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Antagonizes TNF-alpha by negatively regulating its expression in a variety of tissues such as liver and macrophages, and by counteracting its effects. Inhibits endothelial NF-kappa-B signaling through a cAMP-dependent pathway.
|Sequence:||3; NC_000003.12 (186842710..186858463)|
Synthesized exclusively by adipocytes and secreted into plasma.
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