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- Table of Contents
Cytochrome P450 2E1 Antibodies
AND CYP2E1 ELISA kits, Cytochrome P450 2E1 Proteins
Many biological assays use antibodies to detect Cytochrome P450 2E1, such as Western Blot (WB), ELISA, Flow Cytometry, Immunocytochemistry (IHC). These antibodies can be polyclonal or monoclonal, and react with Cytochrome P450 2E1 in Human, Mouse, Rat, and many other animal samples. Boster Bio use mainly mouse and rabbit to develop Cytochrome P450 2E1 antibodies...
Designing a Western blot for Cytochrome P450 2E1? The guide has the expected band size, antibodies backed by real blot images, the controls to run alongside, and protocols taken from published papers.
Open the CYP2E1 Western Blot GuideCYP2E1 Infographic by Boster Bio
All CYP2E1 Products
Product
Figures
Specificity
Applications
Price
Anti-Cytochrome P450 2E1/CYP2E1 Antibody Picoband®
14 Citations
Human, Mouse, Rat
ELISA, Flow Cytometry, IHC, WB
$370
Cat # A00672
100 μg/vial
Cat # A00672
100 μg/vial
Mouse, Rat
IHC, WB
$370
Cat # PB9190
100 μg/vial
Cat # PB9190
100 μg/vial
Human, Mouse, Rat
WB
$370
Cat # M00672-2
100 μg/vial
Cat # M00672-2
100 μg/vial
Human
IF, IHC, WB
$523
Cat # M00672-1
100 µl
Cat # M00672-1
100 µl
CYP2E1 Overview
Facts about Cytochrome P450 2E1.
Cytochrome P450 2E1 (CYP2E1)
Metabolizes several precarcinogens, drugs, and solvents to reactive metabolites. Inactivates numerous drugs and xenobiotics and also bioactivates many xenobiotic substrates for their hepatotoxic or carcinogenic forms.
.
Gene Information
| Human | |
|---|---|
| Gene Name: | CYP2E1 |
| Uniprot: | P05181 |
| Entrez: | 1571 |
Family
| Belongs to: |
|---|
| cytochrome P450 family |
Alternative Names
4-nitrophenol 2-hydroxylase; CPE1; CYP2Ecytochrome P450 2E1; CYPIIE1; cytochrome P450, family 2, subfamily E, polypeptide 1; cytochrome P450, subfamily IIE (ethanol-inducible), polypeptide 1; Cytochrome P450-J; EC 1.14.13.-; EC 1.14.13.n7; EC 1.14.14.1; flavoprotein-linked monooxygenase; microsomal monooxygenase; P450C2E; P450-J; xenobiotic monooxygenase
Molecular Weight
Mass (kDA):
56.849 kDA
Genomic Context
| Human | |
|---|---|
| Location: | 10q26.3 |
| Sequence: | 10; NC_000010.11 (133527363..133539123) |
Subcellular Localizations
Endoplasmic reticulum membrane; Peripheral membrane protein. Microsome membrane; Peripheral membrane protein. Mitochondrion inner membrane; Peripheral membrane protein. Post-translationally targeted to mitochondria. TOMM70 is required for the translocation across the mitochondrial outer membrane. After translocation into the matrix, associates with the inner membrane as a membrane extrinsic protein.
Diseases
- Malignant Neoplasms
- Liver Diseases
- Hepatotoxicity
- Injury To Liver
- Neoplasms
- Alcoholic Liver Diseases
- Drug-induced Liver Injury
- Carcinoma
- Liver Carcinoma
- Carcinogenesis
- Liver Damage
- Inflammation
Pathways
- Pathogenesis
- Excretion
- Conjugation
- Cell Death
- Dna Repair
- Transport
- Ethanol Oxidation
- Demethylation
- Cell Proliferation
- Localization
- Regeneration
- Cell Cycle
- Proteolysis
PTMs
- Hydroxylation
- Oxidation
- Demethylation
- Phosphorylation
- Reduction
- Acetylation
- Cleavage
- Nitration
Research Areas
- Lipid and Metabolism
For details, visit:
bosterbio.com/bosterbio-gene-info-cards/CYP2E1
bosterbio.com/bosterbio-gene-info-cards/CYP2E1
References
PMID: 3782137 by Song B.-J., et al. Complementary DNA and protein sequences of ethanol-inducible rat and human cytochrome P-450s. Transcriptional and post-transcriptional regulation of the rat enzyme.
PMID: 3233219 by Umeno M., et al. Human ethanol-inducible P450IIE1: complete gene sequence, promoter characterization, chromosome mapping, and cDNA-directed expression.
18 Publications of Boster Cytochrome P450 2E1 Antibodies & ELISA Kits
- PubMed ID: 10.3748/wjg.15.1829, Protective effect of tea polyphenols against paracetamol-induced hepatotoxicity ...
- PubMed ID: 10.3109/13880209.2014.898075, Effect of ammonium pyrrolidine dithiocarbamate (PDTC) on NF-κB activation and C...
- PubMed ID: 10.1142/S0192415X15500160, Hepatoprotective Effect of Kaempferol Against Alcoholic Liver Injury in Mice
- PubMed ID: 10.1080/13510002.2016.1239867, Protective effect of wild Corni fructus methanolic extract against acute alcohol...
- PubMed ID: 10.1016/j.toxlet.2011.11.030, Furocoumarins affect hepatic cytochrome P450 and renal organic ion transporters ...
- PubMed ID: 10.1016/j.tox.2017.04.001, The induction of cytochrome P450 2E1 by ethanol leads to the loss of synaptic pr...
- PubMed ID: 10.1016/j.jgr.2017.07.003, Ginsenoside Rk1 ameliorates paracetamol-induced hepatotoxicity in mice through i...
- PubMed ID: 10.1016/j.etap.2016.09.006, An improved in vitro method for screening toxin and medicine targeting CYP2E1
- PubMed ID: 10.1016/j.ejphar.2017.09.034, Fructose 1, 6-diphosphate prevents alcohol-induced liver injury through inhibiti...
- PubMed ID: 10.1016/j.biopha.2017.04.056, Total sesquiterpene glycosides from Loquat (Eriobotrya japonica) leaf alleviate ...
- PubMed ID: 10.1016/j.apsb.2017.04.002, Schisandra sphenanthera extract (Wuzhi Tablet) protects against chronic-binge an...
- PubMed ID: 10.1002/ptr.5867, Nephroprotective Effects of Anthocyanin from the Fruits of Panax ginseng (GFA) o...
- PubMed ID: -, Thida,M.,Li,B.,Zhang,X.,Chen,C.,& Zhang,X.(2021).Echinacoside alleviates acetami...
- PubMed ID: 33354276, Zhai T,Xu W,Liu Y,Qian K,Xiong Y,Chen Y.Honokiol Alleviates Methionine-Choline D...
- PubMed ID: 28924552, Schisandra sphenanthera extract (Wuzhi Tablet) protects against chronic-binge an...
- PubMed ID: 19370779, Chen X, Sun Ck, Han Gz, Peng Jy, Li Y, Liu Yx, Lv Yy, Liu Kx, Zhou Q, Sun Hj. Wo...
- PubMed ID: 25217484, Fan X, Jiang Y, Wang Y, Tan H, Zeng H, Wang Y, Chen P, Qu A, Gonzalez Fj, Huang ...
- PubMed ID: 25319358, Jiang Y, Fan X, Wang Y, Chen P, Zeng H, Tan H, Gonzalez Fj, Huang M, Bi H. Toxic...
*More publications can be found for each product on its corresponding product page