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- Table of Contents
CYBB Antibodies
AND CYBB ELISA kits, CYBB Proteins
Many biological assays use antibodies to detect CYBB, such as Western Blot (WB), ELISA, Flow Cytometry, Immunocytochemistry (IHC). These antibodies can be polyclonal or monoclonal, and react with CYBB in Human, Mouse, Rat, and many other animal samples. Boster Bio use mainly mouse and rabbit to develop CYBB antibodies...
Designing a Western blot for CYBB? The guide has the expected band size, antibodies backed by real blot images, the controls to run alongside, and protocols taken from published papers.
Open the CYBB Western Blot GuideCYBB Infographic by Boster Bio
All CYBB Products
Product
Figures
Specificity
Applications
Price
Anti-NOX2/gp91phox/CYBB Antibody Picoband®
25 Citations
Human, Mouse, Rat
IHC, WB
$370
Cat # PA1667
100 μg/vial
Cat # PA1667
100 μg/vial
Anti-NOX2/gp91phox/CYBB Antibody Picoband®
2 Citations
Human
ELISA, Flow Cytometry, IF, IHC, ICC, WB
$370
Cat # A00328-3
100 μg/vial
Cat # A00328-3
100 μg/vial
Anti-NOX2/gp91phox/CYBB Antibody Picoband®
3 Citations
Human, Mouse, Rat
ELISA, WB
$370
Cat # A00328
100 μg/vial
Cat # A00328
100 μg/vial
Anti-NOX2/gp91phox/CYBB Antibody Picoband®
1 Citations
Human
ELISA, Flow Cytometry, WB
$370
Cat # A00328-4
100 μg/vial
Cat # A00328-4
100 μg/vial
Human, Mouse, Rat
ELISA, IP, WB
$146
Cat # M00328-1
20μL, 40μL, 100μL, 200μL
Cat # M00328-1
20μL, 40μL, 100μL, 200μL
CYBB Overview
Facts about Cytochrome b-245 heavy chain.
Cytochrome b-245 heavy chain (CYBB)
Critical part of the membrane-bound oxidase of phagocytes that generates superoxide. It's the terminal part of a respiratory chain that transports single electrons from cytoplasmic NADPH throughout the plasma membrane to molecular oxygen on the exterior.
Also functions as a voltage-gated proton channel that mediates the H(+) currents of resting phagocytes. It participates in the regulation of cellular pH and is blocked by zinc.
Gene Information
| Human | |
|---|---|
| Gene Name: | CYBB |
| Uniprot: | P04839 |
| Entrez: | 1536 |
Family
| Belongs to: |
|---|
| No superfamily |
Alternative Names
CGD; CGD91-phox; Cytochrome b(558) subunit beta; cytochrome b-245 heavy chain; cytochrome b-245, beta polypeptide; Cytochrome b558 subunit beta; EC 1.6.3; GP91-1; GP91PHOX; GP91-PHOX; Heme-binding membrane glycoprotein gp91phox; NADPH oxidase 2; Neutrophil cytochrome b 91 kDa polypeptide; NOX2chronic granulomatous disease; p22 phagocyte B-cytochrome; p91-PHOX; Superoxide-generating NADPH oxidase heavy chain subunit
Molecular Weight
Mass (kDA):
65.336 kDA
Genomic Context
| Human | |
|---|---|
| Location: | Xp21.1-p11.4 |
| Sequence: | X; NC_000023.11 (37780059..37813461) |
Tissue Specificity
Detected in neutrophils (at protein level).
Subcellular Localizations
Cell membrane; Multi-pass membrane protein. As unassembled monomer may localize to the endoplasmic reticulum.
Diseases
- Granulomatous Disease, Chronic
- Granulomatous Disorder
- Inflammation
- Hypertensive Disease
- Infective Disorder
- Immunologic Deficiency Syndromes
- Ischemia
- Diabetes Mellitus
- Fibrosis
- Hypertrophy
- Atherosclerosis
- Hypoxia
Pathways
- Respiratory Burst
- Pathogenesis
- Cell Death
- Localization
- Inflammatory Response
- Phagocytosis
- Cell Proliferation
- Excretion
- Secretion
- Angiogenesis
- Transport
- Immune Response
- Vasoconstriction
PTMs
- Phosphorylation
- Oxidation
- Glycosylation
- Reduction
- Nitration
- Dephosphorylation
- Acetylation
For details, visit:
bosterbio.com/bosterbio-gene-info-cards/CYBB
bosterbio.com/bosterbio-gene-info-cards/CYBB
References
PMID: 12139950 by Jirapongsananuruk O., et al. CYBB mutation analysis in X-linked chronic granulomatous disease.
PMID: 2425263 by Royer-Pokora B., et al. Cloning the gene for an inherited human disorder -- chronic granulomatous disease -- on the basis of its chromosomal location.
15 Publications of Boster CYBB Antibodies & ELISA Kits
- PubMed ID: 10.1155/2019/5305014, The Protective Roles of Estrogen Receptor β in Renal Calcium Oxalate Crystal Fo...
- PubMed ID: 10.1152/ajpregu.00207.2021, Fetal e-cigarette exposure programs a neonatal brain hypoxic-ischemic sensitive ...
- PubMed ID: 10.1097/FJC.0000000000000534, Suppression of Oxidative Stress and Apoptosis in Electrically Stimulated Neonata...
- PubMed ID: 10.1038/srep30146, Maternal inflammation activated ROS-p38 MAPK predisposes offspring to heart dama...
- PubMed ID: 10.1038/srep23135, Graviola inhibits hypoxia-induced NADPH oxidase activity in prostate cancer cell...
- PubMed ID: 10.1016/j.ijbiomac.2017.05.191, β-d-glucan from Antrodia Camphorata ameliorates LPS-induced inflammation and RO...
- PubMed ID: -, Manuel R,Lima MdS,Dilly S,Daunay S,Abbe P,Pramil E,Solier S,Guillaumond F,Tubian...
- PubMed ID: 32112504, Zhou H,Wang H,Shi N,Wu F.Potential Protective Effects of the Water-Soluble Chine...
- PubMed ID: 27803283, Obligatory role for GPER in cardiovascular aging and disease^
- PubMed ID: 27443826, Maternal inflammation activated ROS-p38 MAPK predisposes offspring to heart dama...
- PubMed ID: 26979487, Graviola inhibits hypoxia-induced NADPH oxidase activity in prostate cancer cell...
- PubMed ID: 25499316, Du Z, Yang Q, Liu L, Li S, Zhao J, Hu J, Liu C, Qian D, Gao C. Neuroscience. 201...
- PubMed ID: 25324030, Du Z, Yang Q, Zhou T, Liu L, Li S, Chen S, Gao C. Mol Med Rep. 2014 Dec;10(6):28...
- PubMed ID: 25857968, Wang Y, Wang Y, Liu D, Wang W, Zhao H, Wang M, Yin H. Carbohydr Polym. 2015 Jul ...
- PubMed ID: 23894384, Liao Y, Liu P, Guo F, Zhang Zy, Zhang Z. Plos One. 2013 Jul 24;8(7):E68963. Doi:...
*More publications can be found for each product on its corresponding product page