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CD2-associated protein Antibodies
AND Cd2ap ELISA kits, CD2-associated protein Proteins
Many biological assays use antibodies to detect CD2-associated protein, such as Western Blot (WB), ELISA, Flow Cytometry, Immunocytochemistry (IHC). These antibodies can be polyclonal or monoclonal, and react with CD2-associated protein in Human, Mouse, Rat, and many other animal samples. Boster Bio use mainly mouse and rabbit to develop CD2-associated protein antibodies...
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Cd2ap Infographic by Boster Bio
All Cd2ap Products
Product
Figures
Specificity
Applications
Price
Anti-CD2AP Antibody Picoband®
1 Citations
Human, Mouse, Rat
ELISA, Flow Cytometry, IP, IF, IHC, ICC, WB
$370
Cat # A01756-2
100 μg/vial
Cat # A01756-2
100 μg/vial
Human, Mouse, Rat
Flow Cytometry, IF, IHC, ICC, WB
$370
Cat # M01756
100 μg/vial
Cat # M01756
100 μg/vial
Cd2ap Overview
Facts about CD2-associated protein.
CD2-associated protein (Cd2ap)
Seems to act as an adapter protein between membrane proteins and the actin cytoskeleton (By similarity). In cooperation with CBLC, modulates the speed of RET turnover and may act as regulatory checkpoint that restricts the potency of GDNF on neuronal survival.
May play a role in receptor clustering and cytoskeletal polarity at the junction between T-cell and antigen-presenting cell (PubMed:9741631). May anchor the podocyte slit diaphragm to the actin cytoskeleton in renal glomerolus (PubMed:10514378).
Gene Information
| Mouse | |
|---|---|
| Gene Name: | Cd2ap |
| Uniprot: | Q9JLQ0 |
| Entrez: | 12488 |
Family
| Belongs to: |
|---|
| No superfamily |
Alternative Names
adapter protein CMS; Cas ligand with multiple Src homology 3 (SH3) domains; CD2AP; CD2-associated protein; CMS; DKFZp586H0519
Molecular Weight
Mass (kDA):
70.45 kDA
Genomic Context
| Mouse | |
|---|---|
| Location: | 17|17 B3 |
| Sequence: | 17; |
Tissue Specificity
Expressed in podocytes (at protein level).
Diseases
- Proteinuria Of Undiagnosed Cause
- Kidney Diseases
- Nephrotic Syndrome
- Glomerulosclerosis (disorder)
- Focal Glomerulosclerosis
- Segmental Glomerulosclerosis
- Tissue Adhesions
- Kidney Failure
- Congenital Nephrotic Syndrome
- Renal Glomerular Disease
- Alzheimer's Disease
- Neoplasms
- Steroid-resistant Nephrotic Syndrome
Pathways
- Pathogenesis
- Localization
- Glomerular Filtration
- Endocytosis
- Cell Adhesion
- Cell Migration
- Transport
- Cytokinesis
- Cell Proliferation
- Excretion
- Clathrin-mediated Endocytosis
- Cell-cell Adhesion
- Cell Death
PTMs
- Phosphorylation
- Ubiquitination
For details, visit:
bosterbio.com/bosterbio-gene-info-cards/Cd2ap
bosterbio.com/bosterbio-gene-info-cards/Cd2ap
References
PMID: 9741631 by Dustin M.L., et al. A novel adaptor protein orchestrates receptor patterning and cytoskeletal polarity in T-cell contacts.
PMID: 10913159 by Lehtonen S., et al. In vivo interaction of the adapter protein CD2-associated protein with the type 2 polycystic kidney disease protein, polycystin-2.