DFFB Antibodies

DNA fragmentation factor subunit beta (DFFB)

Nuclease that induces DNA fragmentation and chromatin condensation during apoptosis. Degrades naked DNA and induces apoptotic morphology.

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Gene Information

Human
Gene Name:	DFFB
Uniprot:	O76075
Entrez:	1677

Family

Belongs to:
No superfamily

Alternative Names

CAD; CADCaspase-activated nuclease; Caspase-activated deoxyribonuclease; Caspase-activated DNase; CPAN; CPANDNA fragmentation factor 40 kDa subunit; DFF2; DFF40; DFF-40DFF40DFF2DNA fragmentation factor subunit beta; DFFB; DNA fragmentation factor, 40kDa, beta polypeptide (caspase-activated DNase); EC 3.-

Molecular Weight

Mass (kDA):
39.11 kDA

Genomic Context

Human
Location:	1p36.32
Sequence:	1; NC_000001.11 (3857267..3885429)

Subcellular Localizations

Cytoplasm. Nucleus.

Diseases

• Neoplasms
• Malignant Neoplasms
• Carcinoma
• Leukemia
• Lymphoma
• Ischemia
• Huntington Disease
• Burkitt Lymphoma
• Dna Degradation, Apoptotic
• Malignant Neoplasm Of Breast
• Trinucleotide Repeat Expansion
• Malignant Tumor Of Colon

• Endometriosis, Site Unspecified
• Oligodendroglioma
• Diabetes Mellitus
• Carcinogenesis
• Cerebral Ischemia
• Obesity
• Cholangiocarcinoma

Interacting Proteins

• DFFA

Pathways

• Cell Death
• Apoptotic Dna Fragmentation
• Programmed Cell Death
• Induction Of Apoptosis
• Localization
• Pathogenesis
• Transport
• Proteolysis
• Release Of Cytochrome C From Mitochondria
• Sensitization
• Translation
• Apoptotic Process
• Fertilization

• Sulfate Reduction
• Neurogenesis
• Keratinocyte Differentiation
• Oxidative Phosphorylation
• Histone Phosphorylation
• Nuclear Transport
• Execution Phase Of Apoptosis

PTMs

• Cleavage
• Phosphorylation
• Deacetylation

• Methylation
• Oxidation
• Dephosphorylation

• Ubiquitination

For details, visit:
bosterbio.com/bosterbio-gene-info-cards/DFFB

Boster Bio - Best Uses Of The DFFB Marker

You might be wondering what the Boster Bio is like compared to the Ang II if it is on your market for a Boster Bio. Both have similar uses so we've listed both below. Continue reading to learn more. Check out the BosterBio's Ang II review to get more tips and tricks. It is worth every penny! It is easy-to-use and will deliver the best results.

Ang II

Ang II is a protein with important roles in cardiovascular, renal, and cellular physiology. It has been implicated in tissue injury, autoimmunity, inflammation, as well as autoimmunity. It promotes oxidative and aging stress. This protein has many clinical applications. Here are a few examples:

Ang II causes inflammation in the brain through multiple pathways, including activation of AT1 receptors on cerebral vessels. Furthermore, the expression of GFAP in the hippocampal region is elevated, indicating increased astrocyte activation. Ang II stimulates brain inflammation, which increases blood pressure and PVN neuron count.

The role of Ang II has been implicated in senescence. The mice's lifespan is extended when Ang II is inhibited in the cardiovascular system. Other studies implicate this protein in senescence and ROS-induced damage. Age-related cerebral circulation problems are not seen in mice without the AT1 receptor. Drugs that target the AT1 signal may be effective in prolonging a person's life span.

In addition, Ang II is part of a putative pathway for COVID-19 infection. The COVID-19 peak of ANG II coincides with mild illness or hospitalization. Conversely, a failure to reach a peak in ANG II during SARS CoV-2 infection is associated a poor prognosis. However, the prognosis is inversely correlated to the amount ANG II in your blood.

ANG II conversion is dependent on the tACE2 enzyme. SARS-CoV-2 virus infects the liver and causes partial blockade. Increasing tACE2 can increase ANG II but decrease sACE2. Reduced sACE2 results is increased viral entry, replication, and ang II.

Ang II can inhibit inflammation and improve vascular remodeling. In each group, it was administered to 7 animals. After treatment, the animal's aorta were collected and stored in buffered formin 4%. The aorta was then paraplast embedded and histologically evaluated. At day 4 and 7, Ang II-treated animals had higher SBPs than control animals.

Ang II improves microglial processes. The larger process area is indicative of increased lysosomal and metabolic activity. It also increases the ability for microglia to reorient towards injury. Ang II also induces extracellular digestive activity, which suggests that microglia may be involved in synaptic remodelling. EM micrographs display complex morphologies and microglial functions.

Ang II may be a biomarker for the onset of vascular diseases and also play a part in autoimmune conditions. EAE mice, the model for human MS in mice, show elevated levels of Ang II within peripheral CD4+T cell populations. The AT1 receptor plays an important role in Th2/Th27-mediated multiplesclerosis.

DFFB Marker

The DFFB supports the production and distribution of films from diverse cultures. They have screened their films at more than 200 film festivals across the globe. They were awarded 25 awards in 2018. Staff from DFFB hosted a Berlinale party in 2018 for students and filmmakers. In addition, a panel discussion was held to discuss the challenges facing independent producers, how to promote different actors, and the changes needed in the film industry.