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- Table of Contents
8 Citations 16 Q&As
7 Citations 17 Q&As
5 Citations 5 Q&As
6 Citations 5 Q&As
5 Citations 4 Q&As
Facts about Endoplasmic reticulum chaperone BiP.
In the unstressed endoplasmic reticulum, recruited by DNAJB9/ERdj4 to the luminal area of ERN1/IRE1, leading to disrupt the dimerization of ERN1/IRE1, thereby inactivating ERN1/IRE1 (By similarity). Accumulation of misfolded protein in the endoplasmic reticulum causes release of HSPA5/BiP from ERN1/IRE1, allowing homodimerization and subsequent activation of ERN1/IRE1 (By similarity).
Human | |
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Gene Name: | HSPA5 |
Uniprot: | P11021 |
Entrez: | 3309 |
Belongs to: |
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heat shock protein 70 family |
78 kDa glucose-regulated protein; BIP; Endoplasmic reticulum lumenal Ca(2+)-binding protein grp78; FLJ26106; GRP78; GRP-78; GRP78BIP; Heat shock 70 kDa protein 5; heat shock 70kD protein 5 (glucose-regulated protein, 78kD); heat shock 70kDa protein 5 (glucose-regulated protein, 78kDa); HSP70-5; HSPA5; Immunoglobulin heavy chain-binding protein; MIF2
Mass (kDA):
72.333 kDA
Human | |
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Location: | 9q33.3 |
Sequence: | 9; NC_000009.12 (125234853..125241343, complement) |
Endoplasmic reticulum lumen. Melanosome. Cytoplasm. Identified by mass spectrometry in melanosome fractions from stage I to stage IV.
PMID: 2840249 by Ting J., et al. Human gene encoding the 78,000-dalton glucose-regulated protein and its pseudogene: structure, conservation, and regulation.
PMID: 1480470 by Chao C.C.K., et al. A direct-repeat sequence of the human BiP gene is required for A23187-mediated inducibility and an inducible nuclear factor binding.
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