ASIC2 Antibodies

Acid-sensing ion channel 2 (ASIC2)

Cation channel with high affinity for sodium, which is gated by extracellular protons and inhibited by the diuretic amiloride. Also permeable for Li(+) and K(+).

Generates a biphasic current with a fast inactivating and a slow sustained phase. Heteromeric channel assembly seems to modulate.

Gene Information

Human
Gene Name:	ASIC2
Uniprot:	Q16515
Entrez:	40

Family

Belongs to:
amiloride-sensitive sodium channel (TC 1.A.6) family

Alternative Names

Acid-sensing ion channel 2; Amiloride-sensitive brain sodium channel; amiloride-sensitive cation channel 1, neuronal; ASIC2a; ASIC2Mammalian degenerin homolog; BNAC1; BNaC1ACCN; BNC1Amiloride-sensitive cation channel neuronal 1; degenerin; hBNaC1; MDEGBrain sodium channel 1; neuronal amiloride-sensitive cation channel 1

Molecular Weight

Mass (kDA):
57.709 kDA

Genomic Context

Human
Location:	17q11.2-q12
Sequence:	17; NC_000017.11 (33013087..34156806, complement)

Tissue Specificity

Brain and spinal cord. Isoform 1 is also detected in testis, liver, colon and ovary.

Subcellular Localizations

Cell membrane; Multi-pass membrane protein. Localized at the plasma membrane of neurons, in the soma and punctated peripheral processes.

Diseases

• Pain
• Nervousness
• Acidosis
• Inflammation
• Glioma
• Neoplasms
• Ischemia
• Nerve Degeneration
• Pathologic Vasoconstriction
• Hyperalgesia
• Stenosis
• Cardiovascular Diseases

• Hypertensive Disease
• Hypoxia
• Malignant Neoplasms
• Dysautonomia
• Mental Disorders
• Visceral Pain
• Neurodegenerative Disorders

Interacting Proteins

• PICK1

Pathways

• Localization
• Cell Migration
• Transport
• Muscle Cell Migration
• Smooth Muscle Cell Migration
• Synaptic Transmission
• Response To Ph
• Reflex
• Vasoconstriction
• Cell Death
• Pathogenesis
• Protein Phosphorylation
• Osteoclast Differentiation

• Proteolysis
• Vasculogenesis
• Swimming
• Chemotaxis
• Reverse Transcription
• Sensitization
• Translation

PTMs

• Cleavage

• Acetylation

• Methylation

For details, visit:
bosterbio.com/bosterbio-gene-info-cards/ASIC2

Best Uses Of The ASIC2 Marker

The ASIC2 marker has many important applications in histology and high-affinity prima antibodies. It also serves as a gene infographics marker. Boster Bio was started by Steven Boster (a scientist with the unusual name "he who converted science in the lavatory"). His company grew and he developed products for immunohistochemistry, (IHC), as well as hundreds of primary antibodies. Boster was China's largest antibody catalog by the end of the 1990s. Boster Bio developed a proprietary ELISA platform called PicoKine(tm) that uses trade secrets to deliver high-sensitivity ELISA kits for a range of applications.

Primary antibodies with high-affinity

Boster Bio has high-quality and high-affinity primary antibody products. The company offers more than 12,000 validated antibodies for WB, Flow and IHC. These antibodies are tested against more than 250 samples, which includes recombinant proteins as well as untransfected cells. To ensure consistency in quality and reproducibility, each antibody has been produced using state of-the-art equipment.

Boster Bio is unique in that it produces rabbit monoclonal antibody technologies. While there are many companies producing antibodies based on this technology, Boster Bio is one of the few companies to produce mAbs based on rabbit monoclonal antibody technology. These antibodies are produced using proprietary plasma-cell technology. The technology screens individual cells treated using proprietary chemistry to stop B cells from secreting antibody while retaining them on cell walls. The antigens can then be incubated together with plasma cells and splenocytes to create high affinity antibodies.

Primary antibodies are immunoglobulins that only bind to a target antigen. Primary antibodies are classified according their specificity and affinity. These are the strength or non-covalent bonds they form. A higher affinity indicates better specificity. Good antibodies are useful for detection and purification as well as measurement. These antibodies are available at a variety of concentrations and sizes. The BosterBio high-affinity prima antibodies are a versatile tool for research or development.

ELISA kits from Boster Bio are a powerful and versatile tool for detection of hormones, small molecules, and oxidative stress. They can also detect cytokines, such as IL-6 or IL-8. Unlike conventional ELISA kits, Boster Bio Picokine ELISA kit is highly sensitive, with a sensitivity equivalent to 15 percent. The company also boasts a vast manufacturing experience and exclusive methods.

MBP-Linker-scFv was tested for its specificity against IFN-g. It was found to be highly specific against IFN–g and cross-reactive at less than 1%. ELISA can also measure the affinities for antibodies to other substances. They are highly specific for IFNg and highly purified.

Gene infographics

The Gene infographics for Boster Bio provide basic information on each gene. The graphics cover all gene types in human and mouse. The Boster Bio website is also home to several other helpful resources, including gene cloning tools, gene sequences, and reference materials. Genes are essential in the development of many medical treatments.

Histology

Immunohistochemistry, which is a method of staining cells to detect antigens or haptens, is an important part histology. Boster Bio's antibody are sensitive enough that they can detect these antigens or haptens from a wide range of samples including cancer cells, neural tissue, and even eukaryotic cell. The company's expertise is in optimizing these antibodies and dilutions. Additionally, they provide Multiplex Immunohistochemistry services to allow detection of multiple targets with a single assay.

Boster Bio, a world-class company, offers high-specificity ELISA Kits for molecular Biology. Boster Bio offers a range of IHC and WB/IHC immunohistochemical kit, as well as a proprietary ELISA platform called PicoKine(tm). These high-sensitivity ELISA tests have been validated against multiple biologically relevant matrices. Visit the company's site for more information.

Histology in Boster bio is also known by the Chinese name Xiang Yue Ji Shu. This type of training is used by many Chinese researchers. One of the most common is the use of ELISA, which is an immunoassay. The other major application is to determine the cellular composition of tissues in the body. Then, a corresponding culture of cells is created using a protein digesting technique known as ELISA.