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- Table of Contents
FHIT Antibodies
AND FHIT ELISA kits, FHIT Proteins
Many biological assays use antibodies to detect FHIT, such as Western Blot (WB), ELISA, Flow Cytometry, Immunocytochemistry (IHC). These antibodies can be polyclonal or monoclonal, and react with FHIT in Human, Mouse, Rat, and many other animal samples. Boster Bio use mainly mouse and rabbit to develop FHIT antibodies...
Designing a Western blot for FHIT? The guide has the expected band size, antibodies backed by real blot images, the controls to run alongside, and protocols taken from published papers.
Open the FHIT Western Blot GuideFHIT Infographic by Boster Bio
All FHIT Products
Product
Figures
Specificity
Applications
Price
Human
IHC, WB
$370
Cat # M01204-1
100 μg/vial
Cat # M01204-1
100 μg/vial
Human, Rat
Flow Cytometry, IF, IHC, ICC, WB
$370
Cat # PB9181
100 μg/vial
Cat # PB9181
100 μg/vial
Human
Flow Cytometry, IF, ICC, WB
$370
Cat # M01200
100 μg/vial
Cat # M01200
100 μg/vial
Human, Mouse, Rat
IHC, WB
$523
Cat # M01200-2
100 µl
Cat # M01200-2
100 µl
Human
ELISA
$480
Cat # EKC1215
1 kit, containing one 96-well plate and all necessary reagents
Cat # EKC1215
1 kit, containing one 96-well plate and all necessary reagents
FHIT Overview
Facts about Bis(5'-adenosyl)-triphosphatase.
Bis(5'-adenosyl)-triphosphatase (FHIT)
Plays a role in the induction of apoptosis via SRC and AKT1 signaling pathways. Inhibits MDM2-mediated proteasomal degradation of p53/TP53 and thereby plays a role in p53/TP53-mediated apoptosis.
Gene Information
| Human | |
|---|---|
| Gene Name: | FHIT |
| Uniprot: | P49789 |
| Entrez: | 2272 |
Family
| Belongs to: |
|---|
| No superfamily |
Alternative Names
AP3A hydrolase; AP3AaseFRA3Bbis(5'-adenosyl)-triphosphatase; Diadenosine 5'-5'''-P1; dinucleosidetriphosphatase; EC 3.6.1.29; fragile histidine triad gene; Fragile histidine triad protein; P3-triphosphate hydrolase; tumor suppressor protein
Molecular Weight
Mass (kDA):
16.858 kDA
Genomic Context
| Human | |
|---|---|
| Location: | 3p14.2 |
| Sequence: | 3; NC_000003.12 (59747277..61251461, complement) |
Tissue Specificity
Low levels expressed in all tissues tested. Phospho-FHIT observed in liver and kidney, but not in brain and lung. Phospho-FHIT undetected in all tested human tumor cell lines.
Subcellular Localizations
Cytoplasm. Mitochondrion. Nucleus.
Diseases
- Neoplasms
- Malignant Neoplasms
- Carcinoma
- Carcinogenesis
- Malignant Squamous Cell Neoplasm
- Malignant Neoplasm Of Lung
- Cell Transformation, Neoplastic
- Lung Neoplasms
- Adenocarcinoma
- Neoplasm Metastasis
- Malignant Paraganglionic Neoplasm
- Non-small Cell Lung Carcinoma
- Mammary Neoplasms
Interacting Proteins
- CTNNB1
- LEF1
Pathways
- Methylation
- Pathogenesis
- Cell Cycle
- Cell Proliferation
- Dna Methylation
- Cell Growth
- Reverse Transcription
- Mismatch Repair
- Dna Repair
- Cell Death
- Oncogenesis
- Induction Of Apoptosis
- Cell Differentiation
PTMs
- Methylation
- Phosphorylation
- Cleavage
- Demethylation
Research Areas
- Apoptosis
- Cancer
- Cellular Markers
- Lipid and Metabolism
- Tumor Suppressors
For details, visit:
bosterbio.com/bosterbio-gene-info-cards/FHIT
bosterbio.com/bosterbio-gene-info-cards/FHIT
References
PMID: 8598045 by Ohta M., et al. The FHIT gene, spanning the chromosome 3p14.2 fragile site and renal carcinoma-associated t(3;8) breakpoint, is abnormal in digestive tract cancers.
PMID: 9012482 by Druck T., et al. Structure and expression of the human FHIT gene in normal and tumor cells.
2 Publications of Boster FHIT Antibodies & ELISA Kits
- PubMed ID: 3000101, Neuroprotective Properties of Picroside II in a Rat Model of Focal Cerebral Isch...
- PubMed ID: 21151457, Li Q, Li Z, Xu Xy, Guo Yl, Du F. Int J Mol Sci. 2010 Nov 16;11(11):4580-90. Doi:...
*More publications can be found for each product on its corresponding product page