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- Table of Contents
Histone H2AX Antibodies
AND H2AX ELISA kits, Histone H2AX Proteins
Many biological assays use antibodies to detect Histone H2AX, such as Western Blot (WB), ELISA, Flow Cytometry, Immunocytochemistry (IHC). These antibodies can be polyclonal or monoclonal, and react with Histone H2AX in Human, Mouse, Rat, and many other animal samples. Boster Bio use mainly mouse and rabbit to develop Histone H2AX antibodies...
Designing a Western blot for Histone H2AX? The guide has the expected band size, antibodies backed by real blot images, the controls to run alongside, and protocols taken from published papers.
Open the H2AX Western Blot GuideH2AX Infographic by Boster Bio
All H2AX Products
Product
Figures
Specificity
Applications
Price
Human, Mouse, Rat
IP, IF, IHC, ICC, WB
$370
Cat # MP00241
100 μl
Cat # MP00241
100 μl
Human, Mouse, Rat
ELISA, Flow Cytometry, IP, IHC, WB
$370
Cat # A00241-1
100 μg/vial
Cat # A00241-1
100 μg/vial
Zebrafish
IHC, WB
$470
Cat # AZQ7ZUY3
100 μg/vial
Cat # AZQ7ZUY3
100 μg/vial
Human, Mouse, Rat
IP, IF, IHC, ICC, WB
$370
Cat # M00241-1
100 μl
Cat # M00241-1
100 μl
Human, Mouse, Rat
ELISA, IP, IF, IHC, WB
$146
Cat # M00241-3
20μL, 40μL, 100μL, 200μL
Cat # M00241-3
20μL, 40μL, 100μL, 200μL
Human, Mouse, Rat
ELISA
$480
Cat # EKC1274
1 kit, containing one 96-well plate and all necessary reagents
Cat # EKC1274
1 kit, containing one 96-well plate and all necessary reagents
Human, Mouse, Rat
ELISA
$540
Cat # EKC2429
1 kit, containing two 96-well plates and all necessary reagents
Cat # EKC2429
1 kit, containing two 96-well plates and all necessary reagents
Human, Mouse
ELISA
$540
Cat # EKC2552
1 kit, containing two 96-well plates and all necessary reagents
Cat # EKC2552
1 kit, containing two 96-well plates and all necessary reagents
Human
$628
Cat # LS003014
20 µg, 100 µg
Cat # LS003014
20 µg, 100 µg
Human, Monkey, Mouse, Rat
ELISA, Flow Cytometry, IF, IHC, ICC, WB
$370
Cat # A00241-4
100 μl/vial
Cat # A00241-4
100 μl/vial
H2AX Overview
Facts about Histone H2AX.
Histone H2AX (H2AX)
Variant histone H2A which replaces conventional H2A in a subset of nucleosomes. Nucleosomes wrap and compact DNA into chromatin, limiting DNA accessibility to the cellular machineries which require DNA as a template.
Histones thereby play a central role in transcription regulation, DNA repair, DNA replication and chromosomal stability. DNA accessibility is regulated by means of a complex set of post-translational modifications of histones, also known as histone code, and nucleosome remodeling.
Gene Information
| Human | |
|---|---|
| Gene Name: | H2AX |
| Uniprot: | P16104 |
| Entrez: | 3014 |
Family
| Belongs to: |
|---|
| histone H2A family |
Alternative Names
H2A histone family, member X; H2A.X; H2a/x; H2AX histone; H2AXhistone H2A.x; YH2AX
Molecular Weight
Mass (kDA):
15.145 kDA
Genomic Context
| Human | |
|---|---|
| Location: | 11q23.3 |
| Sequence: | 11; NC_000011.10 (119093874..119095465, complement) |
Subcellular Localizations
Nucleus. Chromosome.
Diseases
- Malignant Neoplasms
- Neoplasms
- Ataxia Telangiectasia
- Ataxia
- Telangiectasis
- Carcinoma
- Genomic Instability
- Malignant Neoplasm Of Breast
- Mammary Neoplasms
- Cell Transformation, Neoplastic
- Lung Neoplasms
- Cytogenetic Abnormality
Interacting Proteins
- Aifm1
- BRCA1
- HIST1H2BD
- HIST1H4A
- HIST3H3
- LMNA
- MAPK8
- MDC1
- MRE11
- NBN
Pathways
- Cell Cycle
- Dna Repair
- Cell Death
- Dna Replication
- Cell Cycle Arrest
- Senescence
- S Phase
- Mitosis
- Localization
- Double-strand Break Repair
- Induction Of Apoptosis
- Cell Killing
- Cell Proliferation
PTMs
- Phosphorylation
- Cleavage
- Dephosphorylation
- Acetylation
- Methylation
- Ubiquitination
- Reduction
- Deamination
Research Areas
- Checkpoint signaling
- DNA Double Strand Break Repair
- DNA Repair
- Mitotic Regulators
- Phospho-Specific
For details, visit:
bosterbio.com/bosterbio-gene-info-cards/H2AX
bosterbio.com/bosterbio-gene-info-cards/H2AX
References
PMID: 2587254 by Mannironi C., et al. H2A.X. a histone isoprotein with a conserved C-terminal sequence, is encoded by a novel mRNA with both DNA replication type and polyA 3' processing signals.
PMID: 9488723 by Rogakou E.P., et al. DNA double-stranded breaks induce histone H2AX phosphorylation on serine 139.