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- Table of Contents
DNMT3B Antibodies
AND DNMT3B ELISA kits, DNMT3B Proteins
Many biological assays use antibodies to detect DNMT3B, such as Western Blot (WB), ELISA, Flow Cytometry, Immunocytochemistry (IHC). These antibodies can be polyclonal or monoclonal, and react with DNMT3B in Human, Mouse, Rat, and many other animal samples. Boster Bio use mainly mouse and rabbit to develop DNMT3B antibodies...
Designing a Western blot for DNMT3B? The guide has the expected band size, antibodies backed by real blot images, the controls to run alongside, and protocols taken from published papers.
Open the DNMT3B Western Blot GuideDNMT3B Infographic by Boster Bio
All DNMT3B Products
Product
Figures
Specificity
Applications
Price
Anti-DNMT3B Antibody Picoband®
1 Citations
Human, Monkey, Rat
ELISA, Flow Cytometry, WB
$370
Cat # A00319-4
100 μg/vial
Cat # A00319-4
100 μg/vial
Human, Mouse, Rat
IF, ICC, WB
$370
Cat # M00319
100 μl
Cat # M00319
100 μl
Human, Monkey, Mouse, Rat
ELISA, Flow Cytometry, WB
$370
Cat # A00319-5
100 μg/vial
Cat # A00319-5
100 μg/vial
Human, Monkey, Mouse, Rat
ELISA, Flow Cytometry, WB
$370
Cat # A00319-3
100 μg/vial
Cat # A00319-3
100 μg/vial
Human, Monkey
ELISA, Flow Cytometry, WB
$370
Cat # A00319-2
100 μg/vial
Cat # A00319-2
100 μg/vial
DNMT3B Overview
Facts about DNA (cytosine-5)-methyltransferase 3B.
DNA (cytosine-5)-methyltransferase 3B (DNMT3B)
Required for genome-wide de novo methylation and is essential for the establishment of DNA methylation patterns during development. DNA methylation is coordinated with methylation of histones.
May preferentially methylates nucleosomal DNA within the nucleosome core region. May function as transcriptional co- repressor by associating with CBX4 and independently of DNA methylation.
Gene Information
| Human | |
|---|---|
| Gene Name: | DNMT3B |
| Uniprot: | Q9UBC3 |
| Entrez: | 1789 |
Family
| Belongs to: |
|---|
| class I-like SAM-binding methyltransferase superfamily |
Alternative Names
DNA (cytosine-5-)-methyltransferase 3 beta; DNA (cytosine-5)-methyltransferase 3B; DNA methyltransferase HsaIIIB; DNA MTase HsaIIIB; DNMT3B; EC 2.1.1.37; ICF; ICF1; M.HsaIIIB
Molecular Weight
Mass (kDA):
95.751 kDA
Genomic Context
| Human | |
|---|---|
| Location: | 20q11.21 |
| Sequence: | 20; NC_000020.11 (32762385..32809356) |
Tissue Specificity
Ubiquitous; highly expressed in fetal liver, heart, kidney, placenta, and at lower levels in spleen, colon, brain, liver, small intestine, lung, peripheral blood mononuclear cells, and skeletal muscle. Isoform 1 is expressed in all tissues except brain, skeletal muscle and PBMC, 3 is ubiquitous, 4 is expressed in all tissues except brain, skeletal muscle, lung and prostate and 5 is detectable only in testis and at very low level in brain and prostate.
Subcellular Localizations
Nucleus.
Diseases
- Malignant Neoplasms
- Neoplasms
- Carcinoma
- Cell Transformation, Neoplastic
- Immunologic Deficiency Syndromes
- Carcinogenesis
- Malignant Paraganglionic Neoplasm
- Colorectal Cancer
- Leukemia
- Malignant Neoplasm Of Breast
- Malignant Tumor Of Colon
- Malignant Neoplasm Of Lung
Interacting Proteins
- EED
- EHMT2
- EZH2
- SUMO1
- UBE2I
- UHRF1
- ZHX1
Pathways
- Methylation
- Dna Methylation
- Demethylation
- Gene Silencing
- Dna Hypomethylation
- Cell Cycle
- Pathogenesis
- Dna Hypermethylation
- Localization
- Cell Growth
- Dna Demethylation
- Cell Proliferation
- Cell Differentiation
PTMs
- Methylation
- Demethylation
- Acetylation
- Phosphorylation
- Deacetylation
- Reduction
- Cleavage
Research Areas
- Chromatin Research
- Epigenetics
For details, visit:
bosterbio.com/bosterbio-gene-info-cards/DNMT3B
bosterbio.com/bosterbio-gene-info-cards/DNMT3B
References
PMID: 10433969 by Xie S., et al. Cloning, expression and chromosome locations of the human DNMT3 gene family.
PMID: 10647011 by Xu G.-L., et al. Chromosome instability and immunodeficiency syndrome caused by mutations in a DNA methyltransferase gene.