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- Table of Contents
1 Citations
Facts about Aquaporin-5.
Required for TRPV4 activation by hypotonicity (PubMed:16571723). Together with TRPV4, controls regulatory volume decrease in salivary epithelial cells (PubMed:16571723).
Human | |
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Gene Name: | AQP5 |
Uniprot: | P55064 |
Entrez: | 362 |
Belongs to: |
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MIP/aquaporin (TC 1.A.8) family |
AQP-5; aquaporin 5; aquaporin-5
Mass (kDA):
28.292 kDA
Human | |
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Location: | 12q13.12 |
Sequence: | 12; NC_000012.12 (49961855..49965682) |
Apical cell membrane; Multi-pass membrane protein. Cell membrane; Multi-pass membrane protein. Cytoplasmic vesicle membrane; Multi-pass membrane protein. Hypotonicity increases location at the cell membrane. Phosphorylation decreases location at the cell membrane.
If you're looking to find the most effective Boster Bio Anti-Aquaporin 5/AQP5 Antibody Picoband(tm) to conduct your research, then read on! This article will go over some of the most well-known uses for this marker. This product works well in the following applications:
The Boster Bio Anti-Aquaporin antibody in 5/AQP5Antibody PicoBand(tm), a monoclonal antibody, was specifically designed to detect AQP5 protein. Boster antibodies have been validated and tested for a variety of applications such as WB, Immunohistochemistry and ELISA. Since 1995 the company has been providing high-affinity monoclonal antibodies to research communities across the globe.
AQP5 is an aquaporin-encoded protein. Aquaporins are membranes that are water-selective. AQP4 is the most dominant water channel in the brain and is involved with water homeostasis. The gene was identified on chromosome 18q11.2-q12.1. Its position was determined through interspecific backcross analysis. Frigeri et al. have identified the expression of AQP4 in mammalian skeletal muscles.
Western Blotting was used to confirm the Boster Bio Anti -AquaporIn 5/AQP5 Antibody PicoBand(tm). It was conducted on both negative and positive samples. These samples demonstrate excellent signal detecting ability. The anti-AQP5 antibody works with a variety of assays and can be used to detect the various forms of AQP5 protein.
The Boster Bio Anti-pNF-kb AQP5 marker is validated on various platforms and has been tested against positive and negative samples. The antibodies are tested to ensure high specificity and adsorption. Boster also offers product credits to scientists from all over the world who are the first to evaluate the products. This is a way that scientists are paid for their research.
The recombinant protein was created from E. coli and is part of the Picoband(tm) catalog. The Boster Bio Anti-pNF AQP5 marker interacts with Human, Mouse, Rat, and E. coli. The blocking peptide can be purchased separately. It is possible to perform a molecular imaging using this antibody, as is the Boster Bio Anti-pNF-kB markers are used for diagnostic purposes.
The analysis of the molecular makeup of colorectal cancer cells shows that AQP5 expression is not related to clinical outcomes. Additionally this marker has been suggested as a possible new biomarker for colorectal cancer. Its role in the epithelial-mesenchymal transition is unclear. AQP5 knockdown can reduce the EMT potential of cancer cells.
Molecular analysis can help detect inflammation-related disorders by detecting the protein's presence in an eukaryotic cell. The Boster Bio Anti-pNFKB AQP5 marker permits researchers to determine the proteins that cause inflammation. The results can then be used to determine the root cause of inflammation in the patient. The Boster Bio Anti-pNF-kB QP5 marker is an excellent marker for studies in this area.
The knockdown of AQP5 inhibits the invasion and migration of cancerous cells in the colorectal area. Additionally, the knockdown of AQP5 inhibits the Wnt/b-catenin pathway and EMT-related genes. This study shows that AQP5 knockdown can effectively prevent cancer by regulating genes related to EMT. In addition, this marker could be used to improve patient outcomes by identifying the cause of cancer.
After the cells were fixed with Paraformaldehyde, 4% (BosterBio Pleasanton, CA, US) Sections were stained with nuclear antibodies. Images were later taken. The Boster Bio Anti-pNF-kB AQP5 marker is compatible with lung tissue RNA. It works by binding the VPAC1 receptor and promoting the expression of the cAMP. It also inhibits the NF-kB signaling pathway (p65).
AQP5 is one of the markers that are involved in the process of the release of water into the acini of the lungs. Based on the type of protein and where it is located, its expression level may differ. AQP5 is expressed more in the lung than its relatives, while AQP8 or 9 are more prevalent in the intestine. Lower levels of AQP5 in the intestine can be linked with lung edema as well as bronchial edema and could play a role in the pathogenesis of both diseases.
The AQPs are present in nearly every living thing including mice and humans. They regulate selective water flux across membranes. Singha and. and. discovered that AQP is associated with lung edema, and is responsible for regulating the water balance in lung. AQP1 gene knockout in mice caused an increase of tenfold in the alveolar capillary membranes. The knockouts of the gene in mice reduced the permeability and strength of the alveolar capillary membrane by fourteen to sixteen times. These changes are thought to alter the balance of the lung's water and lead to lung edema.
PMID: 8621489 by Lee M.D., et al. The human aquaporin-5 gene. Molecular characterization and chromosomal localization.
PMID: 16571723 by Liu X., et al. A role for AQP5 in activation of TRPV4 by hypotonicity: concerted involvement of AQP5 and TRPV4 in regulation of cell volume recovery.
*More publications can be found for each product on its corresponding product page