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- Table of Contents
FBL Antibodies
AND FBL ELISA kits, FBL Proteins
Many biological assays use antibodies to detect FBL, such as Western Blot (WB), ELISA, Flow Cytometry, Immunocytochemistry (IHC). These antibodies can be polyclonal or monoclonal, and react with FBL in Human, Mouse, Rat, and many other animal samples. Boster Bio use mainly mouse and rabbit to develop FBL antibodies...
Designing a Western blot for FBL? The guide has the expected band size, antibodies backed by real blot images, the controls to run alongside, and protocols taken from published papers.
Open the FBL Western Blot GuideFBL Infographic by Boster Bio
All FBL Products
Product
Figures
Specificity
Applications
Price
Human
ELISA, Flow Cytometry, IF, ICC, WB
$370
Cat # A02970-1
100 μg/vial
Cat # A02970-1
100 μg/vial
Human, Mouse, Rat
Flow Cytometry, IP, IF, IHC, ICC, WB
$370
Cat # M03178
100 μl
Cat # M03178
100 μl
Human, Monkey
ELISA, Flow Cytometry, IF, ICC, WB
$370
Cat # A03178-1
100 μg/vial
Cat # A03178-1
100 μg/vial
Human, Mouse, Rat
ELISA, IF, IHC-P, WB
$481
Cat # A15331
0.1 mg
Cat # A15331
0.1 mg
Human, Mouse, Rat
ELISA, IP, IF, IHC, WB
$146
Cat # M03178-6
20μL, 40μL, 100μL, 200μL
Cat # M03178-6
20μL, 40μL, 100μL, 200μL
FBL Overview
Facts about rRNA 2'-O-methyltransferase fibrillarin.
rRNA 2'-O-methyltransferase fibrillarin (FBL)
S-adenosyl-L-methionine-dependent methyltransferase that has the ability to methylate both RNAs and proteins. Involved in pre-rRNA processing by catalyzing the site-specific two'-hydroxyl methylation of ribose moieties in pre-ribosomal RNA.
Site specificity is provided by a guide RNA that base pairs with the substrate. Methylation occurs at a characteristic distance from the sequence involved in base pairing with the guide RNA.
Gene Information
| Human | |
|---|---|
| Gene Name: | FBL |
| Uniprot: | P22087 |
| Entrez: | 2091 |
Family
| Belongs to: |
|---|
| methyltransferase superfamily |
Alternative Names
EC 2.1.1,34-kD nucleolar scleroderma antigen; EC 2.1.1.-; EC 2.1.1.37; FIB; FIB1,34 kDa nucleolar scleroderma antigen; fibrillarin; FLRNrRNA 2'-O-methyltransferase fibrillarin; RNA, U3 small nucleolar interacting protein 1; RNU3IP1
Molecular Weight
Mass (kDA):
33.784 kDA
Genomic Context
| Human | |
|---|---|
| Location: | 19q13.2 |
| Sequence: | 19; NC_000019.10 (39834458..39846395, complement) |
Subcellular Localizations
Nucleus, nucleolus. Fibrillar region of the nucleolus.
Diseases
- Neoplasms
- Leukemia
- Acute Erythroblastic Leukemia
- Malignant Neoplasms
- Carcinoma
- Primary Central Nervous System Lymphoma
- Lymphoma
- Infective Disorder
- Staphylococcal Infections
- Malignant Neoplasm Of Breast
- Mammary Neoplasms
- Toxoplasmosis, Cerebral
- Nervousness
Interacting Proteins
- DDX5
- RRP1B
- TGS1
Pathways
- Immune Response
- Cell Growth
- Localization
- Secretion
- Colony Morphology
- Aerobic Respiration
- Fertilization
- Virulence
- Chromosome Segregation
- Killer Activity
- Cytokinesis
- Embryo Development
- Cell Division
PTMs
- Acetylation
- Isopeptide bond
Research Areas
- Cellular Markers
- Core ESC-Like Genes
- Neuroscience
- Nuclear Envelope Markers
- Stem Cell Markers
For details, visit:
bosterbio.com/bosterbio-gene-info-cards/FBL
bosterbio.com/bosterbio-gene-info-cards/FBL
References
PMID: 1846968 by Aris J.P., et al. cDNA cloning and sequencing of human fibrillarin, a conserved nucleolar protein recognized by autoimmune antisera.
PMID: 2026646 by Jansen R.P., et al. Evolutionary conservation of the human nucleolar protein fibrillarin and its functional expression in yeast.