Dentin matrix acidic phosphoprotein 1 (DMP1)

May have a dual function during osteoblast differentiation. In the nucleus of undifferentiated osteoblasts, unphosphorylated form acts as a transcriptional component for activation of osteoblast-specific genes like osteocalcin.

During the osteoblast to osteocyte transition phase it is phosphorylated and exported to the extracellular matrix, where it regulates nucleation of hydroxyapatite. .