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- Table of Contents
DAPK1 Antibodies
AND DAPK1 ELISA kits, DAPK1 Proteins
Many biological assays use antibodies to detect DAPK1, such as Western Blot (WB), ELISA, Flow Cytometry, Immunocytochemistry (IHC). These antibodies can be polyclonal or monoclonal, and react with DAPK1 in Human, Mouse, Rat, and many other animal samples. Boster Bio use mainly mouse and rabbit to develop DAPK1 antibodies...
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DAPK1 Infographic by Boster Bio
All DAPK1 Products
Product
Figures
Specificity
Applications
Price
Human, Mouse, Rat
IF, IHC, ICC, WB
$370
Cat # M01161
100 μl
Cat # M01161
100 μl
DAPK1 Overview
Facts about Death-associated protein kinase 1.
Death-associated protein kinase 1 (DAPK1)
Calcium/calmodulin-dependent serine/threonine kinase involved in multiple cellular signaling pathways that activate cell survival, apoptosis, and autophagy. Regulates both type I apoptotic and type II autophagic cell deaths signal, depending on the mobile setting.
Phosphorylates PIN1 leading to inhibition of its catalytic activity, nuclear localization, and cellular function. Phosphorylates TPM1, improving stress fiber formation in endothelial cells.
Gene Information
| Human | |
|---|---|
| Gene Name: | DAPK1 |
| Uniprot: | P53355 |
| Entrez: | 1612 |
Family
| Belongs to: |
|---|
| protein kinase superfamily |
Alternative Names
DAPKDAP kinase 1; death-associated protein kinase 1; DKFZp781I035; EC 2.7.11; EC 2.7.11.1
Molecular Weight
Mass (kDA):
160.046 kDA
Genomic Context
| Human | |
|---|---|
| Location: | 9q21.33 |
| Sequence: | 9; NC_000009.12 (87497228..87708634) |
Tissue Specificity
Isoform 2 is expressed in normal intestinal tissue as well as in colorectal carcinomas.
Subcellular Localizations
[Isoform 1]: Cytoplasm. Cytoplasm, cytoskeleton. Colocalizes with MAP1B in the microtubules and cortical actin fibers.; [Isoform 2]: Cytoplasm. Cytoplasm, cytoskeleton.
Diseases
- Neoplasms
- Malignant Neoplasms
- Carcinoma
- Carcinogenesis
- Leukemia
- Malignant Squamous Cell Neoplasm
- Malignant Neoplasm Of Breast
- Mammary Neoplasms
- Malignant Paraganglionic Neoplasm
- Adenocarcinoma
- Neoplasm Metastasis
- Lung Neoplasms
Interacting Proteins
- BAG2
- BECN1
- KLHL20
- LRRK1
- LRRK2
- MAPK3
- PDCD6
- PKM
Pathways
- Methylation
- Dna Methylation
- Cell Death
- Gene Silencing
- Cell Cycle
- Dna Hypermethylation
- Cell Growth
- Autophagy
- Pathogenesis
- Programmed Cell Death
- Transport
- Dna Hypomethylation
- Regulation Of Gene Expression
PTMs
- Methylation
- Phosphorylation
- Demethylation
Research Areas
- Apoptosis
- Cancer
- Phospho-Specific
For details, visit:
bosterbio.com/bosterbio-gene-info-cards/DAPK1
bosterbio.com/bosterbio-gene-info-cards/DAPK1
References
PMID: 7828849 by Deiss L.P., et al. Identification of a novel serine/threonine kinase and a novel 15-kD protein as potential mediators of the gamma interferon-induced cell death.
PMID: 10629061 by Inbal B., et al. Death-associated protein kinase-related protein 1, a novel serine/threonine kinase involved in apoptosis.
2 Publications of Boster DAPK1 Antibodies & ELISA Kits
- PubMed ID: 23408147, Reduced expression levels of the death-associated protein kinase and E-cadherin ...
- PubMed ID: 24959233, DRP-1, ezrin and E-cadherin expression and the association with esophageal squam...
*More publications can be found for each product on its corresponding product page