ATF1 Antibodies

Cyclic AMP-dependent transcription factor ATF-1 (ATF1)

This protein binds the cAMP response element (CRE) (consensus: 5'-GTGACGT[AC][AG]-3'), a sequence present in many viral and cellular promoters. Binds to the Tax-responsive element (TRE) of HTLV-I.

Mediates PKA-induced stimulation of CRE-reporter genes. Represses the expression of FTH1 along with other antioxidant detoxification genes.

Gene Information

Human
Gene Name:	ATF1
Uniprot:	P18846
Entrez:	466

Family

Belongs to:
bZIP family

Alternative Names

activating transcription factor 1FUS/ATF-1; ATF1; cAMP-dependent transcription factor ATF-1; EWS-ATF1; Protein TREB36; TREB36; TREB36cyclic AMP-dependent transcription factor ATF-1

Molecular Weight

Mass (kDA):
29.233 kDA

Genomic Context

Human
Location:	12q13.12
Sequence:	12; NC_000012.12 (50763682..50821162)

Subcellular Localizations

Nucleus.

Diseases

• Neoplasms
• Sarcoma
• Sarcoma, Clear Cell
• Melanoma
• Malignant Neoplasms
• Malignant Paraganglionic Neoplasm
• Soft Tissue Neoplasms
• Ewings Sarcoma-primitive Neuroectodermal Tumor (pnet)
• Physiological Stress
• Chromosomal Translocation
• Neoplasm Metastasis
• Leukemia

• Histiocytoma
• Histiocytoma, Benign Fibrous
• Angiomatoid Fibrous Histiocytoma
• Carcinoma
• Malignant Fibrous Histiocytoma
• Feline Urological Syndrome
• Cell Transformation, Neoplastic

Interacting Proteins

• CREB1
• ESR1
• JUN
• NFATC1
• NFIL3

Pathways

• Cell Cycle
• Fermentation
• Localization
• Translation
• Response To Oxidative Stress
• Meiosis
• Methylation
• Mating
• Cell Proliferation
• Hypersensitivity
• Cell Death
• Mapk Cascade
• Heterochromatin Assembly

• Gene Silencing
• Response To Stress
• Pigmentation
• Reverse Transcription
• Conjugation
• Rna Interference
• Cell Activation

PTMs

• Phosphorylation
• Acetylation
• Methylation
• Deacetylation
• Dephosphorylation

• Oxidation
• Sumoylation
• Biotinylation
• Cleavage
• Ubiquitination

Research Areas

• Phospho-Specific

For details, visit:
bosterbio.com/bosterbio-gene-info-cards/ATF1

Best Uses Of The ATF1 Marker

You've come to the right place if are in search of an antibody that has a high affinity for ATF1 protein. We will cover the Boster Bio Anti-Caveolin-1 Antibody and its gene infographics. Additionally, you will be informed about Boster's high-affinity primary antibodies as well as gene infographics. So what are you wasting time for? Get your hands on these high-affinity antibodies!

Boster Bio Anti-Caveolin-1/CAV1 Antibody

The Boster Bio Anti Caveolin-1 Antibody Picoband Antibody has a molecular weight of 12C7 and reacts with the Caveolin-1 protein found in human as well as mouse and rats. This antibody is also compatible with blocking peptides which are available to purchase. The cost of blocking peptides is contingent on the length and sensitivity of the immunogen.

Boster Bio Anti-ATF1 Marker

Boster Bio has the perfect product for you if your looking for an antibody that detects the expression of ATF1. With catalog number A01600-1, this antibody is an reagent with high-affinity that reacts with Human, Mouse, Rat and Flies. This product has been extensively tested to determine its effectiveness in Western Blotting, Immunohistochemistry, and other applications.

Boster's high affinity primary antibodies

Advanced Targeting Systems offers neuroendocrine and neuroscience antibody production. These antibodies are highly specific and recognize multiple epitopes of one antigen. Monoclonal antibodies are stable in various conditions, including high pH and high salt concentrations. They are also cheap and can endure washing. High-affinity primary antibodies are constructed from DNA sequences. This makes them highly specific to a particular peptide epitope.

Monoclonal antibodies recognize a variety of epitopes that are part of the same protein. They are also extremely specific for nonserial segments which can be useful for cell type analysis. Monoclonal antibody can be used in a variety of ways, including cell-type analysis. Although high-affinity monoclonal antibody may be sold under different catalog numbers however, the ATF1 marker is the identical for all.

The EWSR1 and ATF1 gene fusions encode the EWSR1–ATF1 cancer-causing oncoprotein. Clear cell sarcoma can be described as the most frequent cancer caused by this gene fusion. The ATF1 gene fusion is a multifaceted and highly variable molecule that could cause a range of clinical issues.

Preincubation can be used to control antibody specificity because monotype antibodies are not very receptive to antibodies. The monotypic antibody is in equilibrium with the immunogen for extended time periods of incubation when there is a high excess of the molar. This preincubation provides convincing proof of the specificity of the antibody, however, it does not rule out the possibility of immune-mimetic epitopes in the target tissue.

In addition to manufacturing monoclonal antibodies. The company also produces polyclonal antibody-based immunoassays. The company provides monoclonal antibodies as well as chimeric antigens as well as custom peptides. Abcam also provides research services that help develop multi-assays as well as antibody conjugates. It also offers antibody conjugates. Alpha Diagnostic International also offers a variety of antibodies.