Histone-lysine N-methyltransferase EZH2 (EZH2)

Polycomb group (PcG) protein. Catalytic subunit of the PRC2/EED-EZHtwo complex, which methylates'Lys-9' (H3K9me) and'Lys- 27' (H3K27me) of histone H3, leading to transcriptional repression of the affected target gene.

Willing to mono-, di- and trimethylate'Lys-27' of histone H3 to form H3K27me1, H3K27me2 and H3K27me3, respectively. Displays a preference for substrates with less methylation, loses action when increasingly more methyl groups are incorporated into H3K27, H3K27me0 > H3K27me1 > H3K27me2 (PubMed:22323599).