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- Table of Contents
BAD Antibodies
AND BAD ELISA kits, BAD Proteins
Many biological assays use antibodies to detect BAD, such as Western Blot (WB), ELISA, Flow Cytometry, Immunocytochemistry (IHC). These antibodies can be polyclonal or monoclonal, and react with BAD in Human, Mouse, Rat, and many other animal samples. Boster Bio use mainly mouse and rabbit to develop BAD antibodies...
Designing a Western blot for BAD? The guide has the expected band size, antibodies backed by real blot images, the controls to run alongside, and protocols taken from published papers.
Open the BAD Western Blot GuideDesigning an IHC experiment for BAD? The guide has the expected staining pattern, antigen retrieval and fixation, antibodies backed by real IHC images, the tissue controls to run alongside, and protocols taken from published papers.
Open the BAD IHC GuideBAD Infographic by Boster Bio
All BAD Products
Product
Figures
Specificity
Applications
Price
Anti-Bad Rabbit Monoclonal Antibody
12 Citations
Human, Mouse, Rat
Flow Cytometry, IP, IF, IHC, ICC, WB
$370
Cat # M03520
100 μl
Cat # M03520
100 μl
Human, Mouse, Rat
ELISA, IP, IF, IHC, WB
$146
Cat # M03520-1
20μL, 40μL, 100μL, 200μL
Cat # M03520-1
20μL, 40μL, 100μL, 200μL
Human, Mouse, Rat
ELISA
$540
Cat # EKC2359
1 kit, containing two 96-well plates and all necessary reagents
Cat # EKC2359
1 kit, containing two 96-well plates and all necessary reagents
Human, Mouse, Rat
ELISA
$540
Cat # EKC2358
1 kit, containing two 96-well plates and all necessary reagents
Cat # EKC2358
1 kit, containing two 96-well plates and all necessary reagents
Human, Mouse, Rat
ELISA
$540
Cat # EKC2357
1 kit, containing two 96-well plates and all necessary reagents
Cat # EKC2357
1 kit, containing two 96-well plates and all necessary reagents
Human, Mouse, Rat
ELISA
$540
Cat # EKC2216
1 kit, containing two 96-well plates and all necessary reagents
Cat # EKC2216
1 kit, containing two 96-well plates and all necessary reagents
Human, Mouse, Rat
ELISA
$540
Cat # EKC2215
1 kit, containing two 96-well plates and all necessary reagents
Cat # EKC2215
1 kit, containing two 96-well plates and all necessary reagents
Human, Mouse, Rat
ELISA
$480
Cat # EKC1051
1 kit, containing one 96-well plate and all necessary reagents
Cat # EKC1051
1 kit, containing one 96-well plate and all necessary reagents
BAD Overview
Facts about Bcl2-associated agonist of cell death.
Bcl2-associated agonist of cell death (BAD)
Promotes cell death. Successfully competes for the binding to Bcl-X(L), Bcl-2 and Bcl-W, thereby affecting the level of heterodimerization of these proteins with BAX.
Can reverse the death repressor activity of Bcl-X(L), but not that of Bcl-2 (By similarity). Appears to act as a link between growth factor receptor signaling and the apoptotic pathways.
Gene Information
| Human | |
|---|---|
| Gene Name: | BAD |
| Uniprot: | Q92934 |
| Entrez: | 572 |
Family
| Belongs to: |
|---|
| Bcl-2 family |
Alternative Names
Bad; BBC2; BBC6; bcl2 antagonist of cell death; BCL2-antagonist of cell death protein; BCL2-associated agonist of cell death; Bcl-2-binding component 6; BCL2-binding component 6; BCL2-binding protein; BCL2L8; Bcl2-L-8; BCL2L8bcl2-L-8; Bcl-2-like protein 8; BCL-X/BCL-2 binding protein; Bcl-XL/Bcl-2-associated death promoter
Molecular Weight
Mass (kDA):
18.392 kDA
Genomic Context
| Human | |
|---|---|
| Location: | 11q13.1 |
| Sequence: | 11; NC_000011.10 (64269828..64284704, complement) |
Tissue Specificity
Expressed in a wide variety of tissues.
Subcellular Localizations
Mitochondrion outer membrane. Cytoplasm. Colocalizes with HIF3A in the cytoplasm (By similarity). Upon phosphorylation, locates to the cytoplasm.
Diseases
- Malignant Neoplasms
- Neoplasms
- Carcinoma
- Leukemia
- Malignant Paraganglionic Neoplasm
- Malignant Neoplasm Of Prostate
- Ischemia
- Malignant Neoplasm Of Breast
- Prostatic Neoplasms
- Cell Transformation, Neoplastic
- Mammary Neoplasms
- Adenocarcinoma
Interacting Proteins
- BCL2
- BCL2L1
- BCL2L11
- BCL2L2
- BNIP3L
- MAPK8
- RAF1
- SFN
- YWHAH
- YWHAZ
Pathways
- Cell Death
- Cell Cycle
- Cell Proliferation
- Cell Growth
- Induction Of Apoptosis
- Pathogenesis
- Programmed Cell Death
- Localization
- Secretion
- Cell Cycle Arrest
- Rna Interference
- Neuroprotection
- Mitochondrial Translocation
PTMs
- Phosphorylation
- Cleavage
- Dephosphorylation
- Methylation
- Reduction
- Acetylation
- Deamination
- Ubiquitination
- Oxidation
- Prenylation
Research Areas
- Apoptosis
- Cancer
- Tumor Suppressors
For details, visit:
bosterbio.com/bosterbio-gene-info-cards/BAD
bosterbio.com/bosterbio-gene-info-cards/BAD
References
PMID: 8929532 by Wang H.-G., et al. Bcl-2 targets the protein kinase Raf-1 to mitochondria.
PMID: 9388232 by Ottilie S., et al. Dimerization properties of human BAD. Identification of a BH-3 domain and analysis of its binding to mutant BCL-2 and BCL-XL proteins.
3 Publications of Boster BAD Antibodies & ELISA Kits
- PubMed ID: 33727850, Xie H,Wang H,Wu Q,Peng J,Huang H,Wang Y,Huang M,Jiang W,Yang Y,Zhang X,Zhang J,Z...
- PubMed ID: 33382670, Chen H,Sheng H,Zhao Y,Zhu G.Piperine Inhibits Cell Proliferation and Induces Apo...
- PubMed ID: 25516716, Wang Q, Xu Y, Zhou W, Zhong L, Wen Z, Yu H, Chen S, Shen J, Chen H, She Q, Jiang...
*More publications can be found for each product on its corresponding product page