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- Table of Contents
Ankyrin-1 Antibodies
AND ANK1 ELISA kits, Ankyrin-1 Proteins
Many biological assays use antibodies to detect Ankyrin-1, such as Western Blot (WB), ELISA, Flow Cytometry, Immunocytochemistry (IHC). These antibodies can be polyclonal or monoclonal, and react with Ankyrin-1 in Human, Mouse, Rat, and many other animal samples. Boster Bio use mainly mouse and rabbit to develop Ankyrin-1 antibodies...
Designing a Western blot for Ankyrin-1? The guide has the expected band size, antibodies backed by real blot images, the controls to run alongside, and protocols taken from published papers.
Open the ANK1 Western Blot GuideANK1 Infographic by Boster Bio
All ANK1 Products
Product
Figures
Specificity
Applications
Price
Human
Flow Cytometry, WB
$370
Cat # M02716-1
100 μg/vial
Cat # M02716-1
100 μg/vial
Human
WB
$370
Cat # M02716
100 μg/vial
Cat # M02716
100 μg/vial
Human, Mouse, Rat
ELISA, Flow Cytometry, IF, IHC, ICC, WB
$370
Cat # A02716-1
100 μg/vial
Cat # A02716-1
100 μg/vial
ANK1 Overview
Facts about Ankyrin-1.
Ankyrin-1 (ANK1)
Attaches integral membrane proteins to cytoskeletal components; binds to the erythrocyte membrane protein band 4.2, to Na-K ATPase, to the lymphocyte membrane protein GP85, and to the cytoskeletal proteins fodrin, tubulin, vimentin and desmin.
Erythrocyte ankyrins also link spectrin (beta chain) to the cytoplasmic domain of the erythrocytes anion exchange protein; they retain most or all these binding functions. .
Gene Information
| Human | |
|---|---|
| Gene Name: | ANK1 |
| Uniprot: | P16157 |
| Entrez: | 286 |
Family
| Belongs to: |
|---|
| No superfamily |
Alternative Names
ANK; ANK-1; ankyrin 1, erythrocytic; ankyrin-1; ankyrin-R; Erythrocyte ankyrin; SPH1; SPH2
Molecular Weight
Mass (kDA):
206.265 kDA
Genomic Context
| Human | |
|---|---|
| Location: | 8p11.21 |
| Sequence: | 8; NC_000008.11 (41653225..41896741, complement) |
Tissue Specificity
Isoform Mu17, isoform Mu18, isoform Mu19 and isoform Mu20 are expressed in skeletal muscle. Isoform Br21 is expressed in brain.
Subcellular Localizations
[Isoform Er1]: Cytoplasm, cytoskeleton. Probably the other erythrocyte (Er) isoforms, are located near the surface of erythrocytic plasma membrane.; [Isoform Mu17]: Membrane. Cytoplasm, myofibril, sarcomere, M line. Colocalizes with OBSCN isoform 3/obscurin at the M line in differentiated skeletal muscle cells.; [Isoform Mu18]: Sarcoplasmic reticulum.; [Isoform Mu19]: Sarcoplasmic reticulum.; [Isoform Mu20]: Sarcoplasmic reticulum.
Diseases
- Hereditary Spherocytosis
- Anemia
- Anemia, Hemolytic, Congenital
- Anemia, Hemolytic
- Neoplasms
- Malignant Neoplasms
- Carcinoma
- Elliptocytosis, Hereditary
- Werner Syndrome
- Premature Aging Syndrome
- Dysequilibrium Syndrome
- Myopathy
- Pain
Pathways
- Localization
- Transport
- Aging
- Translation
- Methylation
- Gene Silencing
- Cell Cycle
- Dna Methylation
- Cell Adhesion
- Immune Response
- Hypersensitivity
- Nuclear Export
- Reverse Transcription
PTMs
- Methylation
For details, visit:
bosterbio.com/bosterbio-gene-info-cards/ANK1
bosterbio.com/bosterbio-gene-info-cards/ANK1
References
PMID: 2137557 by Lux S.E., et al. Analysis of cDNA for human erythrocyte ankyrin indicates a repeated structure with homology to tissue-differentiation and cell-cycle control proteins.
PMID: 1689849 by Lambert S., et al. cDNA sequence for human erythrocyte ankyrin.