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- Table of Contents
CHRM2 Antibodies
AND CHRM2 ELISA kits, CHRM2 Proteins
Many biological assays use antibodies to detect CHRM2, such as Western Blot (WB), ELISA, Flow Cytometry, Immunocytochemistry (IHC). These antibodies can be polyclonal or monoclonal, and react with CHRM2 in Human, Mouse, Rat, and many other animal samples. Boster Bio use mainly mouse and rabbit to develop CHRM2 antibodies...
Designing a Western blot for CHRM2? The guide has the expected band size, antibodies backed by real blot images, the controls to run alongside, and protocols taken from published papers.
Open the CHRM2 Western Blot GuideCHRM2 Infographic by Boster Bio
All CHRM2 Products
Product
Figures
Specificity
Applications
Price
Human, Mouse, Rat
IHC, WB
$370
Cat # PA1325-1
100 μg/vial
Cat # PA1325-1
100 μg/vial
Human, Mouse, Rat
WB
$370
Cat # A02733
100 μg/vial
Cat # A02733
100 μg/vial
CHRM2 Overview
Facts about Muscarinic acetylcholine receptor M2.
Muscarinic acetylcholine receptor M2 (CHRM2)
The muscarinic acetylcholine receptor mediates various cellular responses, including inhibition of adenylate cyclase, breakdown of phosphoinositides and modulation of potassium channels through the action of G proteins. Primary transducing effect is adenylate cyclase inhibition.
Signaling promotes phospholipase C activity, leading to the release of inositol trisphosphate (IP3); this then triggers calcium ion release to the cytosol. .
Gene Information
| Human | |
|---|---|
| Gene Name: | CHRM2 |
| Uniprot: | P08172 |
| Entrez: | 1129 |
Family
| Belongs to: |
|---|
| G-protein coupled receptor 1 family |
Alternative Names
7TM receptor; cholinergic receptor, muscarinic 2; CHRM2; FLJ43243; HM2; mAChR M2; MGC120006; MGC120007; muscarinic acetylcholine receptor M2; muscarinic M2 receptor
Molecular Weight
Mass (kDA):
51.715 kDA
Genomic Context
| Human | |
|---|---|
| Location: | 7q33 |
| Sequence: | 7; NC_000007.14 (136868637..137020255) |
Subcellular Localizations
Cell membrane; Multi-pass membrane protein. Cell junction, synapse, postsynaptic cell membrane; Multi-pass membrane protein. Phosphorylation in response to agonist binding promotes receptor internalization.
Diseases
- Depressive Disorder
- Mental Disorders
- Major Depressive Disorder
- Substance-related Disorders
- Dysequilibrium Syndrome
- Nervousness
- Social Disinhibition
- Personality Disorders
- Antisocial Personality Disorder
- Hereditary Diseases
- Nicotine Dependence
Pathways
- Cognition
- Pathogenesis
- Methylation
- System Development
- Prepulse Inhibition
- Nervous System Development
- Glycosylation
- Response To Nicotine
PTMs
Research Areas
- GPCR
- Neuroscience
For details, visit:
bosterbio.com/bosterbio-gene-info-cards/CHRM2
bosterbio.com/bosterbio-gene-info-cards/CHRM2
References
PMID: 3037705 by Bonner T.I., et al. Identification of a family of muscarinic acetylcholine receptor genes.
PMID: 3443095 by Peralta E.G., et al. Distinct primary structures, ligand-binding properties and tissue- specific expression of four human muscarinic acetylcholine receptors.