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- Table of Contents
ADAMTS4 Antibodies
AND ADAMTS4 ELISA kits, ADAMTS4 Proteins
Many biological assays use antibodies to detect ADAMTS4, such as Western Blot (WB), ELISA, Flow Cytometry, Immunocytochemistry (IHC). These antibodies can be polyclonal or monoclonal, and react with ADAMTS4 in Human, Mouse, Rat, and many other animal samples. Boster Bio use mainly mouse and rabbit to develop ADAMTS4 antibodies...
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ADAMTS4 Infographic by Boster Bio
All ADAMTS4 Products
Product
Figures
Specificity
Applications
Price
Human ADAMTS4 ELISA Kit PicoKine®
3 Citations 9 Q&As
Human
ELISA
$499
Cat # EK1372
96 wells/kit, with removable strips.
Cat # EK1372
96 wells/kit, with removable strips.
Anti-ADAMTS4/ADAMTS4 Antibody Picoband®
1 Citations 1 Q&As
Human, Mouse, Rat
WB
$370
Cat # PA1479
100 μg/vial
Cat # PA1479
100 μg/vial
Human, Mouse, Rat
IHC, WB
$523
Cat # M02899
100 µl
Cat # M02899
100 µl
ADAMTS4 Overview
Facts about A disintegrin and metalloproteinase with thrombospondin motifs 4.
A disintegrin and metalloproteinase with thrombospondin motifs 4 (ADAMTS4)
Cleaves aggrecan, a cartilage proteoglycan, and may be involved in its turnover. May play an essential role in the destruction of aggrecan in arthritic diseases.
Could also be a critical element in the exacerbation of neurodegeneration in Alzheimer disease. Cleaves aggrecan in the'392-Glu-.
Gene Information
| Human | |
|---|---|
| Gene Name: | ADAMTS4 |
| Uniprot: | O75173 |
| Entrez: | 9507 |
Family
| Belongs to: |
|---|
| No superfamily |
Alternative Names
a disintegrin-like and metalloprotease (reprolysin type) with thrombospondintype 1 motif, 4; ADAM metallopeptidase with thrombospondin type 1 motif, 4; ADAM-TS 4; ADAMTS2; ADAMTS-2; ADAMTS4; ADAM-TS4; ADAMTS-4; ADMP-1; ADMP-1EC 3.4.24.82; Aggrecanase 1; aggrecanase-1; EC 3.4.24; KIAA0688A disintegrin and metalloproteinase with thrombospondin motifs 4
Molecular Weight
Mass (kDA):
90.197 kDA
Genomic Context
| Human | |
|---|---|
| Location: | 1q23.3 |
| Sequence: | 1; NC_000001.11 (161184302..161202339, complement) |
Tissue Specificity
Expressed in brain, lung and heart (PubMed:23897278). Expressed at very low level in placenta and skeletal muscles (PubMed:23897278). Isoform 2: Detected in osteoarthritic synovium (PubMed:16723216, PubMed:23897278).
Subcellular Localizations
Secreted, extracellular space, extracellular matrix.
Diseases
- Degenerative Polyarthritis
- Arthritis
- Neoplasms
- Abnormal Degeneration
- Chondrosarcoma
- Inflammation
- Tumor Angiogenesis
- Malignant Neoplasms
- Rheumatoid Arthritis
- Malignant Paraganglionic Neoplasm
- Infarction
- Atherosclerosis
- Glioma
Pathways
- Proteolysis
- Angiogenesis
- Pathogenesis
- Localization
- Cell Death
- Cell Migration
- Reverse Transcription
- Cell Proliferation
- Ovulation
- Rna Interference
- Cell Adhesion
- Protein Catabolic Process
- Aging
PTMs
- Cleavage
- Phosphorylation
Research Areas
- Cancer
- GPCR
- Neuroscience
- Vision
For details, visit:
bosterbio.com/bosterbio-gene-info-cards/ADAMTS4
bosterbio.com/bosterbio-gene-info-cards/ADAMTS4
References
PMID: 10356395 by Tortorella M.D., et al. Purification and cloning of aggrecanase-1: a member of the ADAMTS family of proteins.
PMID: 16723216 by Wainwright S.D., et al. An alternative spliced transcript of ADAMTS4 is present in human synovium from OA patients.
4 Publications of Boster ADAMTS4 Antibodies & ELISA Kits
- PubMed ID: 10.4049/jimmunol.1501165, Galectin-1 Couples Glycobiology to Inflammation in Osteoarthritis through the Ac...
- PubMed ID: 10.1038/srep39112, Galectin-3 Induces a Pro-degradative/inflammatory Gene Signature in Human Chondr...
- PubMed ID: 10.1016/j.intimp.2020.106657, Sodium butyrate protects against oxidative stress in human nucleus pulposus cell...
- PubMed ID: 23990941, Electrospun Poly(L-lactide)/Poly(?-caprolactone) Blend Nanofibrous Scaffold: Cha...
*More publications can be found for each product on its corresponding product page