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- Table of Contents
GRIN1 Antibodies
AND GRIN1 ELISA kits, GRIN1 Proteins
Many biological assays use antibodies to detect GRIN1, such as Western Blot (WB), ELISA, Flow Cytometry, Immunocytochemistry (IHC). These antibodies can be polyclonal or monoclonal, and react with GRIN1 in Human, Mouse, Rat, and many other animal samples. Boster Bio use mainly mouse and rabbit to develop GRIN1 antibodies...
Designing a Western blot for GRIN1? The guide has the expected band size, antibodies backed by real blot images, the controls to run alongside, and protocols taken from published papers.
Open the GRIN1 Western Blot GuideGRIN1 Infographic by Boster Bio
All GRIN1 Products
Product
Figures
Specificity
Applications
Price
Anti-NMDAR1/GRIN1 Antibody Picoband®
8 Citations
Human, Mouse, Rat
IHC, WB
$370
Cat # PA1222
100 μg/vial
Cat # PA1222
100 μg/vial
Anti-ERM/Etv5 Antibody Picoband®
1 Citations
Human, Mouse, Rat
ELISA, Flow Cytometry, IF, ICC, WB
$370
Cat # A01809-2
100 μg/vial
Cat # A01809-2
100 μg/vial
Human, Mouse, Rat
ELISA, Flow Cytometry, WB
$370
Cat # A01810-2
100 μg/vial
Cat # A01810-2
100 μg/vial
Human, Mouse, Rat
ELISA, IF, IHC
$380
Cat # A01808S890
100ul
Cat # A01808S890
100ul
Human, Mouse, Rat
ELISA, IF, IHC, WB
$380
Cat # A01808S896-1
100ul
Cat # A01808S896-1
100ul
Human, Mouse, Rat
ELISA
$540
Cat # EKC2480
1 kit, containing two 96-well plates and all necessary reagents
Cat # EKC2480
1 kit, containing two 96-well plates and all necessary reagents
Human, Mouse, Rat
ELISA
$540
Cat # EKC2165
1 kit, containing two 96-well plates and all necessary reagents
Cat # EKC2165
1 kit, containing two 96-well plates and all necessary reagents
Human, Mouse, Rat
ELISA
$480
Cat # EKC1404
1 kit, containing one 96-well plate and all necessary reagents
Cat # EKC1404
1 kit, containing one 96-well plate and all necessary reagents
Human, Mouse, Rat
ELISA, IF, IHC, WB
$380
Cat # A01808S897-1
100ul
Cat # A01808S897-1
100ul
GRIN1 Overview
Facts about Glutamate receptor ionotropic, NMDA 1.
Glutamate receptor ionotropic, NMDA 1 (GRIN1)
Component of NMDA receptor complexes that function as heterotetrameric, ligand-gated ion channels with high calcium permeability and voltage-dependent sensitivity to magnesium. Channel activation requires binding of the neurotransmitter glutamate into the epsilon subunit, glycine binding to the zeta subunit, plus membrane depolarization to get rid of channel inhibition by Mg(2+) (PubMed:7685113, PubMed:28126851, PubMed:26919761, PubMed:26875626, PubMed:28105280).
Sensitivity to glutamate and channel kinetics are determined by the subunit composition (PubMed:26919761). .
Gene Information
| Human | |
|---|---|
| Gene Name: | GRIN1 |
| Uniprot: | Q05586 |
| Entrez: | 2902 |
Family
| Belongs to: |
|---|
| glutamate-gated ion channel (TC 1.A.10.1) family |
Alternative Names
glutamate [NMDA] receptor subunit zeta-1; glutamate receptor, ionotropic, N-methyl D-aspartate 1; NMDA1; NMDAR1glutamate [NMDA] receptor subunit zeta 1; NMD-R1; N-methyl-D-aspartate receptor channel, subunit zeta-1; N-methyl-D-aspartate receptor subunit NR1; NR1
Molecular Weight
Mass (kDA):
105.373 kDA
Genomic Context
| Human | |
|---|---|
| Location: | 9q34.3 |
| Sequence: | 9; NC_000009.12 (137139092..137168759) |
Subcellular Localizations
Cell membrane; Multi-pass membrane protein. Cell junction, synapse, postsynaptic cell membrane. Cell junction, synapse, postsynaptic density. Enriched in postsynaptic plasma membrane and postsynaptic densities.
Diseases
- Schizophrenia
- Bipolar Disorder
- Depressive Disorder
- Nervousness
- Mental Disorders
- Impairment (finding)
- Major Depressive Disorder
- Neuroblastoma
- Dysequilibrium Syndrome
- Anxiety Disorders
- Psychotic Disorders
Interacting Proteins
- Dlg3
Pathways
- Pathogenesis
- Synaptic Transmission
- Localization
- Translation
- Prepulse Inhibition
- Cell Growth
- Transport
- Brain Development
- Cognition
- Cell Death
- Gene Silencing
- Habituation
- Aging
PTMs
- Phosphorylation
- Reduction
For details, visit:
bosterbio.com/bosterbio-gene-info-cards/GRIN1
bosterbio.com/bosterbio-gene-info-cards/GRIN1
References
PMID: 8406025 by Foldes R.L., et al. Cloning and sequence analysis of cDNAs encoding human hippocampus N- methyl-D-aspartate receptor subunits: evidence for alternative RNA splicing.
PMID: 7679115 by Karp S.J., et al. Molecular cloning and chromosomal localization of the key subunit of the human N-methyl-D-aspartate receptor.
7 Publications of Boster GRIN1 Antibodies & ELISA Kits
- PubMed ID: 10.4103/1673-5374.184494, Mechanisms responsible for the effect of median nerve electrical stimulation on ...
- PubMed ID: 10.3892/mmr.2017.7539, Effect of hippocampal L‑NBP on BDNF and TrkB expression and neurological funct...
- PubMed ID: 10.1186/s12871-018-0491-y, The interplay of BDNF-TrkB with NMDA receptor in propofol-induced cognition dysf...
- PubMed ID: 10.1016/j.fitote.2013.01.012, Individual and combined effects of rhynchophylline and ketamine on proliferation...
- PubMed ID: 27482224, Mechanisms responsible for the effect of median nerve electrical stimulation on ...
- PubMed ID: 22261079, Wang Xy, Wang Hw, Fu Xh, Zhang Wq, Wu Xy, Guo Qy, Wang Xm. Eur J Paediatr Neurol...
- PubMed ID: 20884369, Shang Lh, Luo Zq, Deng Xd, Wang Mj, Huang Fr, Feng Dd, Yue Sj. Nitric Oxide. 201...
*More publications can be found for each product on its corresponding product page