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- Table of Contents
FLT3 Antibodies
AND FLT3 ELISA kits, FLT3 Proteins
Many biological assays use antibodies to detect FLT3, such as Western Blot (WB), ELISA, Flow Cytometry, Immunocytochemistry (IHC). These antibodies can be polyclonal or monoclonal, and react with FLT3 in Human, Mouse, Rat, and many other animal samples. Boster Bio use mainly mouse and rabbit to develop FLT3 antibodies...
Designing a Western blot for FLT3? The guide has the expected band size, antibodies backed by real blot images, the controls to run alongside, and protocols taken from published papers.
Open the FLT3 Western Blot GuideFLT3 Infographic by Boster Bio
All FLT3 Products
Product
Figures
Specificity
Applications
Price
Mouse
ELISA
$499
Cat # EK0355
96 wells/kit, with removable strips.
Cat # EK0355
96 wells/kit, with removable strips.
Human, Mouse, Rat
Flow Cytometry, IF, IHC, WB
$370
Cat # A04997-3
100 µg/vial
Cat # A04997-3
100 µg/vial
Human
ELISA
$499
Cat # EK0354
96 wells/kit, with removable strips.
Cat # EK0354
96 wells/kit, with removable strips.
Human, Mouse, Rat
ELISA, Flow Cytometry, IHC, WB
$370
Cat # A04988-1
100 μg/vial
Cat # A04988-1
100 μg/vial
Human
ELISA, Flow Cytometry, IF, IHC, ICC, WB
$370
Cat # A05006-1
100 µg/vial
Cat # A05006-1
100 µg/vial
Human, Mouse, Rat
ELISA, Flow Cytometry, IF, ICC, WB
$370
Cat # A04992-2
100 µg/vial
Cat # A04992-2
100 µg/vial
Human, Mouse, Rat
ELISA, Flow Cytometry, WB
$370
Cat # A04989-1
100 μg/vial
Cat # A04989-1
100 μg/vial
Human
ELISA
$499
Cat # EK0352
96 wells/kit, with removable strips.
Cat # EK0352
96 wells/kit, with removable strips.
Human
Flow Cytometry, IF, IHC, ICC, WB
$370
Cat # A00193-3
100 μg/vial
Cat # A00193-3
100 μg/vial
Human, Mouse, Rat
ELISA, Flow Cytometry, IF, IHC, ICC, WB
$370
Cat # A00195-1
100 μg/vial
Cat # A00195-1
100 μg/vial
Human, Mouse
ELISA, Flow Cytometry, IF, ICC, WB
$370
Cat # A00190-2
100 μg/vial
Cat # A00190-2
100 μg/vial
Mouse, Rat
ELISA, Flow Cytometry, WB
$370
Cat # A00188-4
100 μg/vial
Cat # A00188-4
100 μg/vial
Human
ELISA, Flow Cytometry, Functional Assay, Kinetics
$486
Cat # M00188-1
100 μg
Cat # M00188-1
100 μg
SDS-PAGE, Bioactivity
$294
Cat # PROTP49771-9
Starting from 10ug
Cat # PROTP49771-9
Starting from 10ug
Mouse
Cell Culture
$77
Cat # PROTP49772-4
5ug,20ug,100ug
Cat # PROTP49772-4
5ug,20ug,100ug
Human
Cell Culture
$77
Cat # PROTP49771-7
5ug,20ug,100ug
Cat # PROTP49771-7
5ug,20ug,100ug
Swine
Cell Culture
$154
Cat # PROTD2K7D6
5ug,20ug
Cat # PROTD2K7D6
5ug,20ug
Human
ELISA
$540
Cat # EKC2563
1 kit, containing two 96-well plates and all necessary reagents
Cat # EKC2563
1 kit, containing two 96-well plates and all necessary reagents
Human, Mouse
ELISA
$540
Cat # EKC2562
1 kit, containing two 96-well plates and all necessary reagents
Cat # EKC2562
1 kit, containing two 96-well plates and all necessary reagents
Human, Mouse
ELISA
$540
Cat # EKC2071
1 kit, containing two 96-well plates and all necessary reagents
Cat # EKC2071
1 kit, containing two 96-well plates and all necessary reagents
Human, Mouse
ELISA
$480
Cat # EKC1219
1 kit, containing one 96-well plate and all necessary reagents
Cat # EKC1219
1 kit, containing one 96-well plate and all necessary reagents
FLT3 Overview
Facts about Receptor-type tyrosine-protein kinase FLT3.
Receptor-type tyrosine-protein kinase FLT3 (FLT3)
Tyrosine-protein kinase that acts as cell-surface receptor for the cytokine FLT3LG and modulates differentiation, proliferation and survival of hematopoietic progenitor cells and of dendritic cells. Promotes phosphorylation of SHC1 and AKT1, and activation of the downstream effector MTOR.
Promotes activation of RAS signaling and phosphorylation of downstream kinases, such as MAPK1/ERK2 and/or MAPK3/ERK1. Promotes phosphorylation of FES, FER, PTPN6/SHP, PTPN11/SHP-2, PLCG1, and STAT5A and/or STAT5B.
Gene Information
| Human | |
|---|---|
| Gene Name: | FLT3 |
| Uniprot: | P36888 |
| Entrez: | 2322 |
Family
| Belongs to: |
|---|
| protein kinase superfamily |
Alternative Names
CD135 antigen; CD135; EC 2.7.10; fetal liver kinase 2; FL cytokine receptor; FLK2; Flk-2; FLT3 receptor tyrosine kinase; Flt3; Flt-3; Fms-like tyrosine kinase 3; fms-related tyrosine kinase 3; growth factor receptor tyrosine kinase type III; Stem cell tyrosine kinase 1; STK-1; STK1EC 2.7.10.1; Tyrosine-protein kinase receptor FLT3
Molecular Weight
Mass (kDA):
112.903 kDA
Genomic Context
| Human | |
|---|---|
| Location: | 13q12.2 |
| Sequence: | 13; NC_000013.11 (28003274..28100587, complement) |
Tissue Specificity
Detected in bone marrow, in hematopoietic stem cells, in myeloid progenitor cells and in granulocyte/macrophage progenitor cells (at protein level). Detected in bone marrow, liver, thymus, spleen and lymph node, and at low levels in kidney and pancreas. Highly expressed in T-cell leukemia.
Subcellular Localizations
Membrane; Single-pass type I membrane protein. Endoplasmic reticulum lumen. Constitutively activated mutant forms with internal tandem duplications are less efficiently transported to the cell surface and a significant proportion is retained in an immature form in the endoplasmic reticulum lumen. The activated kinase is rapidly targeted for degradation.
Diseases
- Leukemia
- Leukemia, Myelocytic, Acute
- Myeloid Leukemia
- Malignant Neoplasms
- Neoplasms
- Flt3 Internal Tandem Duplication
- Acute Lymphocytic Leukemia
- Acute Promyelocytic Leukemia
- Leukemogenesis
- Dysmyelopoietic Syndromes
- Cell Transformation, Neoplastic
- Acute Leukemia
Interacting Proteins
- ABL1
- ABL2
- CRK
- CRKL
- FYN
- GRB10
- IKBKG
- LCK
- PIK3R1
- PTPRJ
Pathways
- Pathogenesis
- Cell Proliferation
- Cell Cycle
- Cell Growth
- Cell Development
- Cell Death
- Angiogenesis
- Localization
- Drug Resistance
- Methylation
- Induction Of Apoptosis
- Cell Differentiation
- Cell Cycle Arrest
PTMs
- Phosphorylation
- Methylation
- Dephosphorylation
- Cleavage
- Acetylation
Research Areas
- Cell Cycle and Replication
- Phospho-Specific
For details, visit:
bosterbio.com/bosterbio-gene-info-cards/FLT3
bosterbio.com/bosterbio-gene-info-cards/FLT3
References
PMID: 7507245 by Small D., et al. STK-1, the human homolog of Flk-2/Flt-3, is selectively expressed in CD34+ human bone marrow cells and is involved in the proliferation of early progenitor/stem cells.
PMID: 8394751 by Rosnet O., et al. Human FLT3/FLK2 gene: cDNA cloning and expression in hematopoietic cells.
3 Publications of Boster FLT3 Antibodies & ELISA Kits
- PubMed ID: PMID:25674205, The role of RIP1 and RIP3 in the development of aplastic anemia induced by cyclo...
- PubMed ID: , FGL2 promotes tumor progression in the CNS by suppressing CD103 + dendritic cell...
- PubMed ID: 25674205, Chen Yf, Zhao Zq, Wu Zm, Zou Zy, Luo Xj, Li J, Xie C, Liang Y. Int J Clin Exp Pa...
*More publications can be found for each product on its corresponding product page