Pre-mRNA-splicing factor SPF27 (BCAS2)

Part of the PRP19-CDC5L complex that forms an integral component of the spliceosome and is required for activating pre-mRNA splicing. May have a scaffolding role in the spliceosome assembly as it contacts all other components of the core complex.

The PRP19-CDC5L complex may also play a role in the response to DNA damage (DDR). .