Ankyrin-1 Antibodies

Ankyrin-1 (ANK1)

Attaches integral membrane proteins to cytoskeletal components; binds to the erythrocyte membrane protein band 4.2, to Na-K ATPase, to the lymphocyte membrane protein GP85, and to the cytoskeletal proteins fodrin, tubulin, vimentin and desmin.

Erythrocyte ankyrins also link spectrin (beta chain) to the cytoplasmic domain of the erythrocytes anion exchange protein; they retain most or all these binding functions. .

Gene Information

Human
Gene Name:	ANK1
Uniprot:	P16157
Entrez:	286

Family

Belongs to:
No superfamily

Alternative Names

ANK; ANK-1; ankyrin 1, erythrocytic; ankyrin-1; ankyrin-R; Erythrocyte ankyrin; SPH1; SPH2

Molecular Weight

Mass (kDA):
206.265 kDA

Genomic Context

Human
Location:	8p11.21
Sequence:	8; NC_000008.11 (41653225..41896741, complement)

Tissue Specificity

Isoform Mu17, isoform Mu18, isoform Mu19 and isoform Mu20 are expressed in skeletal muscle. Isoform Br21 is expressed in brain.

Subcellular Localizations

[Isoform Er1]: Cytoplasm, cytoskeleton. Probably the other erythrocyte (Er) isoforms, are located near the surface of erythrocytic plasma membrane.; [Isoform Mu17]: Membrane. Cytoplasm, myofibril, sarcomere, M line. Colocalizes with OBSCN isoform 3/obscurin at the M line in differentiated skeletal muscle cells.; [Isoform Mu18]: Sarcoplasmic reticulum.; [Isoform Mu19]: Sarcoplasmic reticulum.; [Isoform Mu20]: Sarcoplasmic reticulum.

Diseases

• Hereditary Spherocytosis
• Anemia
• Anemia, Hemolytic, Congenital
• Anemia, Hemolytic
• Neoplasms
• Malignant Neoplasms
• Carcinoma
• Elliptocytosis, Hereditary
• Werner Syndrome
• Premature Aging Syndrome
• Dysequilibrium Syndrome
• Myopathy
• Pain

• Diabetes Mellitus
• Icterus
• Erythroblastosis
• Hydrops Fetalis
• Hypoxia
• Malaria
• Hereditary Stomatocytosis

Pathways

• Localization
• Transport
• Aging
• Translation
• Methylation
• Gene Silencing
• Cell Cycle
• Dna Methylation
• Cell Adhesion
• Immune Response
• Hypersensitivity
• Nuclear Export
• Reverse Transcription

• Sensitization
• Ammonium Transport
• Cell-cell Adhesion
• Enucleation
• Histone Deacetylation
• Intracellular Transport
• Secretory Pathway

PTMs

• Methylation

• Hydroxylation

• Acetylation

For details, visit:
bosterbio.com/bosterbio-gene-info-cards/ANK1

Boster Bio ANK1 Antibody - Best Uses Of The ANK1 Marker

When researching anti-ANK1 antibodies, many people get confused. Thankfully, this article will explain the best way to use Boster Bio's ANK1 Antibody. If you're new to protein immunoassays, there are many ways to use it and get the best results. The process is simple, but there are a few things to keep in mind when you're using this protein.

Boster Bio Anti-KHDRBS2 Antibody

The Boster Bio Anti-KHDRBS2-Antibody reacts with human, mouse and rat samples. It is non-hazardous, can be stored at 4°C and has a shelf life of one month. It contains 5mg BSA and peptides. For best results, use blocking peptides, which are available for purchase.

Boster Bio Anti-Bax (S4) Antibody

The Boster Bio Anti-Bax (six-transmembrane protein) Antibody is manufactured in a validated process. The antibody recognizes the human ANK1 marker. The antibody is supplied in PBS containing 0.09% sodium azide and is purified through dialysis and a protein G column. The antibody is available in several different sizes, so the amount required for a specific assay is highly variable.

The Anti-Bax Antibody has been validated in ELISA, WB, and immunohistochemistry. It reacts with Human, Mouse, and Rat. It has been used to investigate a number of diseases. This antibody is non-hazardous and is available in a corresponding Boster Bio kit. The Anti-Bax (S4) Antibody is validated in WB, IHC, Immunofluorescence, and ELISA.

Boster Bio Anti-KHDRBS2

The Boster Bio Anti-KHDRBS2, also known as B-KHDRBS2, is an antibody that recognizes the ANK1 marker. It is a homodimer with 3 chains, which was formerly known as laminin beta-2 (LAMA2). The gene contains 260,000 base pairs and 64 exons. The protein is related to merosin, a basement membrane-associated protein. Both proteins play a key role in striated muscle disease.