Glutamate receptor ionotropic, NMDA 1 (GRIN1)

Component of NMDA receptor complexes that function as heterotetrameric, ligand-gated ion channels with high calcium permeability and voltage-dependent sensitivity to magnesium. Channel activation requires binding of the neurotransmitter glutamate into the epsilon subunit, glycine binding to the zeta subunit, plus membrane depolarization to get rid of channel inhibition by Mg(2+) (PubMed:7685113, PubMed:28126851, PubMed:26919761, PubMed:26875626, PubMed:28105280).

Sensitivity to glutamate and channel kinetics are determined by the subunit composition (PubMed:26919761). .