigning an IHC experiment for ABCC2? The guide has the expected staining pattern, antigen retrieval and fixation, antibodies backed by real IHC images, the tissue controls to run alongside, and protocols taken from published papers.
Open the ABCC2 IHC GuideABCC2 Infographic by Boster Bio
All ABCC2 Products
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Specificity
Applications
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ABCC2 Overview
Facts about Canalicular multispecific organic anion transporter 1.
Canalicular multispecific organic anion transporter 1 (ABCC2)
Mediates hepatobiliary excretion of numerous organic anions. May be the cellular cisplatin transporter.
.
Gene Information
| Human | |
|---|---|
| Gene Name: | ABCC2 |
| Uniprot: | Q92887 |
| Entrez: | 1244 |
Family
| Belongs to: |
|---|
| ABC transporter superfamily |
Alternative Names
ATP-binding cassette, sub-family C (CFTR/MRP), member 2; Canalicular multidrug resistance protein; canalicular multispecific organic anion transporter 1; CMOAT1; CMOATABC30; cMRP; DJS; KIAA1010; MRP2ATP-binding cassette sub-family C member 2; Multidrug resistance-associated protein 2
Molecular Weight
Mass (kDA):
174.207 kDA
Genomic Context
| Human | |
|---|---|
| Location: | 10q24.2 |
| Sequence: | 10; NC_000010.11 (99782602..99853741) |
Tissue Specificity
Expressed by polarized cells in liver, kidney and intestine. The highest expression is found in liver.
Subcellular Localizations
Apical cell membrane; Multi-pass membrane protein.
Diseases
- Malignant Neoplasms
- Malignant Neoplasm Of Breast
- Neoplasms
- Hyperbilirubinemia
- Cholestasis
- Carcinoma
- Jaundice, Chronic Idiopathic
- Liver Carcinoma
- Liver Diseases
- Epilepsy
- Hepatotoxicity
- Mammary Neoplasms
- Hiv Infections
Interacting Proteins
- NFKB1
Pathways
- Transport
- Excretion
- Localization
- Secretion
- Drug Resistance
- Drug Transport
- Conjugation
- Intestinal Absorption
- Organic Anion Transport
- Anion Transport
- Pathogenesis
- Dna Repair
- Transepithelial Transport
PTMs
- Phosphorylation
- Hydroxylation
- Glycosylation
- Carboxylation
- Biotinylation
- Reduction
- Methylation
Research Areas
- ABC Transporters
- Amino Acids, Drugs and other small molecules
- Cancer
- Diabetes Research
- Lipid and Metabolism
For details, visit:
bosterbio.com/bosterbio-gene-info-cards/ABCC2
bosterbio.com/bosterbio-gene-info-cards/ABCC2
References
PMID: 8797578 by Taniguchi K., et al. A human canalicular multispecific organic anion transporter (cMOAT) gene is overexpressed in cisplatin-resistant human cancer cell lines with decreased drug accumulation.
PMID: 8662992 by Buechler M., et al. cDNA cloning of the hepatocyte canalicular isoform of the multidrug resistance protein, cMrp, reveals a novel conjugate export pump deficient in hyperbilirubinemic mutant rats.
7 Publications of Boster ABCC2 Antibodies & ELISA Kits
- PubMed ID: 10.3892/ijo.2016.3442, Cisplatin-induced CCL5 secretion from CAFs promotes cisplatin-resistance in ovar...
- PubMed ID: 10.1186/1479-5876-6-55, Lentivirus-mediated RNAi silencing targeting ABCC2 increasing the sensitivity of...
- PubMed ID: 10.1155/2021/5566078, The Herbal Constituents in An-Gong-Niu-Huang Wan (AGNH) Protect against Cinnabar...
- PubMed ID: 10.1155/2010/915046, Association of ABCC2 and CDDP-Resistance in Two Sublines Resistant to CDDP Deriv...
- PubMed ID: -, Songsong Wang,Xiao Xiao,Ao Li,Peng Li,"The Herbal Constituents in An-Gong-Niu-Hu...
- PubMed ID: 33317360, Huang J,Wang Q,Chen M,Bi Y,Shi H,Zhou K. Effects of psoralen on hepatic bile aci...
- PubMed ID: 20628484, Association of ABCC2 and CDDP-resistance in two sublines resistant to CDDP deriv...
*More publications can be found for each product on its corresponding product page