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- Table of Contents
3 Citations 8 Q&As
1 Citations 7 Q&As
2 Citations
Facts about Cation-independent mannose-6-phosphate receptor.
This receptor also binds IGF2. Acts as a positive regulator of T-cell coactivation, by binding DPP4.
Human | |
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Gene Name: | IGF2R |
Uniprot: | P11717 |
Entrez: | 3482 |
Belongs to: |
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MRL1/IGF2R family |
300 kDa mannose 6-phosphate receptor; cation-independent mannose-6 phosphate receptor; cation-independent mannose-6-phosphate receptor; CD222 antigen; CD222; CI Man-6-P receptor; CIMPR; CI-MPR; IGF2R; IGF-II R; IGF-II receptor; IGFIIR; IGF-IIR; insulin-like growth factor 2 receptorM6P/IGF2R; Insulin-like growth factor II receptor; M6P/IGF2 receptor; M6PR; M6P-R; MPR 300; MPR1; MPRI; MPRIM6PR
Mass (kDA):
274.375 kDA
Human | |
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Location: | 6q25.3 |
Sequence: | 6; NC_000006.12 (159969082..160111504) |
Lysosome membrane; Single-pass type I membrane protein. Colocalized with DPP4 in internalized cytoplasmic vesicles adjacent to the cell surface.
The IGF2R Marker is a diagnostic marker and/or a predictive one for advanced liver fibrosis. The IGF2R protein has been validated by the WB and expressed in biological samples. As as of January 1, 2012 no other antibody had demonstrated an equivalent level of specificity and affinity. Boster's antibodies provide many advantages that include high specificity and high affinity.
The IGF2R receptor, also known as the IGF2R is a significant biomarker for advanced liver fibrosis. If the IGF2R gene is detected at an elevated amount, it could be a sign of advanced liver disease. It could also be a sign of non-advanced liver fibrosis. In addition IGF2R indicators could serve as biomarkers for diagnosis.
The different between the tests and control samples determines markers expression levels. Higher levels of expression means that the levels of the marker were greater than the standard error of both test and control samples. A higher expression means that the expression level of a marker is more than three times or twice higher than a normal level. In other terms, higher levels of expression suggest a higher degree of liver fibrosis.
Patients must have a predetermined threshold in order to use the marker for prognostication and diagnosis. This threshold value can be an absolute level or a relative amount. The reference level may also be a reference to the presence of the biomarker, or to any range of levels. It could also refer to the median or upper limits of normal.
The two different kinds of nucleic acid are present in the liver. Nucleic acid includes DNA and RNA. DNA is a type deoxyribonucleic acids. The adenine residue in the first nucleic acid area forms specific hydrogen bonds with the adenine molecule in the second nucleic acid region.
IGF2R is, in addition to these biomarkers is important for assessing the severity and extent of hepatic impairment. The current study contains several IGF2R assays, including a new test that is based on genes and correlates IGF2R with various parameters of liver fibrosis.
Additionally the Boster Bio IGF2R test can also reveal the presence of NASH and NAFLD. In addition, the test may help in the development of treatments and better management of these diseases. However, more research is needed. A test for advanced liverfibrosis is vital to ensure the success of treatment. So, what are the Boster Bio IGF2R markers?
Insulin-like growth factors binding proteins (IGFBPs) IGFBPs, a group of proteins with the same domain structure, are related proteins. Figure 1 shows the IGFBP-5 domain organization. The protein can release a signal peptide out of the cytoplasm into ECM. Based on its functions, IGFBP-5 may affect cell movement and survival. This study was conducted to determine if mutations in the PI3K/AKT pathway impacted IGFBP-5 expression in breast cancer.
IGFBPs are vital to normal cell physiology, as well as the development of cancer. The diverse functions of IGFBPs result from the fact that they are chosen from a group of proteins chosen from a range of animal and human tissues. IGFBP-5 one of these proteins could be a potential therapeutic target for breast cancer. Further, the interaction between these proteins could provide new therapeutic approaches for the treatment of cancer.
IGFBP-5 interacts with a variety of proteins. These proteins include osteopontin and fibronectin. The interactions between IGFBP-5 and these proteins are believed to be catalyzed by the IGFBP-5's basic carboxyl-terminal domain. These proteins could be IGF-dependent or even independent.
It has been established that IGFBP-5 blocks MMPs' actions by affecting the plasmin receptor and other MMPs. The interaction between IGFBP-5 and PRL may affect both MMPs and the plasmin gene in a mutually beneficial manner. Both compounds are involved in the apoptotic pathway. Further research is required to establish the precise roles of these proteins in mammary glands.
Both proteins can play a role within cell migration and attachment to mammary epithelium. IGFBP-5 regulates growth of cells through binding to IGFs. PRL is another group of receptors that regulates the development of mammary epithelium. It also plays an significant role in the migration of breast cancer cells. These molecules are chosen from a group that includes IGFBP-5 and PRL.
The book has chapters written by Jean Djiane, Xiao Ou Shu. This book is a comprehensive review on the current knowledge about the role PRL plays in and breast cancer. The authors suggest that gene therapy that targets IGFBP-5 could be worth a look. The authors plan to publish another book on the role this protein plays in breast cancer research.
IGF2R is a receptor for growth hormones that can be found in mammals. The biological samples of rat and human adipose tissues are often used to test. The markers, which are expressed in biological samples are able to identify the presence of this hormone, a precursor to insulin. As with other growth hormone receptors, there are many ways to determine the expression levels of markers. Plasma is the most commonly used method for measuring markers' expression, while serum is the preferred method.
Boster Bio is a leading antibody manufacturer, specializing in specific and sensitive antibodies. Boster's research-grade antibodies are validated using WB and IHC against a panel of 250 tissue samples. Boster also tests their antibodies quantitatively, testing them against known amounts of recombinant proteins , as well as untransfected cell lines. Here are the best uses for the IGF2R marker.
The Picokine(tm) platform is an innovative platform for immunoassay with increased sensitivity, up to the picogram level. The Picokine(tm) ELISA kits have been tested on a wide range of samples that include human adipose tissues and prostate cancer. You can request detailed validation images and procedures. The Picoband kit is built on proprietary trade secrets and is optimized to speed up time and guarantee high sensitivity. Technical support is provided by Sanbio, a BeNeLux distributor.
Boster Bio antibodies to the IGF2R are highly specific. They react with many animal samples. These antibodies are derived mainly from rabbit and mouse. Since these antibodies are specific they can be utilized in a variety of ways. They have been validated on WB and immunohistochemistry. If you can, always employ a negative control to identify false positives.
PMID: 2957598 by Morgan D.O., et al. Insulin-like growth factor II receptor as a multifunctional binding protein.
PMID: 2963003 by Oshima A., et al. The human cation-independent mannose 6-phosphate receptor. Cloning and sequence of the full-length cDNA and expression of functional receptor in COS cells.
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