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- Table of Contents
IGF2R Antibodies
AND IGF2R ELISA kits, IGF2R Proteins
Many biological assays use antibodies to detect IGF2R, such as Western Blot (WB), ELISA, Flow Cytometry, Immunocytochemistry (IHC). These antibodies can be polyclonal or monoclonal, and react with IGF2R in Human, Mouse, Rat, and many other animal samples. Boster Bio use mainly mouse and rabbit to develop IGF2R antibodies...
Designing a Western blot for IGF2R? The guide has the expected band size, antibodies backed by real blot images, the controls to run alongside, and protocols taken from published papers.
Open the IGF2R Western Blot GuideIGF2R Infographic by Boster Bio
All IGF2R Products
Product
Figures
Specificity
Applications
Price
Human
Flow Cytometry, IF, IHC, ICC, WB
$370
Cat # M00951-1
100 μg/vial
Cat # M00951-1
100 μg/vial
Human IGF2R/IGF-II R ELISA Kit PicoKine®
2 Citations
Human
ELISA
$499
Cat # EK1326
96 wells/kit, with removable strips.
Cat # EK1326
96 wells/kit, with removable strips.
Human, Mouse, Rat
ELISA, Flow Cytometry, IF, IHC, ICC, WB
$370
Cat # A00951
100 μg/vial
Cat # A00951
100 μg/vial
Mouse, Rat
IHC, WB
$370
Cat # A00951-1
100 μg/vial
Cat # A00951-1
100 μg/vial
Human, Mouse, Rat
Flow Cytometry, WB
$370
Cat # PA2182
100 μg/vial
Cat # PA2182
100 μg/vial
Human, Mouse, Rat
Flow Cytometry, IP, IF, IHC, ICC, WB
$370
Cat # M00951
100 μl
Cat # M00951
100 μl
Human, Monkey, Mouse
ELISA, IF, IHC, WB
$380
Cat # A00951S2409
100ul
Cat # A00951S2409
100ul
IGF2R Overview
Facts about Cation-independent mannose-6-phosphate receptor.
Cation-independent mannose-6-phosphate receptor (IGF2R)
Transfer of phosphorylated lysosomal enzymes from the Golgi complex and the cell surface to lysosomes. Lysosomal enzymes bearing phosphomannosyl residues bind specifically to mannose-6- phosphate receptors in the Golgi apparatus and the resulting receptor-ligand complex is transported to an acidic prelyosomal compartment where the low pH mediates the dissociation of the complex.
This receptor also binds IGF2. Acts as a positive regulator of T-cell coactivation, by binding DPP4.
Gene Information
| Human | |
|---|---|
| Gene Name: | IGF2R |
| Uniprot: | P11717 |
| Entrez: | 3482 |
Family
| Belongs to: |
|---|
| MRL1/IGF2R family |
Alternative Names
300 kDa mannose 6-phosphate receptor; cation-independent mannose-6 phosphate receptor; cation-independent mannose-6-phosphate receptor; CD222 antigen; CD222; CI Man-6-P receptor; CIMPR; CI-MPR; IGF2R; IGF-II R; IGF-II receptor; IGFIIR; IGF-IIR; insulin-like growth factor 2 receptorM6P/IGF2R; Insulin-like growth factor II receptor; M6P/IGF2 receptor; M6PR; M6P-R; MPR 300; MPR1; MPRI; MPRIM6PR
Molecular Weight
Mass (kDA):
274.375 kDA
Genomic Context
| Human | |
|---|---|
| Location: | 6q25.3 |
| Sequence: | 6; NC_000006.12 (159969082..160111504) |
Subcellular Localizations
Lysosome membrane; Single-pass type I membrane protein. Colocalized with DPP4 in internalized cytoplasmic vesicles adjacent to the cell surface.
Diseases
- Neoplasms
- Malignant Neoplasms
- Carcinoma
- Liver Carcinoma
- Carcinogenesis
- Liver Neoplasms
- Mammary Neoplasms
- Malignant Neoplasm Of Breast
- Malignant Paraganglionic Neoplasm
- Diabetes Mellitus
- Benign Mixed Epithelial And Stromal Tumor Of Kidney
- Hepatocarcinogenesis
- Cell Transformation, Neoplastic
Interacting Proteins
- GGA1
- GGA3
- IGF2
- PACS1
Pathways
- Methylation
- Dna Methylation
- Fertilization
- Cell Growth
- Embryo Development
- Cell Proliferation
- Oogenesis
- Oocyte Growth
- Cell Cycle
- Pathogenesis
- Transport
- Secretion
- Metaphase
PTMs
- Methylation
- Phosphorylation
- Acetylation
- Demethylation
Research Areas
- Cancer
- Golgi Apparatus Markers
- Immunology
- Innate Immunity
For details, visit:
bosterbio.com/bosterbio-gene-info-cards/IGF2R
bosterbio.com/bosterbio-gene-info-cards/IGF2R
References
PMID: 2957598 by Morgan D.O., et al. Insulin-like growth factor II receptor as a multifunctional binding protein.
PMID: 2963003 by Oshima A., et al. The human cation-independent mannose 6-phosphate receptor. Cloning and sequence of the full-length cDNA and expression of functional receptor in COS cells.
5 Publications of Boster IGF2R Antibodies & ELISA Kits
- PubMed ID: 10.1080/14767058.2017.1319921, Serum levels and ApaI polymorphism of insulin-like growth factor 2 on intrauteri...
- PubMed ID: -, Yang,S.,Zhao,N.,Sun,B.,Yang,Y.,Hu,Y. and Zhao,R.(2020), Grandmaternal betaine su...
- PubMed ID: 22441995, Insulin-like growth factor I receptor involvement in proliferation of NOR-P1 cel...
- PubMed ID: 28460554, Serum levels and ApaI polymorphism of insulin-like growth factor 2 on intrauteri...
- PubMed ID: 22720981, Insulin-like growth factors in endometrioid adenocarcinoma: Correlation with cli...
*More publications can be found for each product on its corresponding product page