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- Table of Contents
EZH2 Antibodies
AND EZH2 ELISA kits, EZH2 Proteins
Many biological assays use antibodies to detect EZH2, such as Western Blot (WB), ELISA, Flow Cytometry, Immunocytochemistry (IHC). These antibodies can be polyclonal or monoclonal, and react with EZH2 in Human, Mouse, Rat, and many other animal samples. Boster Bio use mainly mouse and rabbit to develop EZH2 antibodies...
Designing a Western blot for EZH2? The guide has the expected band size, antibodies backed by real blot images, the controls to run alongside, and protocols taken from published papers.
Open the EZH2 Western Blot GuideDesigning an IHC experiment for EZH2? The guide has the expected staining pattern, antigen retrieval and fixation, antibodies backed by real IHC images, the tissue controls to run alongside, and protocols taken from published papers.
Open the EZH2 IHC GuideEZH2 Infographic by Boster Bio
All EZH2 Products
Product
Figures
Specificity
Applications
Price
Human, Mouse, Rat
ELISA, Flow Cytometry, IP, WB
$370
Cat # A00050-1
100 μg/vial
Cat # A00050-1
100 μg/vial
Human, Mouse, Rat
Flow Cytometry, IF, IHC, ICC, WB
$370
Cat # M00050-1
100 μl
Cat # M00050-1
100 μl
Human, Mouse, Rat
ELISA, IP, IF, IHC, WB
$146
Cat # M00050-2
20μL, 40μL, 100μL, 200μL
Cat # M00050-2
20μL, 40μL, 100μL, 200μL
EZH2 Overview
Facts about Histone-lysine N-methyltransferase EZH2.
Histone-lysine N-methyltransferase EZH2 (EZH2)
Polycomb group (PcG) protein. Catalytic subunit of the PRC2/EED-EZHtwo complex, which methylates'Lys-9' (H3K9me) and'Lys- 27' (H3K27me) of histone H3, leading to transcriptional repression of the affected target gene.
Willing to mono-, di- and trimethylate'Lys-27' of histone H3 to form H3K27me1, H3K27me2 and H3K27me3, respectively. Displays a preference for substrates with less methylation, loses action when increasingly more methyl groups are incorporated into H3K27, H3K27me0 > H3K27me1 > H3K27me2 (PubMed:22323599).
Gene Information
| Human | |
|---|---|
| Gene Name: | EZH2 |
| Uniprot: | Q15910 |
| Entrez: | 2146 |
Family
| Belongs to: |
|---|
| class V-like SAM-binding methyltransferase superfamily |
Alternative Names
EC 2.1.1; EC 2.1.1.43; enhancer of zeste (Drosophila) homolog 2; enhancer of zeste 2; enhancer of zeste homolog 2 (Drosophila); Enhancer of zeste homolog 2; ENX1; ENX-1KMT6EZH1KMT6A; EZH2; histone-lysine N-methyltransferase EZH2; KMT6; Lysine N-methyltransferase 6; MGC9169
Molecular Weight
Mass (kDA):
85.363 kDA
Genomic Context
| Human | |
|---|---|
| Location: | 7q36.1 |
| Sequence: | 7; NC_000007.14 (148807374..148884344, complement) |
Tissue Specificity
Expressed in many tissues. Overexpressed in numerous tumor types including carcinomas of the breast, colon, larynx, lymphoma and testis.
Subcellular Localizations
Nucleus.
Diseases
- Malignant Neoplasms
- Neoplasms
- Carcinoma
- Cell Transformation, Neoplastic
- Malignant Neoplasm Of Prostate
- Neoplasm Metastasis
- Prostatic Neoplasms
- Malignant Paraganglionic Neoplasm
- Malignant Neoplasm Of Breast
- Leukemia
- Mammary Neoplasms
- Cell Invasion
Interacting Proteins
- ASXL1
- ATRX
- CEP63
- DNMT1
- DNMT3A
- DNMT3B
- Dnmt3l
- EED
- PHF1
- RARA
Pathways
- Methylation
- Cell Cycle
- Gene Silencing
- Cell Proliferation
- Dna Methylation
- Histone Methylation
- Pathogenesis
- Cell Growth
- Rna Interference
- Cell Differentiation
- Oncogenesis
- Histone Modification
- Senescence
PTMs
- Methylation
- Phosphorylation
- Acetylation
- Demethylation
- Ubiquitination
- Deacetylation
Research Areas
- Breast Cancer
- Cancer
- Chromatin Research
- Phospho-Specific
- Prostate Cancer
For details, visit:
bosterbio.com/bosterbio-gene-info-cards/EZH2
bosterbio.com/bosterbio-gene-info-cards/EZH2
References
PMID: 8954776 by Chen H., et al. Cloning of a human homolog of the Drosophila enhancer of zeste gene (EZH2) that maps to chromosome 21q22.2.
PMID: 9214638 by Laible G., et al. Mammalian homologues of the Polycomb-group gene Enhancer of zeste mediate gene silencing in Drosophila heterochromatin and at S. cerevisiae telomeres.
1 Publications of Boster EZH2 Antibodies & ELISA Kits
- PubMed ID: 26265454, Enhancer of zeste homolog 2 silencing inhibits tumor growth and lung metastasis ...
*More publications can be found for each product on its corresponding product page