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During the osteoblast to osteocyte transition phase it is phosphorylated and exported to the extracellular matrix, where it regulates nucleation of hydroxyapatite. .
|Sequence:||4; NC_000004.12 (87650280..87664357)|
Expressed in tooth particularly in odontoblast, ameloblast and cementoblast.
Nucleus. Cytoplasm. Secreted, extracellular space, extracellular matrix. In proliferating preosteoblasts it is nuclear, during early maturation stage is cytoplasmic and in mature osteoblast localizes in the mineralized matrix. Export from the nucleus of differentiating osteoblast is triggered by the release of calcium from intracellular stores followed by a massive influx of this pool of calcium into the nucleus.