Cation-independent mannose-6-phosphate receptor (IGF2R)

Transfer of phosphorylated lysosomal enzymes from the Golgi complex and the cell surface to lysosomes. Lysosomal enzymes bearing phosphomannosyl residues bind specifically to mannose-6- phosphate receptors in the Golgi apparatus and the resulting receptor-ligand complex is transported to an acidic prelyosomal compartment where the low pH mediates the dissociation of the complex.

This receptor also binds IGF2. Acts as a positive regulator of T-cell coactivation, by binding DPP4.