Cannabinoid receptor 1 (CNR1)

G-protein coupled receptor for endogenous cannabinoids (eCBs), such as N-arachidonoylethanolamide (also known as anandamide or AEA) and 2-arachidonoylglycerol (2-AG), in addition to phytocannabinoids, such as delta(9)-tetrahydrocannabinol (THC) (PubMed:15620723, PubMed:27768894, PubMed:27851727). Mediates many cannabinoid-induced effects, acting, among others, on food intake, memory loss, gastrointestinal motility, catalepsy, ambulatory activity, anxiety, chronic pain.

Signaling typically involves reduction in cyclic AMP (PubMed:1718258, PubMed:21895628, PubMed:27768894). In the hypothalamus, might have a dual effect on mitochondrial respiration depending upon the agonist dose and possibly upon the cell type.