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- Table of Contents
Cannabinoid receptor 1 Antibodies
AND CNR1 ELISA kits, Cannabinoid receptor 1 Proteins
Many biological assays use antibodies to detect Cannabinoid receptor 1, such as Western Blot (WB), ELISA, Flow Cytometry, Immunocytochemistry (IHC). These antibodies can be polyclonal or monoclonal, and react with Cannabinoid receptor 1 in Human, Mouse, Rat, and many other animal samples. Boster Bio use mainly mouse and rabbit to develop Cannabinoid receptor 1 antibodies...
Designing a Western blot for Cannabinoid receptor 1? The guide has the expected band size, antibodies backed by real blot images, the controls to run alongside, and protocols taken from published papers.
Open the CNR1 Western Blot GuideCNR1 Infographic by Boster Bio
All CNR1 Products
Product
Figures
Specificity
Applications
Price
Human, Mouse, Rat
ELISA, Flow Cytometry, IHC, ICC, WB
$370
Cat # A01291-1
100 μg/vial
Cat # A01291-1
100 μg/vial
Anti-PKC theta/PRKCQ Antibody Picoband®
1 Citations
Human
ELISA, IHC, WB
$370
Cat # A01293-3
100 μg/vial
Cat # A01293-3
100 μg/vial
Human
ELISA, Flow Cytometry, Functional Assay, Kinetics
$486
Cat # M11640-1
100 μg
Cat # M11640-1
100 μg
Human, Mouse, Rat
ELISA, Flow Cytometry, WB
$370
Cat # A01291-2
100 µg/vial
Cat # A01291-2
100 µg/vial
Human
ELISA, Flow Cytometry, Functional Assay, Kinetics
$486
Cat # M11640
100 μg
Cat # M11640
100 μg
CNR1 Overview
Facts about Cannabinoid receptor 1.
Cannabinoid receptor 1 (CNR1)
G-protein coupled receptor for endogenous cannabinoids (eCBs), such as N-arachidonoylethanolamide (also known as anandamide or AEA) and 2-arachidonoylglycerol (2-AG), in addition to phytocannabinoids, such as delta(9)-tetrahydrocannabinol (THC) (PubMed:15620723, PubMed:27768894, PubMed:27851727). Mediates many cannabinoid-induced effects, acting, among others, on food intake, memory loss, gastrointestinal motility, catalepsy, ambulatory activity, anxiety, chronic pain.
Signaling typically involves reduction in cyclic AMP (PubMed:1718258, PubMed:21895628, PubMed:27768894). In the hypothalamus, might have a dual effect on mitochondrial respiration depending upon the agonist dose and possibly upon the cell type.
Gene Information
| Human | |
|---|---|
| Gene Name: | CNR1 |
| Uniprot: | P21554 |
| Entrez: | 1268 |
Family
| Belongs to: |
|---|
| G-protein coupled receptor 1 family |
Alternative Names
CANN6; CANN6CB1R; Cannabinoid R1; cannabinoid receptor 1 (brain); CannabinoidR1; CB1; CB1A; CB1K5; CB1R; CB-R; CB-RCB1cannabinoid receptor 1; central cannabinoid receptor; CNR; CNR1; SKR6R
Molecular Weight
Mass (kDA):
52.858 kDA
Genomic Context
| Human | |
|---|---|
| Location: | 6q15 |
| Sequence: | 6; NC_000006.12 (88139864..88167349, complement) |
Tissue Specificity
Widely expressed, with highest levels in fetal and adult brain. Expression levels of isoform 2 and isoform 3 are much lower than those of isoform 1.
Subcellular Localizations
Cell membrane; Multi-pass membrane protein. Membrane raft. Mitochondrion outer membrane. Cell projection, axon. Cell junction, synapse, presynapse. Unexpectedly, in the mitochondria, the C-terminus is located in the mitochondrial intermembrane space, a compartment topologically considered as extracellular. In canonical seven-transmembrane G-protein coupled receptors, the C-terminus is cytosolic (By similarity). Found on presynaptic axon terminals in some GABAergic neurons in the somatosensory cortex (By similarity).
Diseases
- Obesity
- Schizophrenia
- Depressive Disorder
- Nervousness
- Mental Disorders
- Substance-related Disorders
- Insulin Resistance
- Pain
- Diabetes Mellitus
- Anxiety Disorders
- Psychotic Disorders
Interacting Proteins
- ADORA2A
- ADRB2
- Arrb1
- CALN1
- GNAI1
Pathways
- Pathogenesis
- Localization
- Secretion
- Cell Adhesion
- Brain Development
- Transport
- Neurogenesis
- Sensitization
- Hormone Secretion
- Mitosis
- Cell Migration
- Cell Division
- Protein Import
PTMs
- Phosphorylation
Research Areas
- Cancer
- GPCR
- Neuroscience
- Neurotransmission
- Vision
For details, visit:
bosterbio.com/bosterbio-gene-info-cards/CNR1
bosterbio.com/bosterbio-gene-info-cards/CNR1
References
PMID: 2263478 by Gerard C., et al. Nucleotide sequence of a human cannabinoid receptor cDNA.
PMID: 1718258 by Gerard C., et al. Molecular cloning of a human cannabinoid receptor which is also expressed in testis.
1 Publications of Boster Cannabinoid receptor 1 Antibodies & ELISA Kits
- PubMed ID: 10.3389/fendo.2017.00268, The Roles of Anandamide, Fatty Acid Amide Hydrolase, and Leukemia Inhibitory Fac...
*More publications can be found for each product on its corresponding product page