DNA damage-binding protein 1 (DDB1)

Needed for DNA repair.

Binds to DDB2 to form the UV- damaged DNA-binding protein complex (the UV-DDB complicated ).

The UV- DDB complex may recognize UV-induced DNA damage and recruit proteins of the nucleotide excision repair pathway (the NER pathway) to initiate DNA repair. Also appears to function as a component of many distinct DCX (DDB1-CUL4-X-box) E3 ubiquitin-protein ligase complexes which mediate the ubiquitination and subsequent proteasomal degradation of target proteins.