APBA3 Antibodies

Amyloid-beta A4 precursor protein-binding family A member 3 (APBA3)

May modulate processing of the amyloid-beta precursor protein (APP) and hence creation of APP-beta. May enhance the activity of HIF1A in macrophages by inhibiting the activity of HIF1AN.

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Gene Information

Human
Gene Name:	APBA3
Uniprot:	O96018
Entrez:	9546

Family

Belongs to:
No superfamily

Alternative Names

Adapter protein X11gamma; amyloid beta (A4) precursor protein-binding, family A, member 3 (X11-like 2); amyloid beta (A4) precursor protein-binding, family A, member 3; APBA3; MGC:15815; MINT3; mint-3; Neuronal Munc18-1-interacting protein 3; Neuron-specific X11L2 protein; phosphotyrosine-binding/-interacting domain (PTB)-bearing protein; X11L2; X11L2amyloid beta A4 precursor protein-binding family A member 3; X11-like 2 protein

Molecular Weight

Mass (kDA):
61.454 kDA

Genomic Context

Human
Location:	19p13.3
Sequence:	19; NC_000019.10 (3750772..3761696, complement)

Tissue Specificity

Expressed in all tissues examined with lower levels in brain and testis.

Subcellular Localizations

Cytoplasm, perinuclear region.

Diseases

• Alzheimer's Disease
• Malignant Neoplasms
• Neoplasms
• Microsatellite Instability
• Rectal Neoplasms
• Colonic Neoplasms
• Malignant Tumor Of Colon
• Hypoxia
• Carcinoma
• Braf Np_004324.2:p.v600e
• Neuroblastoma
• Cell Transformation, Neoplastic
• Rectal Carcinoma

• Adenoma
• Intraepithelial Neoplasia
• Polyps
• Duodenal Neoplasms
• Myeloid Leukemia, Chronic
• Hypokinesia
• Dysplasia

Interacting Proteins

• Azi2
• HIF1AN
• NECAB3
• TANK
• TBKBP1

Pathways

• Localization
• Methylation
• Glycolysis
• Transport
• Secretory Pathway
• Endocytosis
• Oxidative Phosphorylation
• Pathogenesis
• Secretion
• Dna Methylation
• Vesicle Fusion

• Nuclear Export
• Cytokine Production
• Synaptic Vesicle Fusion
• Cell Growth
• Rna Interference

PTMs

• Methylation
• Cleavage

• Ribosylation
• Phosphorylation

For details, visit:
bosterbio.com/bosterbio-gene-info-cards/APBA3

Best Uses Of The APBA3 Marker

The APBA3Marker has a high level of discriminative power, and was captured by anti-DDK affinity columns. This article will discuss the best uses of this marker and how it can be used to detect the macrosialin CD68. The APBA3 identifies a machine-learning algorithm. It captures, for example, the CD68 macrosialin protein and can be used in detection.

It was captured in an anti-DDK affinity Column

The Thermo Scientific Pierce Anti-DYKDDDDK Affinity Resin provides a fast and convenient immunoprecipitation method. The DYKDDDDK or FLAG sequence is recognized with a high-affinity rat monoclonal immunoglobulin that is covalently linked to a porous yet rigid UltraLink Biosupport. It is ideal to use in medium-pressure or fast flow techniques.

The anti DDK affinity column captures boster antibody in a similar way to conventional chromatography steps. The Amsphere A3 chemical is flexible enough to capture different fragments of antibody. It can capture monoclonal antibodies and constructs that contain the VH3domain. This is a great technique for industrial production.

It is used to detect macrosialin CD68

The human and mouse macrosialin-CD68 proteins are closely related. Both LAMPs share a mucinlike domain. Like other LAMPs, CD68 is a receptor for phosphatidylserine and oxLDL. It also binds to apoptotic tissues and the malariasporozoite, in a liver infection. Its role as an scavenger receptor, despite being very similar to LAMPs is still not known.

Anti-human CD68 antibodies have been developed for use in immunological applications. Bio-Rad supplies a large variety of monoclonal antibodies for the detection and quantification of CD68 in human or mouse samples. The Anti-Rat CD68 clone ED1 rat macrophage markers is widely used. It recognizes the rat homolog to human CD68.

The APBA3 genes are responsible for the detection of macrosialinCD68. This gene is highly expressing in osteoclasts. It is inconsistently expressed in lymphoid and tumor cells as well as non-hematopoid tissues. This gene is important for many immune functions and has already been identified as a potential marker for cancer.